ES432305A1 - Preparation of 7-acylamino cephalosporin derivatives - Google Patents
Preparation of 7-acylamino cephalosporin derivativesInfo
- Publication number
- ES432305A1 ES432305A1 ES432305A ES432305A ES432305A1 ES 432305 A1 ES432305 A1 ES 432305A1 ES 432305 A ES432305 A ES 432305A ES 432305 A ES432305 A ES 432305A ES 432305 A1 ES432305 A1 ES 432305A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- preparation
- derivative
- cephalosporin derivatives
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephem derivatives of the following formula < IMAGE > in which the substituents are defined in Claim 1, are prepared by a novel process. In this process, an appropriate 7-acylamidocephem derivative having a protected carboxyl group in the 4-position is reacted in the presence of a molecular sieve with an acylating agent donating the desired acyl radical. The original acyl group is removed from the initially resulting 7-diacylamidocephem derivative. The free acid is obtained by removal of the protective group R'', which preferably represents an easily removable ester group. The said compounds are used as antibiotics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42041873A | 1973-11-30 | 1973-11-30 | |
US50747374A | 1974-09-23 | 1974-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES432305A1 true ES432305A1 (en) | 1977-06-16 |
Family
ID=27024839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES432305A Expired ES432305A1 (en) | 1973-11-30 | 1974-11-26 | Preparation of 7-acylamino cephalosporin derivatives |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS6020393B2 (en) |
AR (1) | AR211234A1 (en) |
CA (1) | CA1041481A (en) |
CH (1) | CH618443A5 (en) |
DD (1) | DD115125A5 (en) |
DE (1) | DE2456528C2 (en) |
DK (1) | DK153154C (en) |
ES (1) | ES432305A1 (en) |
FI (1) | FI60210C (en) |
FR (1) | FR2253022B1 (en) |
GB (1) | GB1480757A (en) |
HU (1) | HU168823B (en) |
IE (1) | IE40122B1 (en) |
IT (1) | IT1043920B (en) |
NL (1) | NL187023C (en) |
NO (1) | NO147839C (en) |
SE (1) | SE432934B (en) |
YU (1) | YU36736B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56158790A (en) * | 1980-05-14 | 1981-12-07 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2127225A1 (en) * | 1970-06-12 | 1971-12-16 | Yamanouchi Pharmaceutical Co Ltd , Tokio | New process for making cephalexin |
US3843639A (en) * | 1973-02-08 | 1974-10-22 | Bristol Myers Co | Production of cephalexin via methoxymethyl ester |
-
1974
- 1974-11-13 NL NLAANVRAGE7414820,A patent/NL187023C/en not_active IP Right Cessation
- 1974-11-13 SE SE7414249A patent/SE432934B/en not_active IP Right Cessation
- 1974-11-13 DK DK589474A patent/DK153154C/en not_active IP Right Cessation
- 1974-11-14 NO NO744088A patent/NO147839C/en unknown
- 1974-11-14 FI FI3301/74A patent/FI60210C/en active
- 1974-11-18 IE IE2366/74A patent/IE40122B1/en unknown
- 1974-11-21 YU YU3104/74A patent/YU36736B/en unknown
- 1974-11-25 CA CA214,541A patent/CA1041481A/en not_active Expired
- 1974-11-25 GB GB50969/74A patent/GB1480757A/en not_active Expired
- 1974-11-26 ES ES432305A patent/ES432305A1/en not_active Expired
- 1974-11-27 AR AR256686A patent/AR211234A1/en active
- 1974-11-27 DD DD182615A patent/DD115125A5/xx unknown
- 1974-11-28 IT IT54286/74A patent/IT1043920B/en active
- 1974-11-28 CH CH1580874A patent/CH618443A5/en not_active IP Right Cessation
- 1974-11-28 FR FR7439044A patent/FR2253022B1/fr not_active Expired
- 1974-11-29 DE DE2456528A patent/DE2456528C2/en not_active Expired
- 1974-11-29 HU HUME1803A patent/HU168823B/hu unknown
- 1974-11-30 JP JP49136660A patent/JPS6020393B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL187023B (en) | 1990-12-03 |
NL187023C (en) | 1991-05-01 |
DK153154C (en) | 1988-10-24 |
FI60210C (en) | 1981-12-10 |
FI60210B (en) | 1981-08-31 |
FR2253022B1 (en) | 1978-07-07 |
DE2456528C2 (en) | 1986-01-16 |
AU7550474A (en) | 1976-05-20 |
NO147839B (en) | 1983-03-14 |
GB1480757A (en) | 1977-07-27 |
YU310474A (en) | 1981-11-13 |
SE7414249L (en) | 1975-05-31 |
YU36736B (en) | 1984-08-31 |
HU168823B (en) | 1976-07-28 |
CH618443A5 (en) | 1980-07-31 |
IE40122L (en) | 1975-05-30 |
IE40122B1 (en) | 1979-03-14 |
FI330174A (en) | 1975-05-31 |
SE432934B (en) | 1984-04-30 |
DE2456528A1 (en) | 1975-06-05 |
IT1043920B (en) | 1980-02-29 |
NO147839C (en) | 1983-06-22 |
AR211234A1 (en) | 1977-11-15 |
NO744088L (en) | 1975-06-23 |
FR2253022A1 (en) | 1975-06-27 |
DD115125A5 (en) | 1975-09-12 |
CA1041481A (en) | 1978-10-31 |
JPS50105687A (en) | 1975-08-20 |
JPS6020393B2 (en) | 1985-05-21 |
NL7414820A (en) | 1975-06-03 |
DK589474A (en) | 1975-07-28 |
DK153154B (en) | 1988-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES477695A1 (en) | Derivatives of dehydrocyclicimino acids | |
ES427859A1 (en) | Antibiotics | |
ES469425A1 (en) | N-Alkyl-N-acyl derivatives of thienamycin | |
GB1048084A (en) | Benzanilide derivatives | |
ES426003A1 (en) | {60 -amino-{60 -(ureidophenyl)acetamidocephalosporins | |
GB1291675A (en) | 0-(1,3,4-thiadiazol-2-yl)-imidazolidinone(2) derivatives, process for their production and their use as herbicidal agents | |
ES412859A1 (en) | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof | |
GB1521073A (en) | Cephalosporin compounds | |
ES430428A1 (en) | D-homosteroids | |
CA1029744A (en) | Process for the production of novel aromatic carboxylic amide derivatives | |
ES432305A1 (en) | Preparation of 7-acylamino cephalosporin derivatives | |
GB1471847A (en) | Dibenzofuran derivatives | |
ES8601214A1 (en) | Cephalosporin derivatives and process for their preparation. | |
ES479570A1 (en) | 7 alpha -Methoxycephalosporin derivatives and their pharmaceutical compositions having antibacterial activity | |
GB1547473A (en) | Cephalosporin compounds | |
SE7612961L (en) | TIENAMYCIN DERIVATIVES | |
ES449142A1 (en) | Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins | |
GB1557423A (en) | Cephalosporins | |
ES437182A1 (en) | Cephalosporin compounds | |
IE44393L (en) | Cephalosporin compounds. | |
IE37678B1 (en) | 1,6-and 1,5-anhydrofuranose derivatives and processes for their manufacture | |
IE43666L (en) | Cephalosporin derivatives. | |
GB1452891A (en) | Tricyclic tetrazole derivatives their synthesis and compositions containing them | |
JPS5646885A (en) | Novel cephamycin ester and its preparation | |
ES417884A1 (en) | Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970210 |