GB1400999A - Imidazo-triazine compounds and their use in therapeutic compositions - Google Patents
Imidazo-triazine compounds and their use in therapeutic compositionsInfo
- Publication number
- GB1400999A GB1400999A GB5375071A GB5375071A GB1400999A GB 1400999 A GB1400999 A GB 1400999A GB 5375071 A GB5375071 A GB 5375071A GB 5375071 A GB5375071 A GB 5375071A GB 1400999 A GB1400999 A GB 1400999A
- Authority
- GB
- United Kingdom
- Prior art keywords
- imidazo
- aerosol
- group
- therapeutic compositions
- triazine compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE791025D BE791025A (fr) | 1971-11-19 | Composes heterocycliques | |
GB5375071A GB1400999A (en) | 1971-11-19 | 1971-11-19 | Imidazo-triazine compounds and their use in therapeutic compositions |
DK525172AA DK138691B (da) | 1971-11-19 | 1972-10-23 | Analogifremgangsmåde til fremstilling af imidazo(5,1-f)triazinoner eller salte deraf. |
IE1433/72A IE37046B1 (en) | 1971-11-19 | 1972-10-23 | Imidazo-triazine compounds and their use in therapeutic compositions |
ZA727532A ZA727532B (en) | 1971-11-19 | 1972-10-23 | Heterocyclic compounds |
US00300749A US3840537A (en) | 1971-11-19 | 1972-10-25 | Imidazo(5,1-f)triazinones |
AU48191/72A AU472127B2 (en) | 1971-11-19 | 1972-10-26 | Heterocyclic compounds |
IL40686A IL40686A (en) | 1971-11-19 | 1972-10-27 | 2-amino-imidazo(5,1-f)-as-triazin-4(3h)-ones,their preparation and pharmaceutical compositions containing them |
CA155,720A CA990292A (en) | 1971-11-19 | 1972-11-01 | Imidazo-triazinones |
SE7214358A SE402915B (sv) | 1971-11-19 | 1972-11-06 | Forfarande for framstellning av imidazo(5,1-f)triazinoner med terapeutisk verkan |
FR7239498A FR2160407B1 (xx) | 1971-11-19 | 1972-11-08 | |
DE2255172A DE2255172A1 (de) | 1971-11-19 | 1972-11-10 | Imidazotriazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate |
PH14090*UA PH9669A (en) | 1971-11-19 | 1972-11-16 | Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use |
CH1668372A CH594671A5 (xx) | 1971-11-19 | 1972-11-16 | |
JP11549572A JPS563873B2 (xx) | 1971-11-19 | 1972-11-17 | |
AT982372A AT321923B (de) | 1971-11-19 | 1972-11-17 | Verfahren zur herstellung von neuen imidazotriazinonen |
NL7215646A NL7215646A (xx) | 1971-11-19 | 1972-11-17 | |
ES408736A ES408736A1 (es) | 1971-11-19 | 1972-11-17 | Procedimiento para la preparacion de compuestos imidazo- triazinonas. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5375071A GB1400999A (en) | 1971-11-19 | 1971-11-19 | Imidazo-triazine compounds and their use in therapeutic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1400999A true GB1400999A (en) | 1975-07-16 |
Family
ID=10468856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5375071A Expired GB1400999A (en) | 1971-11-19 | 1971-11-19 | Imidazo-triazine compounds and their use in therapeutic compositions |
Country Status (18)
Country | Link |
---|---|
US (1) | US3840537A (xx) |
JP (1) | JPS563873B2 (xx) |
AT (1) | AT321923B (xx) |
AU (1) | AU472127B2 (xx) |
BE (1) | BE791025A (xx) |
CA (1) | CA990292A (xx) |
CH (1) | CH594671A5 (xx) |
DE (1) | DE2255172A1 (xx) |
DK (1) | DK138691B (xx) |
ES (1) | ES408736A1 (xx) |
FR (1) | FR2160407B1 (xx) |
GB (1) | GB1400999A (xx) |
IE (1) | IE37046B1 (xx) |
IL (1) | IL40686A (xx) |
NL (1) | NL7215646A (xx) |
PH (1) | PH9669A (xx) |
SE (1) | SE402915B (xx) |
ZA (1) | ZA727532B (xx) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0009384A1 (en) * | 1978-09-18 | 1980-04-02 | Glaxo Group Limited | Processes for the preparation of triazinones and condensed triazinones, and compounds so obtained |
US4278673A (en) * | 1977-03-25 | 1981-07-14 | Allen & Hanburys Limited | Pharmacologically active compounds |
US5498774A (en) * | 1989-06-23 | 1996-03-12 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
WO2016147659A1 (en) * | 2015-03-16 | 2016-09-22 | Sumitomo Dainippon Pharma Co., Ltd. | Bicyclic imidazolo derivative |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1457873A (en) * | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
DE2314488C3 (de) * | 1973-03-23 | 1979-01-04 | C.H. Boehringer Sohn, 6507 Ingelheim | 8-(2,6-Dichlorphenyl)-7-(4-chlorphenyl)-5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazin, Verfahren zu dessen Herstellung und dieses enthaltene Arzneimittel |
DE2335193A1 (de) * | 1973-07-11 | 1975-01-30 | Hoechst Ag | Bis-triazinobenzimidazole und ihre herstellung |
US4107307A (en) * | 1977-02-03 | 1978-08-15 | American Cyanamid Company | Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones |
US4115572A (en) * | 1977-02-03 | 1978-09-19 | American Cyanamid Company | Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma |
USRE30511E (en) * | 1977-02-03 | 1981-02-10 | American Cyanamid Company | Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones |
US4107308A (en) * | 1977-10-18 | 1978-08-15 | American Cyanamid Company | Imidazo[1,5-d]-as-triazines |
HU187474B (en) * | 1981-11-18 | 1986-01-28 | Gyogyszerkutato Intezet,Hu | Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives |
US4395547A (en) * | 1982-02-10 | 1983-07-26 | American Cyanamid Co. | Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones |
US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
ATE213246T1 (de) * | 1997-11-12 | 2002-02-15 | 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren | |
DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
IL141335A0 (en) | 1998-08-26 | 2002-03-10 | Smithkline Beecham Corp | Therapies for treating pulmonary diseases |
EA006685B1 (ru) | 1999-08-21 | 2006-02-24 | Алтана Фарма Аг | Синергетическая композиция |
DK1392314T3 (da) * | 2001-05-09 | 2007-03-12 | Bayer Healthcare Ag | Hidtil ukendt anvendelse af 2-[2-ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-on |
GB0113343D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 2 |
GB0113344D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel heterocycles 3 |
DE10135815A1 (de) | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
DE10232113A1 (de) * | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
ES2326808T3 (es) * | 2003-04-01 | 2009-10-20 | Smithkline Beecham Corporation | Compuestos de imidazotriazina para el tratamiento de enfermedades cancerosas. |
EP2168968B1 (en) | 2004-04-02 | 2017-08-23 | OSI Pharmaceuticals, LLC | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
BRPI0616633A2 (pt) * | 2005-09-29 | 2011-06-28 | Bayer Healthcare Ag | inibidores de pde e combinações dos mesmos para o tratamento de transtornos urológicos |
EP1951724B1 (en) * | 2005-11-17 | 2011-04-27 | OSI Pharmaceuticals, Inc. | FUSED BICYCLIC mTOR INHIBITORS |
KR20100029762A (ko) * | 2007-06-13 | 2010-03-17 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 청력 장애 치료용 pde 억제제 |
CN102405214A (zh) | 2009-04-20 | 2012-04-04 | Osi药物有限责任公司 | C-吡嗪-甲胺的制备 |
CN103374002B (zh) * | 2012-04-19 | 2015-07-15 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-5抑制剂 |
WO2017000276A1 (en) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
WO2017204316A1 (ja) * | 2016-05-27 | 2017-11-30 | 塩野義製薬株式会社 | 5-オキソ-1,2,4-トリアジン誘導体およびその医薬組成物 |
-
0
- BE BE791025D patent/BE791025A/xx unknown
-
1971
- 1971-11-19 GB GB5375071A patent/GB1400999A/en not_active Expired
-
1972
- 1972-10-23 ZA ZA727532A patent/ZA727532B/xx unknown
- 1972-10-23 IE IE1433/72A patent/IE37046B1/xx unknown
- 1972-10-23 DK DK525172AA patent/DK138691B/da unknown
- 1972-10-25 US US00300749A patent/US3840537A/en not_active Expired - Lifetime
- 1972-10-26 AU AU48191/72A patent/AU472127B2/en not_active Expired
- 1972-10-27 IL IL40686A patent/IL40686A/xx unknown
- 1972-11-01 CA CA155,720A patent/CA990292A/en not_active Expired
- 1972-11-06 SE SE7214358A patent/SE402915B/xx unknown
- 1972-11-08 FR FR7239498A patent/FR2160407B1/fr not_active Expired
- 1972-11-10 DE DE2255172A patent/DE2255172A1/de not_active Withdrawn
- 1972-11-16 PH PH14090*UA patent/PH9669A/en unknown
- 1972-11-16 CH CH1668372A patent/CH594671A5/xx not_active IP Right Cessation
- 1972-11-17 NL NL7215646A patent/NL7215646A/xx not_active Application Discontinuation
- 1972-11-17 JP JP11549572A patent/JPS563873B2/ja not_active Expired
- 1972-11-17 ES ES408736A patent/ES408736A1/es not_active Expired
- 1972-11-17 AT AT982372A patent/AT321923B/de not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4278673A (en) * | 1977-03-25 | 1981-07-14 | Allen & Hanburys Limited | Pharmacologically active compounds |
EP0009384A1 (en) * | 1978-09-18 | 1980-04-02 | Glaxo Group Limited | Processes for the preparation of triazinones and condensed triazinones, and compounds so obtained |
US5498774A (en) * | 1989-06-23 | 1996-03-12 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
WO2016147659A1 (en) * | 2015-03-16 | 2016-09-22 | Sumitomo Dainippon Pharma Co., Ltd. | Bicyclic imidazolo derivative |
Also Published As
Publication number | Publication date |
---|---|
FR2160407B1 (xx) | 1975-10-17 |
DK138691C (xx) | 1979-03-26 |
AU472127B2 (en) | 1976-05-20 |
US3840537A (en) | 1974-10-08 |
DK138691B (da) | 1978-10-16 |
AU4819172A (en) | 1974-05-16 |
ZA727532B (en) | 1973-07-25 |
CH594671A5 (xx) | 1978-01-13 |
ES408736A1 (es) | 1976-03-01 |
IE37046L (en) | 1973-05-19 |
AT321923B (de) | 1975-04-25 |
IL40686A0 (en) | 1972-12-29 |
DE2255172A1 (de) | 1973-05-24 |
IL40686A (en) | 1975-12-31 |
PH9669A (en) | 1976-02-10 |
SE402915B (sv) | 1978-07-24 |
JPS563873B2 (xx) | 1981-01-27 |
BE791025A (fr) | 1973-05-07 |
CA990292A (en) | 1976-06-01 |
NL7215646A (xx) | 1973-05-22 |
JPS4857993A (xx) | 1973-08-14 |
IE37046B1 (en) | 1977-04-27 |
FR2160407A1 (xx) | 1973-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |