IE40226L - 5-AMINOMETHYL-m-DIOXANES. - Google Patents
5-AMINOMETHYL-m-DIOXANES.Info
- Publication number
- IE40226L IE40226L IE732190A IE219073A IE40226L IE 40226 L IE40226 L IE 40226L IE 732190 A IE732190 A IE 732190A IE 219073 A IE219073 A IE 219073A IE 40226 L IE40226 L IE 40226L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- image
- dioxanes
- compounds
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The m-dioxanes correspond to the formula I <IMAGE> the meanings of the symbols being given in Patent Claim 1. The compounds, as well as those which have been partially demethylated at the amine nitrogen, exhibit an excellent analgesic action without producing addiction in the treated patient. The compounds are prepared by reacting a ketone of the formula II <IMAGE> with an amine of the formula <IMAGE> and reducing the resulting enamine catalytically in the presence of hydrogen to give a compound of the formula I.
[GB1455997A]
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE2342/77A IE40227B1 (en) | 1972-12-08 | 1973-12-04 | 2-(-(substituted) amino-benzyl)-1,3-propanediols |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31322172A | 1972-12-08 | 1972-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE40226L true IE40226L (en) | 1974-06-08 |
IE40226B1 IE40226B1 (en) | 1979-04-11 |
Family
ID=23214841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE2190/73A IE40226B1 (en) | 1972-12-08 | 1973-12-04 | M-dioxane-5-methylamine analgesics |
Country Status (27)
Country | Link |
---|---|
JP (2) | JPS5734835B2 (en) |
AR (3) | AR206306A1 (en) |
AT (2) | AT330773B (en) |
BE (1) | BE808340A (en) |
BG (4) | BG22386A3 (en) |
CA (2) | CA1014560A (en) |
CH (4) | CH619219A5 (en) |
CS (3) | CS222209B2 (en) |
CY (1) | CY1017A (en) |
DD (3) | DD110864A5 (en) |
DE (1) | DE2361340C2 (en) |
DK (1) | DK134717B (en) |
ES (4) | ES421291A1 (en) |
FR (1) | FR2209578B1 (en) |
GB (2) | GB1455997A (en) |
HK (1) | HK60479A (en) |
HU (2) | HU168620B (en) |
IE (1) | IE40226B1 (en) |
IL (1) | IL43773A (en) |
KE (1) | KE2976A (en) |
MY (1) | MY8000064A (en) |
NL (1) | NL7316839A (en) |
PH (2) | PH15197A (en) |
SE (3) | SE403377B (en) |
SU (4) | SU587861A3 (en) |
YU (3) | YU35447B (en) |
ZA (1) | ZA739207B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013169531A1 (en) * | 2012-05-09 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Methods for making oxetan-3-ylmethanamines |
LV14983B (en) * | 2013-10-15 | 2015-06-20 | Olainfarm, A/S | Method for producing intermediates of phenibut |
-
1973
- 1973-01-01 AR AR251422A patent/AR206306A1/en active
- 1973-12-04 IE IE2190/73A patent/IE40226B1/en unknown
- 1973-12-04 ZA ZA00739207A patent/ZA739207B/en unknown
- 1973-12-06 CA CA187,516A patent/CA1014560A/en not_active Expired
- 1973-12-06 PH PH15299A patent/PH15197A/en unknown
- 1973-12-07 YU YU3184/73A patent/YU35447B/en unknown
- 1973-12-07 AT AT1026073A patent/AT330773B/en not_active IP Right Cessation
- 1973-12-07 HU HUEI510A patent/HU168620B/hu unknown
- 1973-12-07 BE BE1005568A patent/BE808340A/en not_active IP Right Cessation
- 1973-12-07 SU SU731977567A patent/SU587861A3/en active
- 1973-12-07 FR FR7343848A patent/FR2209578B1/fr not_active Expired
- 1973-12-07 ES ES73421291A patent/ES421291A1/en not_active Expired
- 1973-12-07 AT AT1026173A patent/AT332396B/en not_active IP Right Cessation
- 1973-12-07 CH CH1720873A patent/CH619219A5/en not_active IP Right Cessation
- 1973-12-07 HU HUEI511A patent/HU168763B/hu unknown
- 1973-12-07 CH CH17977A patent/CH614439A5/en not_active IP Right Cessation
- 1973-12-07 CA CA187,636A patent/CA1024150A/en not_active Expired
- 1973-12-07 CH CH1720973A patent/CH605903A5/xx not_active IP Right Cessation
- 1973-12-07 NL NL7316839A patent/NL7316839A/xx not_active Application Discontinuation
- 1973-12-07 DK DK663373AA patent/DK134717B/en not_active IP Right Cessation
- 1973-12-07 IL IL43773A patent/IL43773A/en unknown
- 1973-12-07 ES ES73421290A patent/ES421290A1/en not_active Expired
- 1973-12-07 YU YU3185/73A patent/YU36171B/en unknown
- 1973-12-07 SE SE7316586A patent/SE403377B/en unknown
- 1973-12-07 AR AR251423A patent/AR212416A1/en active
- 1973-12-07 SU SU7301978316A patent/SU578001A3/en active
- 1973-12-08 BG BG27548A patent/BG22386A3/xx unknown
- 1973-12-08 BG BG25193A patent/BG21223A3/xx unknown
- 1973-12-08 JP JP14024573A patent/JPS5734835B2/ja not_active Expired
- 1973-12-08 BG BG28633A patent/BG21409A3/xx unknown
- 1973-12-08 DE DE2361340A patent/DE2361340C2/en not_active Expired
- 1973-12-08 BG BG7328632A patent/BG26205A4/xx unknown
- 1973-12-08 JP JP48140246A patent/JPS5742633B2/ja not_active Expired
- 1973-12-10 GB GB5711373A patent/GB1455997A/en not_active Expired
- 1973-12-10 GB GB2900376A patent/GB1455998A/en not_active Expired
- 1973-12-10 DD DD175232A patent/DD110864A5/xx unknown
- 1973-12-10 CS CS765892A patent/CS222209B2/en unknown
- 1973-12-10 DD DD179119*A patent/DD115653A5/xx unknown
- 1973-12-10 CS CS738528A patent/CS193480B2/en unknown
- 1973-12-10 DD DD175231A patent/DD109625A5/xx unknown
- 1973-12-10 CY CY1017A patent/CY1017A/en unknown
- 1973-12-10 CS CS738529A patent/CS222208B2/en unknown
-
1975
- 1975-01-27 SU SU752100370A patent/SU648081A3/en active
- 1975-02-19 SU SU752106121A patent/SU663305A3/en active
- 1975-05-14 AR AR258799A patent/AR212012A1/en active
-
1976
- 1976-01-28 ES ES444716A patent/ES444716A1/en not_active Expired
- 1976-02-04 ES ES444911A patent/ES444911A1/en not_active Expired
- 1976-04-30 PH PH18384A patent/PH14923A/en unknown
-
1977
- 1977-02-17 SE SE7701796A patent/SE428378B/en unknown
- 1977-02-17 SE SE7701795A patent/SE417196B/en unknown
-
1979
- 1979-07-03 KE KE2976A patent/KE2976A/en unknown
- 1979-08-23 HK HK604/79A patent/HK60479A/en unknown
- 1979-09-06 CH CH805879A patent/CH630914A5/en not_active IP Right Cessation
-
1980
- 1980-04-22 YU YU1093/80A patent/YU36020B/en unknown
- 1980-12-30 MY MY64/80A patent/MY8000064A/en unknown
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