GB1283804A - A process for the manufacture of amino acids and derivatives thereof - Google Patents
A process for the manufacture of amino acids and derivatives thereofInfo
- Publication number
- GB1283804A GB1283804A GB22808/70A GB2280870A GB1283804A GB 1283804 A GB1283804 A GB 1283804A GB 22808/70 A GB22808/70 A GB 22808/70A GB 2280870 A GB2280870 A GB 2280870A GB 1283804 A GB1283804 A GB 1283804A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- represents hydrogen
- lower alkyl
- hydroxy
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1283804 3,4 - Dihydroxyphenylalanine derivatives F HOFFMANN-LA ROCHE & CO AG 12 May 1970 [14 May 1969] 22808/70 Heading C2C Compounds of Formula I in which R 1 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino, n stands for 1, 2 or 3, R 2 represents hydrogen or lower alkyl, R 3 represents hydroxy or optionally mono- or di-lower alkyl-substituted amino, R 4 represents hydrogen, lower alkyl, lower alkanoyl or aroyl and R 5 represents hydrogen or lower alkyl, "lower" denoting groups containing up to 6 carbon atoms, and salts thereof, which process comprises subjecting a compound of the general Formula II wherein one of the substituents R 6 and R 7 is hydroxy and the other substituent is lower alkanoyl, aroyl or carboxy, or a salt of such a compound to an oxidative rearrangement and saponifying the carboxylic acid ester obtained and, in any desired sequence, hydrolysing the product obtained if desired, resolving a racemate obtained into its optically active forms, if desired, and converting a product obtained into a salt if desired. Pharmaceutical compositions in conventional forms and having hypotensive and anti- Parkison activity comprise a novel compound of Formula I above, i.e. one in which n is 1 and R 1 is halogen or C 1-6 alkyl provided that R 2 is alkyl when R 1 is in the 2-position and R 2 is alkyl when R 1 is alkyl, and a carrier or diluent. Reference has been directed by the Comptroller to Specification 1,023,204.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH735269A CH521313A (en) | 1969-05-14 | 1969-05-14 | Process for the preparation of phenylalamine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1283804A true GB1283804A (en) | 1972-08-02 |
Family
ID=4323785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB22808/70A Expired GB1283804A (en) | 1969-05-14 | 1970-05-12 | A process for the manufacture of amino acids and derivatives thereof |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS5220470B1 (en) |
AT (1) | AT300768B (en) |
BE (1) | BE750209A (en) |
CH (1) | CH521313A (en) |
ES (1) | ES379619A1 (en) |
FR (1) | FR2051524B1 (en) |
GB (1) | GB1283804A (en) |
IE (1) | IE34145B1 (en) |
IL (1) | IL34505A (en) |
NL (1) | NL144592B (en) |
NO (1) | NO127534B (en) |
RO (1) | RO58401A (en) |
SU (1) | SU376935A3 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE48715B1 (en) * | 1978-12-22 | 1985-05-01 | Elan Corp Plc | New galencial forms for administration of medicaments by oral route,with programmed release and processes for preparing same |
FR2452922A2 (en) * | 1979-04-02 | 1980-10-31 | Panoz Donald | Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression |
JPS5596436A (en) * | 1979-01-19 | 1980-07-22 | Nippon Hodo Co Ltd | Method of preserving soil sample |
JPS6033001U (en) * | 1983-08-12 | 1985-03-06 | 株式会社 長崎機器製作所 | Upper residual air removal device for flexible container containers |
JPS618501U (en) * | 1984-06-19 | 1986-01-18 | 雪印乳業株式会社 | Deaeration bag packaging equipment for powder, etc. |
-
1969
- 1969-05-14 CH CH735269A patent/CH521313A/en not_active IP Right Cessation
-
1970
- 1970-05-08 RO RO63301A patent/RO58401A/ro unknown
- 1970-05-10 IL IL34505A patent/IL34505A/en unknown
- 1970-05-11 IE IE609/70A patent/IE34145B1/en unknown
- 1970-05-11 BE BE750209D patent/BE750209A/en unknown
- 1970-05-11 NO NO01786/70A patent/NO127534B/no unknown
- 1970-05-12 NL NL707006842A patent/NL144592B/en not_active IP Right Cessation
- 1970-05-12 GB GB22808/70A patent/GB1283804A/en not_active Expired
- 1970-05-12 SU SU1443804A patent/SU376935A3/ru active
- 1970-05-13 ES ES379619A patent/ES379619A1/en not_active Expired
- 1970-05-13 AT AT430870A patent/AT300768B/en not_active IP Right Cessation
- 1970-05-13 FR FR7017384A patent/FR2051524B1/fr not_active Expired
- 1970-05-14 JP JP45040578A patent/JPS5220470B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2051524B1 (en) | 1974-03-22 |
DE2023461A1 (en) | 1970-11-19 |
AT300768B (en) | 1972-08-10 |
BE750209A (en) | 1970-11-12 |
NL144592B (en) | 1975-01-15 |
ES379619A1 (en) | 1973-01-16 |
DE2023461B2 (en) | 1977-06-08 |
NO127534B (en) | 1973-07-09 |
JPS5220470B1 (en) | 1977-06-03 |
IE34145L (en) | 1970-11-14 |
RO58401A (en) | 1975-09-15 |
IE34145B1 (en) | 1975-02-19 |
IL34505A0 (en) | 1970-07-19 |
FR2051524A1 (en) | 1971-04-09 |
CH521313A (en) | 1972-04-15 |
IL34505A (en) | 1974-10-22 |
SU376935A3 (en) | 1973-04-05 |
NL7006842A (en) | 1970-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |