GB1452891A - Tricyclic tetrazole derivatives their synthesis and compositions containing them - Google Patents

Tricyclic tetrazole derivatives their synthesis and compositions containing them

Info

Publication number
GB1452891A
GB1452891A GB820073*[A GB820073A GB1452891A GB 1452891 A GB1452891 A GB 1452891A GB 820073 A GB820073 A GB 820073A GB 1452891 A GB1452891 A GB 1452891A
Authority
GB
United Kingdom
Prior art keywords
compounds
radicals
formula
meaning stated
tricyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB820073*[A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB820073*[A priority Critical patent/GB1452891A/en
Priority to US05/394,423 priority patent/US3939173A/en
Priority to DE19732344814 priority patent/DE2344814A1/en
Priority to AU60038/73A priority patent/AU482864B2/en
Priority to JP48099387A priority patent/JPS5849549B2/en
Priority to IL43160A priority patent/IL43160A/en
Priority to CA180,386A priority patent/CA1020551A/en
Priority to FR7332117A priority patent/FR2197606B1/fr
Priority to CH1282573A priority patent/CH626613A5/en
Priority to NL7312282A priority patent/NL7312282A/xx
Priority to IE1589/73A priority patent/IE38234B1/en
Priority to US05/634,456 priority patent/US4039556A/en
Priority to US05/634,450 priority patent/US4012500A/en
Priority to US05/635,768 priority patent/US4094968A/en
Publication of GB1452891A publication Critical patent/GB1452891A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Polycyclic compounds which contain at least one tetrazole ring and have the formula 1 in which the radicals Z<1>, Z<2> and Z<3> have the meaning stated in Claim 1 are obtained by reacting compounds of the formula 2 in which the radicals Y<1> and Y<2> have the meaning stated in Claim 1 with hydrazoic acid or a salt thereof, or by reacting compounds of the formula 2 in which the radicals Y<1> and Y<2> have the meaning stated in Claim 10 with nitrous acid, or by reacting compounds of the formula 2 in which the radicals Y<1> and Y<2> have the meaning stated in Claim 19 with nitrous acid and reducing the nitrosation product which is formed. The compounds are converted where appropriate into their salts or, if at least one of the substituents Z<1> and Z<2> is a carboxyl group, into their esters or amides by esterification or amidation. The compounds act as inhibitors in certain allergic reactions in mammals. <IMAGE>
GB820073*[A 1972-09-06 1973-02-20 Tricyclic tetrazole derivatives their synthesis and compositions containing them Expired GB1452891A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB820073*[A GB1452891A (en) 1972-09-06 1973-02-20 Tricyclic tetrazole derivatives their synthesis and compositions containing them
US05/394,423 US3939173A (en) 1972-09-06 1973-09-05 Substituted carbonyl compounds
DE19732344814 DE2344814A1 (en) 1972-09-06 1973-09-05 NITROGEN HETEROCYCLIC COMPOUNDS
AU60038/73A AU482864B2 (en) 1973-09-05 Nitrogen heterocycles
JP48099387A JPS5849549B2 (en) 1972-09-06 1973-09-05 Method for producing novel anti-allergic tricyclic compound
IL43160A IL43160A (en) 1972-09-06 1973-09-05 2-(1h-tetrazol-5-yl)-fluorenone xanthenone and acridone derivatives their preparation and pharmaceutical compositions containing them
CA180,386A CA1020551A (en) 1972-09-06 1973-09-06 Anthraquinonyl and fluorenonyl tetrazoles
FR7332117A FR2197606B1 (en) 1972-09-06 1973-09-06
CH1282573A CH626613A5 (en) 1972-09-06 1973-09-06 Process for the preparation of polycyclic compounds containing at least one tetrazole ring
NL7312282A NL7312282A (en) 1972-09-06 1973-09-06
IE1589/73A IE38234B1 (en) 1972-09-06 1973-09-06 Tricyclic tetrazole derivatives their synthesis and composistions containing them
US05/634,456 US4039556A (en) 1972-09-06 1975-11-24 Substituted carbonyl compounds
US05/634,450 US4012500A (en) 1972-09-06 1975-11-24 Method and composition to inhibit symptoms of allergy
US05/635,768 US4094968A (en) 1972-09-06 1975-11-26 Treatment for allergy and method of composition thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB4143072 1972-09-06
GB4143172 1972-09-06
GB4143272 1972-09-06
GB820073*[A GB1452891A (en) 1972-09-06 1973-02-20 Tricyclic tetrazole derivatives their synthesis and compositions containing them
GB829273 1973-02-20

Publications (1)

Publication Number Publication Date
GB1452891A true GB1452891A (en) 1976-10-20

Family

ID=27515847

Family Applications (1)

Application Number Title Priority Date Filing Date
GB820073*[A Expired GB1452891A (en) 1972-09-06 1973-02-20 Tricyclic tetrazole derivatives their synthesis and compositions containing them

Country Status (8)

Country Link
JP (1) JPS5849549B2 (en)
CH (1) CH626613A5 (en)
DE (1) DE2344814A1 (en)
FR (1) FR2197606B1 (en)
GB (1) GB1452891A (en)
IE (1) IE38234B1 (en)
IL (1) IL43160A (en)
NL (1) NL7312282A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598155A (en) * 1981-11-18 1986-07-01 Ciba-Geigy Corporation 3(5-tetrazolyl)1,4-diaminoanthraquinones
WO2003041704A1 (en) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Preventive or remedy for pruritus

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714669A (en) * 1985-04-11 1987-12-22 Ciba-Geigy Corporation Radiation-sensitive polycondensates, their preparation, material coated therewith and the use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759292A (en) * 1969-11-27 1971-05-24 Allen & Hanburys Ltd XANTHONE DERIVATIVES, THEIR PREPARATION AND THEIR USE
GB1339010A (en) * 1970-11-27 1973-11-28 Allen & Hanburys Ltd Tetrazolyl-anthraquinone derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598155A (en) * 1981-11-18 1986-07-01 Ciba-Geigy Corporation 3(5-tetrazolyl)1,4-diaminoanthraquinones
WO2003041704A1 (en) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Preventive or remedy for pruritus

Also Published As

Publication number Publication date
FR2197606A1 (en) 1974-03-29
IL43160A0 (en) 1973-11-28
IE38234B1 (en) 1978-02-01
CH626613A5 (en) 1981-11-30
NL7312282A (en) 1974-03-08
JPS4985069A (en) 1974-08-15
IE38234L (en) 1974-03-06
AU6003873A (en) 1975-03-06
JPS5849549B2 (en) 1983-11-05
IL43160A (en) 1977-02-28
DE2344814A1 (en) 1974-03-14
FR2197606B1 (en) 1976-05-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee