ES2015433A6 - Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico - Google Patents

Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico

Info

Publication number
ES2015433A6
ES2015433A6 ES8902754A ES8902754A ES2015433A6 ES 2015433 A6 ES2015433 A6 ES 2015433A6 ES 8902754 A ES8902754 A ES 8902754A ES 8902754 A ES8902754 A ES 8902754A ES 2015433 A6 ES2015433 A6 ES 2015433A6
Authority
ES
Spain
Prior art keywords
monotosylate
salt
piperazine
preparing
dihydroxybenzenesulphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8902754A
Other languages
English (en)
Inventor
Giral Salvador Mirallas
Pons De Vall Josep Mar Fabrega
Baro Miquel Ribalta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to ES8902754A priority Critical patent/ES2015433A6/es
Priority to US07/557,918 priority patent/US5082941A/en
Priority to JP2201030A priority patent/JPH0366662A/ja
Priority to EP19900402205 priority patent/EP0412011A3/en
Priority to CA002022618A priority patent/CA2022618A1/en
Publication of ES2015433A6 publication Critical patent/ES2015433A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE LA SAL DE PIPERACINA DEL MOTOSILATO DEL ACIDO 2,5-DIHIDROXIBENCENOSULFONICO. SE CARACTERIZA PORQUE SE UTILIZA COMO MATERIAL DE PARTIDA LA SAL DE DIETILAMINA O LA SAL DE AMONIO DEL ACIDO 2,5-DIHIDROXIBENCENOSULFONICO, LA CUAL ES TOSILADA EN MEDIO AMONIACAL PARA CONDUCIR EN AMBOS CASOS A LA OBTENCION DE LA SAL AMONIO DEL MONOTOSILATO DEL ACIDO 2,5-DIHIDROXIBENCENOSULFONICO, LA CUAL A SU VEZ SE CONVIERTE INICIALMENTE EN LA DISAL DE PIPERACINA CORRESPONDIENTE QUE SE SEPARA EN MEDIO ACUOSO Y FINALMENTE EN MEDIO HIDROALCOHOLICO SE OBTIENE LA SAL DE PIPERACINA DEL MONOTOSILATO DEL ACIDO 2,5-DIHIDROXIBENCENOSULFONICO, TAMBIEN CONOCIDA COMO SULTOSILATO DE PIPERACINA. APLICACIONES MEDICINALES.
ES8902754A 1989-08-03 1989-08-03 Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico Expired - Lifetime ES2015433A6 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES8902754A ES2015433A6 (es) 1989-08-03 1989-08-03 Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico
US07/557,918 US5082941A (en) 1989-08-03 1990-07-25 Process for preparing the piperazine salt of 2,5-dihydroxybenzenesulphonic acid monotosylate
JP2201030A JPH0366662A (ja) 1989-08-03 1990-07-27 ２，５―ジヒドロキシベンゼンスルホン酸モノトシラートピペラジン塩の製造法
EP19900402205 EP0412011A3 (en) 1989-08-03 1990-08-01 Process for preparing the piperazine salt of 2,5-dihydroxybenzenesulphonic acid monotosylate
CA002022618A CA2022618A1 (en) 1989-08-03 1990-08-02 Process for preparing the piperazine salt of 2,5-dihydroxybenzenesulphonic acid monotosylate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8902754A ES2015433A6 (es) 1989-08-03 1989-08-03 Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico

Publications (1)

Publication Number Publication Date
ES2015433A6 true ES2015433A6 (es) 1990-08-16

Family

ID=8263440

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8902754A Expired - Lifetime ES2015433A6 (es) 1989-08-03 1989-08-03 Procedimientos de preparacion de la sal de piperacina del monotosilato del acido 2,5-dihidroxibencenosulfonico

Country Status (5)

Country Link
US (1) US5082941A (es)
EP (1) EP0412011A3 (es)
JP (1) JPH0366662A (es)
CA (1) CA2022618A1 (es)
ES (1) ES2015433A6 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020040A2 (en) 2006-08-16 2008-02-21 Action Medicines, S.L. 2,5-dihydroxybenzene compounds for the treatment of fibrosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204506A1 (es) * 1972-05-17 1976-02-12 Esteve Labor Dr Procedimiento de preparacion de sales de acidos p-dihidroxibencenodisulfonicos
US3954767A (en) * 1972-05-17 1976-05-04 Esteve Subirana Antonio Piperazine salts of 2,5-dihydroxy benzene sulfonic acid mono- and diesters
CH563356A5 (es) * 1972-05-17 1975-06-30 Esteve Dr Lab Del Sa
CH591437A5 (es) * 1974-05-08 1977-09-15 Esteve Dr Lab Del Sa
ZA745083B (en) * 1973-09-11 1975-08-27 Esteve Labor Dr Process for the preparation of monoesters and diesters of 2,5-dihydroxy-benzene-sulphonic acid
US4115648A (en) * 1974-09-13 1978-09-19 Laboratorios Del Dr. Esteve, S.A. 2,5-Dihydroxy benzene sulfonic acid mono esters
IT8222600A0 (it) * 1982-07-28 1982-07-28 Pietro Tommaso Tessitore Nuovi idrossibenzensolfonati della 5-(o-clorobenzil)-4,5,6,7-tetraidro tieno parentesi quadra aperta 3,2-c parentesi quadra chiusa piridina.

Also Published As

Publication number Publication date
EP0412011A2 (en) 1991-02-06
CA2022618A1 (en) 1991-02-04
JPH0366662A (ja) 1991-03-22
EP0412011A3 (en) 1991-04-17
US5082941A (en) 1992-01-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100412