GB1419995A - Process for preparing p-dihydroxy benzene disulphonic acid derivatives - Google Patents
Process for preparing p-dihydroxy benzene disulphonic acid derivativesInfo
- Publication number
- GB1419995A GB1419995A GB2114173A GB2114173A GB1419995A GB 1419995 A GB1419995 A GB 1419995A GB 2114173 A GB2114173 A GB 2114173A GB 2114173 A GB2114173 A GB 2114173A GB 1419995 A GB1419995 A GB 1419995A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydroxy benzene
- salts
- preparing
- cation
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1419995 Salts of dihydroxy benzene disulphonic acids LABORATORIOS DEL DR ESTEVE SA 3 May 1973 [17 May 1972 26 Jan 1973] 21141/73 Heading C2C The invention comprises novel salts (I) where B is a cation of an alkylamine, alkanolamine, arylamine, alkylarylamine, cyclic amine or an equivalent of an alkaline earth metal. The invention also comprises a process for preparing a p-dihydroxy benzene disulfonic acid which comprises dehydrating a salt of p-dihydroxy benzene monosulfonic acid by heating it in the presence of a liquid forming an azeotrope with water, distilling off the liquid/water azeotrope and sulfonating the residue of the anyhydrous mixture of the salt and solvents. The salts (I) are made by standard methods. Pharmaceutical preparations useful as hemostatic agents and for protecting capillary fragility contain (I) as active ingredient but where B is a cation of any nitrogen-containing base (including ammonia) or an alkali metal or an equivalent of an alkaline earth metal. Administration is orally or parenterally.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH732672A CH550148A (en) | 1972-05-17 | 1972-05-17 | Dihydroxybenzenedisulphonic acid derivs - prepd from dihydroxybenzene - disulphonic acid and base |
| CH115473A CH558340A (en) | 1973-01-26 | 1973-01-26 | Dihydroxybenzenedisulphonic acid derivs - prepd from dihydroxybenzene - disulphonic acid and base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1419995A true GB1419995A (en) | 1976-01-07 |
Family
ID=25686824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2114173A Expired GB1419995A (en) | 1972-05-17 | 1973-05-03 | Process for preparing p-dihydroxy benzene disulphonic acid derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5716982B2 (en) |
| AR (1) | AR204506A1 (en) |
| CA (1) | CA1024146A (en) |
| CS (1) | CS194162B2 (en) |
| DD (1) | DD107025A5 (en) |
| DE (1) | DE2323723A1 (en) |
| ES (1) | ES414365A1 (en) |
| FR (1) | FR2201888B1 (en) |
| GB (1) | GB1419995A (en) |
| HU (1) | HU169471B (en) |
| NL (1) | NL179186C (en) |
| PL (1) | PL93785B1 (en) |
| RO (2) | RO72544A (en) |
| SE (1) | SE416729B (en) |
| YU (1) | YU41547B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009083940A2 (en) * | 2008-01-03 | 2009-07-09 | Action Medicines S.L. | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH550148A (en) * | 1972-05-17 | 1974-06-14 | Esteve Lab Del Dr Sa | Dihydroxybenzenedisulphonic acid derivs - prepd from dihydroxybenzene - disulphonic acid and base |
| CH591437A5 (en) * | 1974-05-08 | 1977-09-15 | Esteve Dr Lab Del Sa | |
| ZA745083B (en) * | 1973-09-11 | 1975-08-27 | Esteve Labor Dr | Process for the preparation of monoesters and diesters of 2,5-dihydroxy-benzene-sulphonic acid |
| CH591438A5 (en) * | 1975-05-16 | 1977-09-15 | Esteve Dr Lab Del Sa | |
| ES2015433A6 (en) * | 1989-08-03 | 1990-08-16 | Esteve Quimica Sa | Process for preparing the piperazine salt of 2,5-dihydroxybenzenesulphonic acid monotosylate. |
| FR2747040B1 (en) * | 1996-04-03 | 1998-06-26 | Esteve Labor Dr | 2,5-DIHYDROXYBENZENESULFONIC DERIVATIVES AS MEDICAMENTS FOR NORMALIZING ENDOTHELIAL AND SEXUAL FUNCTION, AND TREATING VASCULAR DISORDERS OF DIABETIC OR ENDOTHELIAL ORIGIN |
| DE69735417T2 (en) * | 1996-04-03 | 2006-09-21 | Laboratorios Del Dr. Esteve S.A. | 2,5-DIHYDROXYBENZYLSULFON DERIVATIVES FOR THE TREATMENT OF SEXUAL DISORDERS |
| LT5475B (en) | 2006-04-12 | 2008-02-25 | Laboratorios Del Dr. Esteve, S. A. | Use of 2,5-dihidroxybenzenesulfonic compounds for the treatment of disorders based on an impairment of no production and/or of regulation of edhf function |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3547988A (en) * | 1968-02-05 | 1970-12-15 | Eastman Kodak Co | Process for the preparation of dialkali dihydroxybenzene disulfonates |
-
1973
- 1973-01-01 AR AR247787A patent/AR204506A1/en active
- 1973-04-07 ES ES414365A patent/ES414365A1/en not_active Expired
- 1973-05-03 GB GB2114173A patent/GB1419995A/en not_active Expired
- 1973-05-10 DE DE2323723A patent/DE2323723A1/en active Granted
- 1973-05-10 CA CA170,960A patent/CA1024146A/en not_active Expired
- 1973-05-14 YU YU1264/73A patent/YU41547B/en unknown
- 1973-05-15 RO RO7383592A patent/RO72544A/en unknown
- 1973-05-15 NL NLAANVRAGE7306734,A patent/NL179186C/en active Search and Examination
- 1973-05-15 DD DD170840A patent/DD107025A5/xx unknown
- 1973-05-15 SE SE7306845A patent/SE416729B/en unknown
- 1973-05-15 RO RO7300074783A patent/RO62887A/en unknown
- 1973-05-15 PL PL1973162553A patent/PL93785B1/en unknown
- 1973-05-16 FR FR7317709A patent/FR2201888B1/fr not_active Expired
- 1973-05-17 JP JP5419273A patent/JPS5716982B2/ja not_active Expired
- 1973-05-17 CS CS733534A patent/CS194162B2/en unknown
- 1973-05-17 HU HUEE2140A patent/HU169471B/hu not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009083940A2 (en) * | 2008-01-03 | 2009-07-09 | Action Medicines S.L. | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| WO2009083940A3 (en) * | 2008-01-03 | 2009-09-17 | Action Medicines S.L. | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9012692B2 (en) | 2008-01-03 | 2015-04-21 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9227928B2 (en) | 2008-01-03 | 2016-01-05 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US9801838B2 (en) | 2008-01-03 | 2017-10-31 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US10052294B2 (en) | 2008-01-03 | 2018-08-21 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US10632085B2 (en) | 2008-01-03 | 2020-04-28 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
Also Published As
| Publication number | Publication date |
|---|---|
| CS194162B2 (en) | 1979-11-30 |
| YU41547B (en) | 1987-10-31 |
| RO62887A (en) | 1978-02-15 |
| DE2323723A1 (en) | 1973-11-29 |
| CA1024146A (en) | 1978-01-10 |
| RO72544A (en) | 1981-06-30 |
| FR2201888B1 (en) | 1977-01-21 |
| ES414365A1 (en) | 1976-02-01 |
| YU126473A (en) | 1982-02-28 |
| JPS4941518A (en) | 1974-04-18 |
| PL93785B1 (en) | 1977-06-30 |
| SE416729B (en) | 1981-02-02 |
| HU169471B (en) | 1976-11-28 |
| FR2201888A1 (en) | 1974-05-03 |
| NL7306734A (en) | 1973-11-20 |
| DE2323723C2 (en) | 1987-08-13 |
| AR204506A1 (en) | 1976-02-12 |
| DD107025A5 (en) | 1974-07-12 |
| NL179186C (en) | 1986-08-01 |
| JPS5716982B2 (en) | 1982-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1140508A (en) | Improvements relating to isopropanolamine derivatives and their production | |
| GB1419995A (en) | Process for preparing p-dihydroxy benzene disulphonic acid derivatives | |
| GB970886A (en) | New pyridines and process for the manufacture thereof | |
| SE7701624L (en) | PROCEDURE FOR PREPARING NEW FORMS OF PRAZOSIN HYDROCHLORIDE | |
| TNSN88073A1 (en) | NOVEL N - (3-HYDROXY-PIPERIDINYL) BENZAMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THE PREPARATION THEREOF | |
| GB1111451A (en) | Improvements in or relating to pharmacologically-active secondary amine compounds | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| GB1415471A (en) | Phenylethylamine derivatives | |
| GB986580A (en) | 5-substituted dibenzocycloheptadienes | |
| GB808425A (en) | Improvements in or relating to the separation of aromatic amines | |
| GB1409948A (en) | Oligoethylenepiperazines | |
| GB1211459A (en) | Hydroxy amines | |
| GB1138968A (en) | Improvements in or relating to indole derivatives | |
| GB1348258A (en) | 9-oxo-6.9-dihydro-4h-dioxino-4,5-g-quinolyl-8-carboxylic acids and their isomers, 10-oxo-7,10-dihydro-1h-dioxino-5,4-f-quinolyl- 9-carboxylic acids | |
| GB1126994A (en) | Guanidine derivatives and processes for preparing the same | |
| ES407866A1 (en) | Preparation of n -diethylaminoethyl - 2 - methoxy- 5 - methyl sulphonylbenzamide | |
| GB1083076A (en) | A process for resolving d,l-pantolactone | |
| GB1490247A (en) | Process for preparing mono-and di-esters of 2,5-dihydroxybenzene sulphonic acid | |
| SU124433A3 (en) | The method of synthesis of steroid bases and their salts of General formula A | |
| GB1093971A (en) | Improvements in novel mercury compound | |
| ES418461A1 (en) | 2,2{40 -Anhydro-1-{62 D-arabinofuranosyl-5-fluorocytosine salts and process 2 | |
| GB790557A (en) | Piperazine derivatives | |
| GB1260985A (en) | DEW DERIVATIVES OF p-HYDROXY-PHENYLBUTAZONE | |
| GB893965A (en) | Improved preparations for azoic coupling components | |
| GB1153973A (en) | alpha,alpha-Diphenyl-beta-Methyl-1-Azaspiro[4,5]Decane (and [4,4]Nonane)-1-Propanols |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920503 |