GB1351261A - Preparation of vincamine alkaloids - Google Patents
Preparation of vincamine alkaloidsInfo
- Publication number
- GB1351261A GB1351261A GB2578671*A GB2578671A GB1351261A GB 1351261 A GB1351261 A GB 1351261A GB 2578671 A GB2578671 A GB 2578671A GB 1351261 A GB1351261 A GB 1351261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparation
- vincamine
- alkaloids
- afford compound
- vincamine alkaloids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical class C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 alkali metal methoxide Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7011406A FR2081593A1 (en) | 1970-03-31 | 1970-03-31 | Vincamine process |
| FR7032889A FR2104959A2 (en) | 1970-09-10 | 1970-09-10 | Vincamine process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1351261A true GB1351261A (en) | 1974-04-24 |
Family
ID=26215644
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2578671*A Expired GB1351261A (en) | 1970-03-31 | 1971-04-19 | Preparation of vincamine alkaloids |
| GB2578671*A Expired GB1351262A (en) | 1970-03-31 | 1971-04-19 | Quinolizine derivatives |
| GB2578671*A Expired GB1351263A (en) | 1970-03-31 | 1971-04-19 | Eburnane derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2578671*A Expired GB1351262A (en) | 1970-03-31 | 1971-04-19 | Quinolizine derivatives |
| GB2578671*A Expired GB1351263A (en) | 1970-03-31 | 1971-04-19 | Eburnane derivatives |
Country Status (16)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL153199B (nl) * | 1971-10-25 | 1977-05-16 | Omnium Chimique Sa | Werkwijze voor de bereiding van esters van vincaminezuur, alsmede werkwijze voor de bereiding van een geneesmiddel dat een dergelijke ester bevat en gevormd geneesmiddel dat aldus is verkregen. |
| CH578001A5 (enrdf_load_stackoverflow) * | 1972-04-14 | 1976-07-30 | Sandoz Ag | |
| FR2179620B1 (enrdf_load_stackoverflow) * | 1972-04-14 | 1975-12-26 | Roussel Uclaf | |
| US4033969A (en) * | 1972-06-19 | 1977-07-05 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vincamine derivatives |
| FR2259612B1 (enrdf_load_stackoverflow) * | 1974-01-31 | 1977-09-09 | Synthelabo | |
| CH625239A5 (enrdf_load_stackoverflow) * | 1974-08-09 | 1981-09-15 | Buskine Sa | |
| JPS536264U (enrdf_load_stackoverflow) * | 1976-06-30 | 1978-01-20 | ||
| HU174502B (hu) * | 1976-12-30 | 1980-01-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh oktagidro-indolo/2,3-a/-khinolizina |
| US4428877A (en) | 1978-07-12 | 1984-01-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Cis-10-bromo-E-homoeburnanes |
| US4315011A (en) * | 1978-07-12 | 1982-02-09 | Richter Gedeon Vegyeszeti Gyar Rt. | 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow |
| CH649295A5 (de) * | 1978-07-12 | 1985-05-15 | Richter Gedeon Vegyeszet | Optisch aktive oder razemische brom-e-homo-eburanderivate. |
| US4316028A (en) * | 1978-11-20 | 1982-02-16 | Sumitomo Chemical Company, Limited | Process for producing eburnane derivatives |
| AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
| HU179292B (en) * | 1978-12-01 | 1982-09-28 | Richter Gedeon Vegyeszet | Process for preparing ester derivatives of apovincaminic acid |
| HU180928B (en) * | 1979-08-06 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives |
| HU181496B (en) * | 1979-08-13 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for preparing 10-bromo-15-hydroxy-e-homo-eburnanes |
| JPS5689589U (enrdf_load_stackoverflow) * | 1979-12-13 | 1981-07-17 | ||
| JPS5693693U (enrdf_load_stackoverflow) * | 1979-12-14 | 1981-07-25 | ||
| HU185305B (en) * | 1981-08-23 | 1985-01-28 | Richter Gedeon Vegyeszet | Process for preparing vincine and apovincine |
| HU183234B (en) * | 1980-10-17 | 1984-04-28 | Richter Gedeon Vegyeszet | Process for the enantioselective synthesis of optically active cys-14-oxo-e-homo-eburnan |
| HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
| HU186891B (en) * | 1981-06-12 | 1985-10-28 | Richter Gedeon Vegyeszet | Process for producing esters of apovincaminic acid |
| HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
| JPS59258U (ja) * | 1982-06-24 | 1984-01-05 | 日本ピラ−工業株式会社 | 平板形電子管式表示装置 |
| HU187139B (en) * | 1982-06-30 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for preparing new eburnan derivatives |
| HU187733B (en) * | 1982-06-30 | 1986-02-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing apovincaminic acid derivatives |
| HU187140B (en) * | 1982-06-30 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for preparing new aburnan-oxima ethers |
| JPS6032240A (ja) * | 1983-07-30 | 1985-02-19 | Sony Corp | 螢光表示装置 |
| AU2003250483A1 (en) | 2002-08-19 | 2004-03-11 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN119112897A (zh) | 2019-01-18 | 2024-12-13 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
| CN111205288B (zh) * | 2020-02-19 | 2021-03-30 | 四川大学 | 一种(1S,12bS)内酰胺酯化合物的合成方法 |
-
1971
- 1971-03-22 US US00126929A patent/US3770724A/en not_active Expired - Lifetime
- 1971-03-23 IL IL36474A patent/IL36474A/xx unknown
- 1971-03-23 PL PL1971147087A patent/PL83152B1/pl unknown
- 1971-03-23 CH CH422071A patent/CH546777A/fr not_active IP Right Cessation
- 1971-03-25 HU HURO609A patent/HU163769B/hu unknown
- 1971-03-30 SU SU711633905A patent/SU505365A3/ru active
- 1971-03-30 CA CA109157A patent/CA937570A/en not_active Expired
- 1971-03-30 BE BE765006A patent/BE765006A/xx not_active IP Right Cessation
- 1971-03-31 DE DE2115718A patent/DE2115718C3/de not_active Expired
- 1971-03-31 NL NL7104275.A patent/NL158497B/xx not_active IP Right Cessation
- 1971-03-31 DK DK153171A patent/DK149345C/da not_active IP Right Cessation
- 1971-03-31 DE DE2167044A patent/DE2167044C2/de not_active Expired
- 1971-03-31 SE SE7104214A patent/SE386179B/xx unknown
- 1971-03-31 DE DE19712167043 patent/DE2167043A1/de not_active Ceased
- 1971-03-31 SE SE7405749A patent/SE390414B/xx not_active IP Right Cessation
- 1971-03-31 AT ATA2739/71A patent/AT309699B/de not_active IP Right Cessation
- 1971-03-31 JP JP46018828A patent/JPS5144960B1/ja active Pending
- 1971-04-19 GB GB2578671*A patent/GB1351261A/en not_active Expired
- 1971-04-19 GB GB2578671*A patent/GB1351262A/en not_active Expired
- 1971-04-19 GB GB2578671*A patent/GB1351263A/en not_active Expired
-
1975
- 1975-10-15 JP JP12333275A patent/JPS5337360B2/ja not_active Expired
- 1975-10-15 JP JP50123333A patent/JPS5227160B2/ja not_active Expired
-
1980
- 1980-02-28 IT IT8048032A patent/IT8048032A0/it unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |