GB1419995A - Process for preparing p-dihydroxy benzene disulphonic acid derivatives - Google Patents
Process for preparing p-dihydroxy benzene disulphonic acid derivativesInfo
- Publication number
- GB1419995A GB1419995A GB2114173A GB2114173A GB1419995A GB 1419995 A GB1419995 A GB 1419995A GB 2114173 A GB2114173 A GB 2114173A GB 2114173 A GB2114173 A GB 2114173A GB 1419995 A GB1419995 A GB 1419995A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydroxy benzene
- salts
- preparing
- cation
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NDGUAAJHDUBETK-UHFFFAOYSA-N 1,4-dihydroxycyclohexa-3,5-diene-1,2-disulfonic acid Chemical class OC1=CC(S(O)(=O)=O)C(O)(S(O)(=O)=O)C=C1 NDGUAAJHDUBETK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- -1 alkanolamine Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 2
- 150000001768 cations Chemical group 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- CTLTUPWEUCZSIP-UHFFFAOYSA-N 1,4-dihydroxycyclohexa-2,4-diene-1-sulfonic acid Chemical compound OC1=CCC(O)(S(O)(=O)=O)C=C1 CTLTUPWEUCZSIP-UHFFFAOYSA-N 0.000 abstract 1
- CJAZCKUGLFWINJ-UHFFFAOYSA-N 3,4-dihydroxybenzene-1,2-disulfonic acid Chemical class OC1=CC=C(S(O)(=O)=O)C(S(O)(=O)=O)=C1O CJAZCKUGLFWINJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010007191 Capillary fragility Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229940030225 antihemorrhagics Drugs 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002874 hemostatic agent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH732672A CH550148A (fr) | 1972-05-17 | 1972-05-17 | Procede de preparation de sels d'acides p-dihydroxybenzenedisulfoniques. |
| CH115473A CH558340A (en) | 1973-01-26 | 1973-01-26 | Dihydroxybenzenedisulphonic acid derivs - prepd from dihydroxybenzene - disulphonic acid and base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1419995A true GB1419995A (en) | 1976-01-07 |
Family
ID=25686824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2114173A Expired GB1419995A (en) | 1972-05-17 | 1973-05-03 | Process for preparing p-dihydroxy benzene disulphonic acid derivatives |
Country Status (15)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009083940A3 (en) * | 2008-01-03 | 2009-09-17 | Action Medicines S.L. | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH550148A (fr) * | 1972-05-17 | 1974-06-14 | Esteve Lab Del Dr Sa | Procede de preparation de sels d'acides p-dihydroxybenzenedisulfoniques. |
| CH591437A5 (enrdf_load_stackoverflow) * | 1974-05-08 | 1977-09-15 | Esteve Dr Lab Del Sa | |
| ZA745083B (en) * | 1973-09-11 | 1975-08-27 | Esteve Labor Dr | Process for the preparation of monoesters and diesters of 2,5-dihydroxy-benzene-sulphonic acid |
| CH591438A5 (enrdf_load_stackoverflow) * | 1975-05-16 | 1977-09-15 | Esteve Dr Lab Del Sa | |
| ES2015433A6 (es) * | 1989-08-03 | 1990-08-16 | Esteve Quimica Sa | Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico |
| FR2747040B1 (fr) * | 1996-04-03 | 1998-06-26 | Esteve Labor Dr | Derives 2,5-dihydroxybenzenesulfoniques comme medicaments pour normaliser la fonction endotheliale et la fonction sexuelle, et traiter les troubles vasculaires d'origine diabetique ou endotheliale |
| AU715600B2 (en) * | 1996-04-03 | 2000-02-03 | Laboratorios Del Dr. Esteve, S.A. | Use of 2,5-dihydroxybenzenesulfonic derivatives for the manufacture of medicaments intended for the normalization of the endothelial function, for the treatment of sexual dysfunction and vascular complications of diabetes, as well as vascular disorders of endothelial origin |
| LT5475B (lt) | 2006-04-12 | 2008-02-25 | Laboratorios Del Dr. Esteve, S. A. | 2,5-dihidroksibenzensulfoninių junginių panaudojimas sutrikimų, paremtų no produkcijos susilpnėjimu, gydymui ir/arba edhf funkcijos reguliavimo pablogėjimui |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3547988A (en) * | 1968-02-05 | 1970-12-15 | Eastman Kodak Co | Process for the preparation of dialkali dihydroxybenzene disulfonates |
-
1973
- 1973-01-01 AR AR247787A patent/AR204506A1/es active
- 1973-04-07 ES ES414365A patent/ES414365A1/es not_active Expired
- 1973-05-03 GB GB2114173A patent/GB1419995A/en not_active Expired
- 1973-05-10 CA CA170,960A patent/CA1024146A/en not_active Expired
- 1973-05-10 DE DE2323723A patent/DE2323723A1/de active Granted
- 1973-05-14 YU YU1264/73A patent/YU41547B/xx unknown
- 1973-05-15 RO RO7383592A patent/RO72544A/ro unknown
- 1973-05-15 RO RO7300074783A patent/RO62887A/ro unknown
- 1973-05-15 DD DD170840A patent/DD107025A5/xx unknown
- 1973-05-15 NL NLAANVRAGE7306734,A patent/NL179186C/xx active Search and Examination
- 1973-05-15 SE SE7306845A patent/SE416729B/xx unknown
- 1973-05-15 PL PL1973162553A patent/PL93785B1/pl unknown
- 1973-05-16 FR FR7317709A patent/FR2201888B1/fr not_active Expired
- 1973-05-17 CS CS733534A patent/CS194162B2/cs unknown
- 1973-05-17 JP JP5419273A patent/JPS5716982B2/ja not_active Expired
- 1973-05-17 HU HUEE2140A patent/HU169471B/hu not_active IP Right Cessation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009083940A3 (en) * | 2008-01-03 | 2009-09-17 | Action Medicines S.L. | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9012692B2 (en) | 2008-01-03 | 2015-04-21 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9227928B2 (en) | 2008-01-03 | 2016-01-05 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9801838B2 (en) | 2008-01-03 | 2017-10-31 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US10052294B2 (en) | 2008-01-03 | 2018-08-21 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US10632085B2 (en) | 2008-01-03 | 2020-04-28 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7306734A (enrdf_load_stackoverflow) | 1973-11-20 |
| NL179186C (nl) | 1986-08-01 |
| YU41547B (en) | 1987-10-31 |
| FR2201888A1 (enrdf_load_stackoverflow) | 1974-05-03 |
| DD107025A5 (enrdf_load_stackoverflow) | 1974-07-12 |
| RO62887A (fr) | 1978-02-15 |
| CS194162B2 (en) | 1979-11-30 |
| HU169471B (enrdf_load_stackoverflow) | 1976-11-28 |
| SE416729B (sv) | 1981-02-02 |
| AR204506A1 (es) | 1976-02-12 |
| ES414365A1 (es) | 1976-02-01 |
| CA1024146A (en) | 1978-01-10 |
| PL93785B1 (en) | 1977-06-30 |
| YU126473A (en) | 1982-02-28 |
| DE2323723C2 (enrdf_load_stackoverflow) | 1987-08-13 |
| DE2323723A1 (de) | 1973-11-29 |
| JPS5716982B2 (enrdf_load_stackoverflow) | 1982-04-08 |
| JPS4941518A (enrdf_load_stackoverflow) | 1974-04-18 |
| RO72544A (ro) | 1981-06-30 |
| FR2201888B1 (enrdf_load_stackoverflow) | 1977-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920503 |