ES421291A1 - M-dioxane-5-methylamine analgesics - Google Patents

M-dioxane-5-methylamine analgesics

Info

Publication number
ES421291A1
ES421291A1 ES73421291A ES421291A ES421291A1 ES 421291 A1 ES421291 A1 ES 421291A1 ES 73421291 A ES73421291 A ES 73421291A ES 421291 A ES421291 A ES 421291A ES 421291 A1 ES421291 A1 ES 421291A1
Authority
ES
Spain
Prior art keywords
formula
image
analgesics
methylamine
dioxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES73421291A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES421291A1 publication Critical patent/ES421291A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Abstract

The m-dioxanes correspond to the formula I < IMAGE > the meanings of the symbols being given in Patent Claim 1. The compounds, as well as those which have been partially demethylated at the amine nitrogen, exhibit an excellent analgesic action without producing addiction in the treated patient. The compounds are prepared by reacting a ketone of the formula II < IMAGE > with an amine of the formula < IMAGE > and reducing the resulting enamine catalytically in the presence of hydrogen to give a compound of the formula I.
ES73421291A 1972-12-08 1973-12-07 M-dioxane-5-methylamine analgesics Expired ES421291A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31322172A 1972-12-08 1972-12-08

Publications (1)

Publication Number Publication Date
ES421291A1 true ES421291A1 (en) 1976-07-01

Family

ID=23214841

Family Applications (4)

Application Number Title Priority Date Filing Date
ES73421291A Expired ES421291A1 (en) 1972-12-08 1973-12-07 M-dioxane-5-methylamine analgesics
ES73421290A Expired ES421290A1 (en) 1972-12-08 1973-12-07 M-dioxane-5-methylamine analgesics
ES444716A Expired ES444716A1 (en) 1972-12-08 1976-01-28 M-dioxane-5-methylamine analgesics
ES444911A Expired ES444911A1 (en) 1972-12-08 1976-02-04 M-dioxane-5-methylamine analgesics

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES73421290A Expired ES421290A1 (en) 1972-12-08 1973-12-07 M-dioxane-5-methylamine analgesics
ES444716A Expired ES444716A1 (en) 1972-12-08 1976-01-28 M-dioxane-5-methylamine analgesics
ES444911A Expired ES444911A1 (en) 1972-12-08 1976-02-04 M-dioxane-5-methylamine analgesics

Country Status (27)

Country Link
JP (2) JPS5734835B2 (en)
AR (3) AR206306A1 (en)
AT (2) AT332396B (en)
BE (1) BE808340A (en)
BG (4) BG21223A3 (en)
CA (2) CA1014560A (en)
CH (4) CH605903A5 (en)
CS (3) CS193480B2 (en)
CY (1) CY1017A (en)
DD (3) DD115653A5 (en)
DE (1) DE2361340C2 (en)
DK (1) DK134717B (en)
ES (4) ES421291A1 (en)
FR (1) FR2209578B1 (en)
GB (2) GB1455997A (en)
HK (1) HK60479A (en)
HU (2) HU168620B (en)
IE (1) IE40226B1 (en)
IL (1) IL43773A (en)
KE (1) KE2976A (en)
MY (1) MY8000064A (en)
NL (1) NL7316839A (en)
PH (2) PH15197A (en)
SE (3) SE403377B (en)
SU (4) SU578001A3 (en)
YU (3) YU35447B (en)
ZA (1) ZA739207B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9376409B2 (en) * 2012-05-09 2016-06-28 Boehringer Ingelheim International Gmbh Methods for making oxetan-3-ylmethanamines
LV14983B (en) * 2013-10-15 2015-06-20 Olainfarm, A/S Method for producing intermediates of phenibut

Also Published As

Publication number Publication date
BE808340A (en) 1974-06-07
SU663305A3 (en) 1979-05-15
BG21409A3 (en) 1976-05-20
CA1024150A (en) 1978-01-10
YU36171B (en) 1982-02-25
CS222209B2 (en) 1983-05-27
DK134717B (en) 1977-01-03
DE2361340A1 (en) 1974-06-12
BG26205A4 (en) 1979-02-15
JPS4987680A (en) 1974-08-22
SE428378B (en) 1983-06-27
DD110864A5 (en) 1975-01-12
ATA1026073A (en) 1975-10-15
BG22386A3 (en) 1977-02-20
SE417196B (en) 1981-03-02
SE7701795L (en) 1977-02-17
CS193480B2 (en) 1979-10-31
IL43773A0 (en) 1974-03-14
NL7316839A (en) 1974-06-11
JPS4987681A (en) 1974-08-22
YU318573A (en) 1981-06-30
HU168620B (en) 1976-06-28
YU318473A (en) 1980-09-25
YU35447B (en) 1981-02-28
FR2209578B1 (en) 1977-09-02
FR2209578A1 (en) 1974-07-05
HK60479A (en) 1979-08-31
DD109625A5 (en) 1974-11-12
MY8000064A (en) 1980-12-31
AT330773B (en) 1976-07-26
YU109380A (en) 1981-04-30
BG21223A3 (en) 1976-03-20
SE7701796L (en) 1977-02-17
SE403377B (en) 1978-08-14
CH614439A5 (en) 1979-11-30
AT332396B (en) 1976-09-27
SU587861A3 (en) 1978-01-05
CH605903A5 (en) 1978-10-13
ES444911A1 (en) 1977-09-01
HU168763B (en) 1976-07-28
IL43773A (en) 1979-05-31
YU36020B (en) 1981-11-13
IE40226B1 (en) 1979-04-11
KE2976A (en) 1979-07-20
CH619219A5 (en) 1980-09-15
AR206306A1 (en) 1976-07-15
CY1017A (en) 1979-11-23
JPS5734835B2 (en) 1982-07-26
ES421290A1 (en) 1976-07-01
ZA739207B (en) 1975-07-30
CA1014560A (en) 1977-07-26
ATA1026173A (en) 1976-01-15
GB1455998A (en) 1976-11-17
SU578001A3 (en) 1977-10-25
JPS5742633B2 (en) 1982-09-09
AR212416A1 (en) 1978-07-14
DE2361340C2 (en) 1983-11-24
CH630914A5 (en) 1982-07-15
AU6321773A (en) 1975-06-05
CS222208B2 (en) 1983-05-27
GB1455997A (en) 1976-11-17
AR212012A1 (en) 1978-04-28
DK134717C (en) 1977-05-31
IE40226L (en) 1974-06-08
PH15197A (en) 1982-09-17
SU648081A3 (en) 1979-02-15
ES444716A1 (en) 1977-05-16
PH14923A (en) 1982-01-29
DD115653A5 (en) 1975-10-12

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