GB1384372A - Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids - Google Patents
Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acidsInfo
- Publication number
- GB1384372A GB1384372A GB278771A GB278771A GB1384372A GB 1384372 A GB1384372 A GB 1384372A GB 278771 A GB278771 A GB 278771A GB 278771 A GB278771 A GB 278771A GB 1384372 A GB1384372 A GB 1384372A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- alkyl
- ene
- novel
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000008064 anhydrides Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- -1 hydroxyalkyl ester Chemical class 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003128 pregnanes Chemical class 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Steroid Compounds (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB278771A GB1384372A (en) | 1971-01-20 | 1971-01-20 | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
IL38589A IL38589A (en) | 1971-01-20 | 1972-01-19 | 11beta-hydroxy-17alpha-acyloxy-3-oxo-androst-4-ene-17beta-carboxylic acid esters |
NO111/72A NO137321C (no) | 1971-01-20 | 1972-01-19 | Analogifremgangsm}te for fremstilling av terapeutisk aktive 3-okso-17alfa-acyloksyandrost-4-en-17beta-karboksylsyreestere |
CA132,814A CA1003820A (en) | 1971-01-20 | 1972-01-20 | Steroid compounds |
CH84372A CH602786A5 (xx) | 1971-01-20 | 1972-01-20 | |
SE7200662A SE383522B (sv) | 1971-01-20 | 1972-01-20 | Forfarande for framstellning av anti-inflammatoriskt verksamma 17-karboxylat av steroider tillhorande androstan-serien. |
BE778285A BE778285A (fr) | 1971-01-20 | 1972-01-20 | Composes steroides a activite anti-phlogistique |
NLAANVRAGE7200818,A NL172511C (nl) | 1971-01-20 | 1972-01-20 | Werkwijze voor het bereiden of vervaardigen van een geneesmiddel tegen ontstekingen. |
ES399057A ES399057A1 (es) | 1971-01-20 | 1972-01-20 | Procedimiento para preparar compuestos esteroides que tie- nen propiedades anti-inflamatorias. |
DE19722202691 DE2202691A1 (de) | 1971-01-20 | 1972-01-20 | Steroidverbindungen |
ZA720401A ZA72401B (en) | 1971-01-20 | 1972-01-20 | Steroid compounds |
AU38110/72A AU473868B2 (en) | 1971-01-20 | 1972-01-20 | Steroid compounds |
FR7201852A FR2122539B1 (xx) | 1971-01-20 | 1972-01-20 | |
DK29672*#A DK132894C (da) | 1971-01-20 | 1972-01-20 | Analogifremgangsmade til fremstilling af 3-oxo-17alfa-acyloxyandrost-4-en-17beta-carboxylsyreestere |
IE82/72A IE36000B1 (en) | 1971-01-20 | 1972-01-20 | Derivatives of 17alpha-hydroxy-androst-4-ene-17beta-carboxylic acids |
JP735572A JPS5611720B1 (xx) | 1971-01-20 | 1972-01-20 | |
HK342/78A HK34278A (en) | 1971-01-20 | 1978-06-29 | Derivatives of 17alpha-hydroxy-androst-4ene-17beta-carboxylic acids |
MY308/78A MY7800308A (en) | 1971-01-20 | 1978-12-30 | Derivatives of 17(alpha)-hydroxy-androst-4-ene-17(beta)-carboxylic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB278771A GB1384372A (en) | 1971-01-20 | 1971-01-20 | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1384372A true GB1384372A (en) | 1975-02-19 |
Family
ID=9745890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB278771A Expired GB1384372A (en) | 1971-01-20 | 1971-01-20 | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5611720B1 (xx) |
AU (1) | AU473868B2 (xx) |
BE (1) | BE778285A (xx) |
CA (1) | CA1003820A (xx) |
CH (1) | CH602786A5 (xx) |
DE (1) | DE2202691A1 (xx) |
DK (1) | DK132894C (xx) |
ES (1) | ES399057A1 (xx) |
FR (1) | FR2122539B1 (xx) |
GB (1) | GB1384372A (xx) |
HK (1) | HK34278A (xx) |
IE (1) | IE36000B1 (xx) |
IL (1) | IL38589A (xx) |
NL (1) | NL172511C (xx) |
NO (1) | NO137321C (xx) |
SE (1) | SE383522B (xx) |
ZA (1) | ZA72401B (xx) |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2422688A1 (fr) * | 1978-02-08 | 1979-11-09 | Glaxo Group Ltd | Steroide antiphlogistique de la serie de l'androstane |
US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
WO2002000679A2 (en) * | 2000-06-28 | 2002-01-03 | Novartis Ag | 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
WO2005005451A1 (en) | 2003-07-11 | 2005-01-20 | Glaxo Group Limited | Specific glucocorticosteroid compound having anti- inflammatory activity |
US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6878698B2 (en) | 2001-04-07 | 2005-04-12 | Glaxo Group Limited | Anti-inflammatory androstane derivatives |
US7125985B2 (en) | 2000-08-05 | 2006-10-24 | Glaxo Group Limited | Compounds useful in the manufacture of an anti-inflammatory androstane derivative |
US7291608B2 (en) | 2001-04-30 | 2007-11-06 | Glaxo Group Limited | Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α |
US7419971B2 (en) | 2003-06-19 | 2008-09-02 | Bodor Nicholas S | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids for topical or other local application |
US7498321B2 (en) | 2000-08-05 | 2009-03-03 | Glaxo Group Limited | 17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
US7560448B2 (en) | 2003-06-19 | 2009-07-14 | Bodor Nicholas S | Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application |
US7579335B2 (en) | 2005-01-10 | 2009-08-25 | Glaxo Group Limited | Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
US7687484B2 (en) | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
US7691811B2 (en) | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
US8163723B2 (en) | 2002-06-14 | 2012-04-24 | Cipla Limited | Combination of azelastine and steroids |
US8835410B2 (en) | 2011-05-10 | 2014-09-16 | Bodor Laboratories, Inc. | Treatment of eyelid dermatitis |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
DE2365102C2 (de) * | 1973-12-21 | 1982-12-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue Pregnansäure-Derivate |
DE2444618C2 (de) * | 1974-09-16 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue Pregnan-21-säure-Derivate |
DE2319479C2 (de) * | 1973-04-14 | 1982-10-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Pregnansäure-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
SE427276B (sv) * | 1975-04-03 | 1983-03-21 | Hoffmann La Roche | Forfarande for framstellning av d-homosteroider |
CH628355A5 (de) * | 1976-02-24 | 1982-02-26 | Ciba Geigy Ag | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
CA1138857A (en) * | 1979-01-24 | 1983-01-04 | Leo Alig | D-homosteroids |
SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
JPS59139315A (ja) * | 1983-01-31 | 1984-08-10 | Taisho Pharmaceut Co Ltd | クリ−ム剤 |
US4607028A (en) * | 1983-08-18 | 1986-08-19 | Ciba-Geigy Corporation | Novel carboxylic acid esters |
DE102010029875A1 (de) | 2010-06-09 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 1,4-Pregna-diensäure-Derivaten |
DE102010029877A1 (de) | 2010-06-09 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 1,4-Pregna-diensäure-Derivaten |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3636010A (en) * | 1968-12-23 | 1972-01-18 | Ciba Geigy Corp | Esters of steroid-17-carboxylic acids |
-
1971
- 1971-01-20 GB GB278771A patent/GB1384372A/en not_active Expired
-
1972
- 1972-01-19 IL IL38589A patent/IL38589A/en unknown
- 1972-01-19 NO NO111/72A patent/NO137321C/no unknown
- 1972-01-20 NL NLAANVRAGE7200818,A patent/NL172511C/xx not_active IP Right Cessation
- 1972-01-20 FR FR7201852A patent/FR2122539B1/fr not_active Expired
- 1972-01-20 CA CA132,814A patent/CA1003820A/en not_active Expired
- 1972-01-20 IE IE82/72A patent/IE36000B1/xx unknown
- 1972-01-20 CH CH84372A patent/CH602786A5/xx not_active IP Right Cessation
- 1972-01-20 DK DK29672*#A patent/DK132894C/da active
- 1972-01-20 ES ES399057A patent/ES399057A1/es not_active Expired
- 1972-01-20 DE DE19722202691 patent/DE2202691A1/de not_active Ceased
- 1972-01-20 ZA ZA720401A patent/ZA72401B/xx unknown
- 1972-01-20 AU AU38110/72A patent/AU473868B2/en not_active Expired
- 1972-01-20 BE BE778285A patent/BE778285A/xx not_active IP Right Cessation
- 1972-01-20 JP JP735572A patent/JPS5611720B1/ja active Pending
- 1972-01-20 SE SE7200662A patent/SE383522B/xx unknown
-
1978
- 1978-06-29 HK HK342/78A patent/HK34278A/xx unknown
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2422688A1 (fr) * | 1978-02-08 | 1979-11-09 | Glaxo Group Ltd | Steroide antiphlogistique de la serie de l'androstane |
US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
US6921757B2 (en) | 2000-06-28 | 2005-07-26 | Novartis Ag | Organic compounds |
WO2002000679A2 (en) * | 2000-06-28 | 2002-01-03 | Novartis Ag | 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group |
WO2002000679A3 (en) * | 2000-06-28 | 2002-03-28 | Novartis Ag | 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group |
CZ302513B6 (cs) * | 2000-06-28 | 2011-06-29 | Novartis Ag | Steroid, farmaceutická kompozice tento steroid obsahující, zpusob prípravy tohoto steroidu a meziprodukty pro tento zpusob |
US7125985B2 (en) | 2000-08-05 | 2006-10-24 | Glaxo Group Limited | Compounds useful in the manufacture of an anti-inflammatory androstane derivative |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US7531528B2 (en) | 2000-08-05 | 2009-05-12 | Glaxo Group Limited | Formulation containing anti-inflammatory androstane derivatives |
US7498321B2 (en) | 2000-08-05 | 2009-03-03 | Glaxo Group Limited | 17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US7132532B2 (en) | 2000-08-05 | 2006-11-07 | Glaxo Group Limited | Compounds useful in the manufacture of an anti-inflammatory androstane derivative |
US7144845B2 (en) | 2000-08-05 | 2006-12-05 | Glaxo Group Limited | Compounds useful in the manufacture of an anti-inflammatory androstane derivative |
US7629335B2 (en) | 2000-08-05 | 2009-12-08 | Glaxo Group Limited | Anti-inflammatory androstane derivative |
US7541350B2 (en) | 2000-08-05 | 2009-06-02 | Glaxo Group Limited | Formulation containing anti-inflammatory androstane derivative |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6878698B2 (en) | 2001-04-07 | 2005-04-12 | Glaxo Group Limited | Anti-inflammatory androstane derivatives |
US7291608B2 (en) | 2001-04-30 | 2007-11-06 | Glaxo Group Limited | Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α |
US7592329B2 (en) | 2002-02-04 | 2009-09-22 | Glaxo Group Limited | Crystalline complexes of fluticasone-2-furoate |
US8318709B2 (en) | 2002-06-14 | 2012-11-27 | Cipla Limited | Combination of azelastine and mometasone for nasal administration |
US8933060B2 (en) | 2002-06-14 | 2015-01-13 | Cipla Limited | Combination of azelastine and ciclesonide for nasal administration |
US8937057B2 (en) | 2002-06-14 | 2015-01-20 | Cipla Limited | Combination of azelastine and mometasone for nasal administration |
US8304405B2 (en) | 2002-06-14 | 2012-11-06 | Cipla Limited | Combination of azelastine and ciclesonide for nasal administration |
US8168620B2 (en) | 2002-06-14 | 2012-05-01 | Cipla Limited | Combination of azelastine and steroids |
US8163723B2 (en) | 2002-06-14 | 2012-04-24 | Cipla Limited | Combination of azelastine and steroids |
US9259428B2 (en) | 2002-06-14 | 2016-02-16 | Cipla Limited | Combination of azelastine and fluticasone for nasal administration |
US9901585B2 (en) | 2002-06-14 | 2018-02-27 | Cipla Limited | Combination of azelastine and fluticasone for nasal administration |
US7776846B2 (en) | 2003-06-19 | 2010-08-17 | Bodor Nicholas S | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids for topical or other local application |
US7419971B2 (en) | 2003-06-19 | 2008-09-02 | Bodor Nicholas S | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids for topical or other local application |
US7923441B2 (en) | 2003-06-19 | 2011-04-12 | Bodor Nicholas S | Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application |
US7560448B2 (en) | 2003-06-19 | 2009-07-14 | Bodor Nicholas S | Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application |
WO2005005451A1 (en) | 2003-07-11 | 2005-01-20 | Glaxo Group Limited | Specific glucocorticosteroid compound having anti- inflammatory activity |
JP4709751B2 (ja) * | 2003-07-11 | 2011-06-22 | グラクソ グループ リミテッド | 抗炎症活性を持つ特定のグルココルチコステロイド化合物 |
US7638508B2 (en) | 2003-07-11 | 2009-12-29 | Glaxo Group Limited | Glucocorticosteroid compound having anti-inflammatory activity |
AU2004255854B2 (en) * | 2003-07-11 | 2009-10-22 | Glaxo Group Limited | Specific glucocorticosteroid compound having anti- inflammatory activity |
US7288536B2 (en) | 2003-07-11 | 2007-10-30 | Glaxo Group Limited | Specific glucocorticosteroid compound having anti-inflammatory activity |
JP2009513533A (ja) * | 2003-07-11 | 2009-04-02 | グラクソ グループ リミテッド | 抗炎症活性を持つ特定のグルココルチコステロイド化合物 |
US7291609B2 (en) | 2003-07-11 | 2007-11-06 | Glaxo Group Limited | Specific glucocorticosteroid compound having anti-inflammatory activity |
US7579335B2 (en) | 2005-01-10 | 2009-08-25 | Glaxo Group Limited | Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
US7691811B2 (en) | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
US7687484B2 (en) | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
US8835410B2 (en) | 2011-05-10 | 2014-09-16 | Bodor Laboratories, Inc. | Treatment of eyelid dermatitis |
Also Published As
Publication number | Publication date |
---|---|
SE383522B (sv) | 1976-03-15 |
NO137321C (no) | 1978-02-08 |
IE36000L (en) | 1972-07-20 |
NL172511C (nl) | 1983-09-16 |
AU3811072A (en) | 1973-07-26 |
BE778285A (fr) | 1972-07-20 |
JPS5611720B1 (xx) | 1981-03-16 |
DE2202691A1 (de) | 1972-08-03 |
ES399057A1 (es) | 1974-11-01 |
CA1003820A (en) | 1977-01-18 |
NO137321B (no) | 1977-10-31 |
CH602786A5 (xx) | 1978-08-15 |
IL38589A (en) | 1976-06-30 |
NL7200818A (xx) | 1972-07-24 |
NL172511B (nl) | 1983-04-18 |
ZA72401B (en) | 1973-09-26 |
DK132894B (da) | 1976-02-23 |
FR2122539B1 (xx) | 1975-11-28 |
FR2122539A1 (xx) | 1972-09-01 |
HK34278A (en) | 1978-07-07 |
IL38589A0 (en) | 1972-03-28 |
IE36000B1 (en) | 1976-07-21 |
AU473868B2 (en) | 1976-07-08 |
DK132894C (da) | 1976-07-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1384372A (en) | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids | |
GB1438940A (en) | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids | |
DE3474025D1 (en) | Carboxylic acid esters of steroids | |
GB1490603A (en) | Glycerides with anti-inflammatory properties | |
GB1512955A (en) | Cyclopropane carboxylic esters | |
GB1369795A (en) | Process for preparing methacrylate esters of phenol derivatives | |
GB1368074A (en) | Substituted beta-lactams and their preparation | |
GB1352027A (en) | Process for the manufacture of pregnane compounds and process for the manufacture of sulphite esters | |
DE2967004D1 (en) | Mixed anhydride steroid intermediate and process for preparing steroid intermediates | |
GB1473574A (en) | Sitosterol esters | |
JPS5265263A (en) | Azetidinone compounds | |
GB1374342A (en) | Production of carboxylic acid glycidyl esters | |
GB1463850A (en) | 4-deoxy-4-oxoerythromycin b derivatives | |
IE37657L (en) | Prednisolone derivative. | |
GB2017099A (en) | beta -Lactam antibiotics preparation | |
JPS51131821A (en) | Process for preparation of gamma-halo-delta-unsaturated carboxylic acids | |
GB1479712A (en) | 7-amino-3-thiomethyl-cephem-4-carboxylic acid derivatives | |
GB1312532A (en) | Process for the esterification of 17-hydroxy steroids | |
GB1130869A (en) | -‡-methyl--‡-carboalkoxy--ß-phenyl-propionic acid derivatives | |
GB1507037A (en) | 2,6beta-difluoropregnenes | |
GB1223036A (en) | Succinimide derivatives | |
GB1324494A (en) | Process for producing indolylacetic acid derivatives | |
KR900007778A (ko) | 벤조일 말로네이트 유도체의 제조방법 | |
IT1039779B (it) | Processo di esterificazione | |
NL7508728A (en) | Esterifying fatty acids using tetraalkyl titanates - esp. useful for esters of conjugated unsatd. acids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |