GB1278368A - Hydroxy-2-piperidinyl carbinols - Google Patents

Hydroxy-2-piperidinyl carbinols

Info

Publication number
GB1278368A
GB1278368A GB47372/70A GB4737270A GB1278368A GB 1278368 A GB1278368 A GB 1278368A GB 47372/70 A GB47372/70 A GB 47372/70A GB 4737270 A GB4737270 A GB 4737270A GB 1278368 A GB1278368 A GB 1278368A
Authority
GB
United Kingdom
Prior art keywords
prepared
piperidinyl
reaction
chloroprotocatechualdehyde
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47372/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB1278368A publication Critical patent/GB1278368A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

1278368 Piperidinyl - carbinol derivatives SMITH KLINE & FRENCH LABORATORIES 6 Oct 1970 [8 Oct 1969] 47372/70 Heading C2C Novel compound I in which R 1 is H, CH 3 or Cl and R 2 -R 4 are H or OH, at least one being OH, and their salts are prepared by methods illustrated in the following reaction sequence. Intermediates isolated are the compounds shown in the reaction sequence above and 2-chloroprotocatechualdehyde, prepared by reaction of 2-chloro-isovanillin with BBr 3 ; and 2-chloro- 3,4 dibenzyloxy - benzaldehyde, prepared by reaction of 2-chloroprotocatechualdehyde with benzyl chloride. Pharmaceutical compositions with use as #- adrenergic stimulants comprise a compound I together with a suitable carrier or diluent.
GB47372/70A 1969-10-08 1970-10-06 Hydroxy-2-piperidinyl carbinols Expired GB1278368A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86486569A 1969-10-08 1969-10-08

Publications (1)

Publication Number Publication Date
GB1278368A true GB1278368A (en) 1972-06-21

Family

ID=25344244

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47372/70A Expired GB1278368A (en) 1969-10-08 1970-10-06 Hydroxy-2-piperidinyl carbinols

Country Status (10)

Country Link
JP (1) JPS4811101B1 (en)
BE (1) BE756973A (en)
CA (1) CA958718A (en)
DE (1) DE2047937A1 (en)
FR (1) FR2070113B1 (en)
GB (1) GB1278368A (en)
KE (1) KE2564A (en)
LU (1) LU61827A1 (en)
MY (1) MY7500242A (en)
ZA (1) ZA706324B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007102011A1 (en) * 2006-03-09 2007-09-13 Sosei R & D Ltd. The use of beta-aminoalcohols for the treatment of inflammatory disorders and pain

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA960676A (en) * 1970-05-21 1975-01-07 Smith Kline And French Canada Ltd. 3-sulfonamido-4-hydroxyphenyl-2-piperidinylcarbinols
ZA994264B (en) 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
US7232837B2 (en) 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE569836A (en) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007102011A1 (en) * 2006-03-09 2007-09-13 Sosei R & D Ltd. The use of beta-aminoalcohols for the treatment of inflammatory disorders and pain

Also Published As

Publication number Publication date
CA958718A (en) 1974-12-03
KE2564A (en) 1975-09-19
ZA706324B (en) 1971-04-28
DE2047937A1 (en) 1971-04-22
JPS4811101B1 (en) 1973-04-10
MY7500242A (en) 1975-12-31
FR2070113B1 (en) 1974-05-24
LU61827A1 (en) 1971-04-29
FR2070113A1 (en) 1971-09-10
BE756973A (en) 1971-04-02

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Legal Events

Date Code Title Description
PS Patent sealed
48S Specification amended (sect. 8/1949)
SPA Amended specification published
PE20 Patent expired after termination of 20 years