GB1455997A - M-dioxane-5-methylamine analgesics - Google Patents
M-dioxane-5-methylamine analgesicsInfo
- Publication number
- GB1455997A GB1455997A GB5711373A GB5711373A GB1455997A GB 1455997 A GB1455997 A GB 1455997A GB 5711373 A GB5711373 A GB 5711373A GB 5711373 A GB5711373 A GB 5711373A GB 1455997 A GB1455997 A GB 1455997A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- image
- analgesics
- methylamine
- dioxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Abstract
The m-dioxanes correspond to the formula I <IMAGE> the meanings of the symbols being given in Patent Claim 1. The compounds, as well as those which have been partially demethylated at the amine nitrogen, exhibit an excellent analgesic action without producing addiction in the treated patient. The compounds are prepared by reacting a ketone of the formula II <IMAGE> with an amine of the formula <IMAGE> and reducing the resulting enamine catalytically in the presence of hydrogen to give a compound of the formula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31322172A | 1972-12-08 | 1972-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1455997A true GB1455997A (en) | 1976-11-17 |
Family
ID=23214841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5711373A Expired GB1455997A (en) | 1972-12-08 | 1973-12-10 | M-dioxane-5-methylamine analgesics |
| GB2900376A Expired GB1455998A (en) | 1972-12-08 | 1973-12-10 | 2-alpha-substituted-amino-benzyl-1,3-propane-diols |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2900376A Expired GB1455998A (en) | 1972-12-08 | 1973-12-10 | 2-alpha-substituted-amino-benzyl-1,3-propane-diols |
Country Status (27)
| Country | Link |
|---|---|
| JP (2) | JPS5734835B2 (en) |
| AR (3) | AR206306A1 (en) |
| AT (2) | AT332396B (en) |
| BE (1) | BE808340A (en) |
| BG (4) | BG21223A3 (en) |
| CA (2) | CA1014560A (en) |
| CH (4) | CH605903A5 (en) |
| CS (3) | CS193480B2 (en) |
| CY (1) | CY1017A (en) |
| DD (3) | DD115653A5 (en) |
| DE (1) | DE2361340C2 (en) |
| DK (1) | DK134717B (en) |
| ES (4) | ES421291A1 (en) |
| FR (1) | FR2209578B1 (en) |
| GB (2) | GB1455997A (en) |
| HK (1) | HK60479A (en) |
| HU (2) | HU168620B (en) |
| IE (1) | IE40226B1 (en) |
| IL (1) | IL43773A (en) |
| KE (1) | KE2976A (en) |
| MY (1) | MY8000064A (en) |
| NL (1) | NL7316839A (en) |
| PH (2) | PH15197A (en) |
| SE (3) | SE403377B (en) |
| SU (4) | SU578001A3 (en) |
| YU (3) | YU35447B (en) |
| ZA (1) | ZA739207B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9376409B2 (en) * | 2012-05-09 | 2016-06-28 | Boehringer Ingelheim International Gmbh | Methods for making oxetan-3-ylmethanamines |
| LV14983B (en) * | 2013-10-15 | 2015-06-20 | Olainfarm, A/S | Method for producing intermediates of phenibut |
-
1973
- 1973-01-01 AR AR251422A patent/AR206306A1/en active
- 1973-12-04 IE IE2190/73A patent/IE40226B1/en unknown
- 1973-12-04 ZA ZA00739207A patent/ZA739207B/en unknown
- 1973-12-06 PH PH15299A patent/PH15197A/en unknown
- 1973-12-06 CA CA187,516A patent/CA1014560A/en not_active Expired
- 1973-12-07 DK DK663373AA patent/DK134717B/en not_active IP Right Cessation
- 1973-12-07 FR FR7343848A patent/FR2209578B1/fr not_active Expired
- 1973-12-07 CA CA187,636A patent/CA1024150A/en not_active Expired
- 1973-12-07 ES ES73421291A patent/ES421291A1/en not_active Expired
- 1973-12-07 NL NL7316839A patent/NL7316839A/xx not_active Application Discontinuation
- 1973-12-07 ES ES73421290A patent/ES421290A1/en not_active Expired
- 1973-12-07 HU HUEI510A patent/HU168620B/hu unknown
- 1973-12-07 IL IL43773A patent/IL43773A/en unknown
- 1973-12-07 SU SU7301978316A patent/SU578001A3/en active
- 1973-12-07 AT AT1026173A patent/AT332396B/en not_active IP Right Cessation
- 1973-12-07 CH CH1720973A patent/CH605903A5/xx not_active IP Right Cessation
- 1973-12-07 AT AT1026073A patent/AT330773B/en not_active IP Right Cessation
- 1973-12-07 CH CH17977A patent/CH614439A5/en not_active IP Right Cessation
- 1973-12-07 BE BE1005568A patent/BE808340A/en not_active IP Right Cessation
- 1973-12-07 SE SE7316586A patent/SE403377B/en unknown
- 1973-12-07 SU SU731977567A patent/SU587861A3/en active
- 1973-12-07 CH CH1720873A patent/CH619219A5/en not_active IP Right Cessation
- 1973-12-07 YU YU3184/73A patent/YU35447B/en unknown
- 1973-12-07 AR AR251423A patent/AR212416A1/en active
- 1973-12-07 YU YU3185/73A patent/YU36171B/en unknown
- 1973-12-07 HU HUEI511A patent/HU168763B/hu unknown
- 1973-12-08 BG BG25193A patent/BG21223A3/xx unknown
- 1973-12-08 DE DE2361340A patent/DE2361340C2/en not_active Expired
- 1973-12-08 JP JP14024573A patent/JPS5734835B2/ja not_active Expired
- 1973-12-08 BG BG28633A patent/BG21409A3/xx unknown
- 1973-12-08 BG BG7328632A patent/BG26205A4/xx unknown
- 1973-12-08 BG BG27548A patent/BG22386A3/xx unknown
- 1973-12-08 JP JP48140246A patent/JPS5742633B2/ja not_active Expired
- 1973-12-10 CS CS738528A patent/CS193480B2/en unknown
- 1973-12-10 GB GB5711373A patent/GB1455997A/en not_active Expired
- 1973-12-10 CY CY1017A patent/CY1017A/en unknown
- 1973-12-10 CS CS765892A patent/CS222209B2/en unknown
- 1973-12-10 DD DD179119*A patent/DD115653A5/xx unknown
- 1973-12-10 CS CS738529A patent/CS222208B2/en unknown
- 1973-12-10 GB GB2900376A patent/GB1455998A/en not_active Expired
- 1973-12-10 DD DD175232A patent/DD110864A5/xx unknown
- 1973-12-10 DD DD175231A patent/DD109625A5/xx unknown
-
1975
- 1975-01-27 SU SU752100370A patent/SU648081A3/en active
- 1975-02-19 SU SU752106121A patent/SU663305A3/en active
- 1975-05-14 AR AR258799A patent/AR212012A1/en active
-
1976
- 1976-01-28 ES ES444716A patent/ES444716A1/en not_active Expired
- 1976-02-04 ES ES444911A patent/ES444911A1/en not_active Expired
- 1976-04-30 PH PH18384A patent/PH14923A/en unknown
-
1977
- 1977-02-17 SE SE7701796A patent/SE428378B/en unknown
- 1977-02-17 SE SE7701795A patent/SE417196B/en unknown
-
1979
- 1979-07-03 KE KE2976A patent/KE2976A/en unknown
- 1979-08-23 HK HK604/79A patent/HK60479A/en unknown
- 1979-09-06 CH CH805879A patent/CH630914A5/en not_active IP Right Cessation
-
1980
- 1980-04-22 YU YU1093/80A patent/YU36020B/en unknown
- 1980-12-30 MY MY64/80A patent/MY8000064A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |