GB1331522A - Piperazinyl-quinazolone-4-derivatives process for producing them and medicines comprising them - Google Patents
Piperazinyl-quinazolone-4-derivatives process for producing them and medicines comprising themInfo
- Publication number
- GB1331522A GB1331522A GB1880371*[A GB1880371A GB1331522A GB 1331522 A GB1331522 A GB 1331522A GB 1880371 A GB1880371 A GB 1880371A GB 1331522 A GB1331522 A GB 1331522A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- hal
- reaction
- alkyl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- HVAIODZDHYPCPV-UHFFFAOYSA-N 2-amino-4,5-dimethoxy-n-methylbenzamide Chemical compound CNC(=O)C1=CC(OC)=C(OC)C=C1N HVAIODZDHYPCPV-UHFFFAOYSA-N 0.000 abstract 1
- LFQRQTYMRHCNTP-UHFFFAOYSA-N 4-piperazin-1-yl-1h-quinazolin-2-one Chemical class C12=CC=CC=C2NC(=O)N=C1N1CCNCC1 LFQRQTYMRHCNTP-UHFFFAOYSA-N 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- -1 CF 3 Chemical group 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702027645 DE2027645A1 (de) | 1970-06-05 | 1970-06-05 | Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1331522A true GB1331522A (en) | 1973-09-26 |
Family
ID=5773104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1880371*[A Expired GB1331522A (en) | 1970-06-05 | 1971-06-03 | Piperazinyl-quinazolone-4-derivatives process for producing them and medicines comprising them |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3984555A (cg-RX-API-DMAC10.html) |
| AT (3) | AT317899B (cg-RX-API-DMAC10.html) |
| BE (1) | BE768137A (cg-RX-API-DMAC10.html) |
| CA (1) | CA951319A (cg-RX-API-DMAC10.html) |
| CH (3) | CH557829A (cg-RX-API-DMAC10.html) |
| DE (1) | DE2027645A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2100726B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1331522A (cg-RX-API-DMAC10.html) |
| LU (1) | LU63267A1 (cg-RX-API-DMAC10.html) |
| NL (1) | NL7107695A (cg-RX-API-DMAC10.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002048117A1 (en) * | 2000-12-11 | 2002-06-20 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
| WO2003063874A1 (en) * | 2002-01-29 | 2003-08-07 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
| US6723727B1 (en) * | 1996-12-20 | 2004-04-20 | Hoechst Aktiengesellschaft | Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them |
| US5972929A (en) * | 1997-08-21 | 1999-10-26 | Shiseido Co., Ltd. | Quinazolinone derivative, hair growth promoter and external composition for skin using the same |
| EP1216243A1 (en) | 1999-10-01 | 2002-06-26 | Advanced Medicine, Inc. | Quinazolinones and analogues and their use as local anesthetics |
| ATE502941T1 (de) * | 2000-04-25 | 2011-04-15 | Icos Corp | Hemmer der menschlichen phosphatidyl-inositol-3- kinase delta |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| EP2116248A1 (en) | 2001-09-05 | 2009-11-11 | Minerva Biotechnologies Corporation | Compositions and Methods of Treatment of Cancer |
| CA2459584A1 (en) * | 2001-09-05 | 2003-03-13 | Cynthia C. Bamdad | Compositions and use thereof in the treatment of cancer |
| JP2005511581A (ja) * | 2001-11-07 | 2005-04-28 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| WO2004018058A2 (en) * | 2002-08-21 | 2004-03-04 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US20060052345A1 (en) * | 2002-11-04 | 2006-03-09 | Nps Pharmaceuticals, Inc. | Quinazolinone compounds as calcilytics |
| ATE440825T1 (de) * | 2003-06-06 | 2009-09-15 | Vertex Pharma | Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern |
| US20050043239A1 (en) * | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
| WO2005016349A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Methods of inhibiting leukocyte accumulation |
| PT2612862T (pt) | 2004-05-13 | 2016-12-15 | Icos Corp | Quinazolinonas como inibidores de fosfatidilinositol 3-quinase delta humana |
| WO2005117889A1 (en) * | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic |
| EP1885356A2 (en) * | 2005-02-17 | 2008-02-13 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| WO2007110868A2 (en) * | 2006-03-28 | 2007-10-04 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| WO2010057048A1 (en) | 2008-11-13 | 2010-05-20 | Calistoga Pharmaceuticals Inc. | Therapies for hematologic malignancies |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| MX2011009955A (es) | 2009-03-24 | 2011-11-18 | Gilead Calistoga Llc | Atropisomeros de derivados de 2-purinil-3-tolil-quinazolinona y metodos de uso. |
| AP2011005956A0 (en) * | 2009-04-20 | 2011-10-31 | Gilead Calistoga Llc | Methods of treatment for solid tumors. |
| AU2010276160A1 (en) | 2009-07-21 | 2012-02-09 | Gilead Calistoga Llc | Treatment of liver disorders with PI3K inhibitors |
| BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
| US9353067B2 (en) | 2011-04-10 | 2016-05-31 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| MD20140100A2 (ro) | 2012-03-05 | 2015-01-31 | Gilead Calistoga Llc | Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei |
| AU2013288265B2 (en) | 2012-07-09 | 2017-04-06 | Lupin Limited | Tetrahydroquinazolinone derivatives as PARP inhibitors |
| US9567337B2 (en) | 2013-12-20 | 2017-02-14 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| JP2017500319A (ja) | 2013-12-20 | 2017-01-05 | ギリアード カリストガ エルエルシー | （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態 |
| WO2015191726A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1249281B (cg-RX-API-DMAC10.html) * | 1963-05-18 |
-
1970
- 1970-06-05 DE DE19702027645 patent/DE2027645A1/de active Pending
-
1971
- 1971-05-28 US US05/148,100 patent/US3984555A/en not_active Expired - Lifetime
- 1971-06-01 AT AT244273A patent/AT317899B/de not_active IP Right Cessation
- 1971-06-01 AT AT470571A patent/AT318615B/de not_active IP Right Cessation
- 1971-06-01 AT AT244173A patent/AT318628B/de not_active IP Right Cessation
- 1971-06-02 CH CH802071A patent/CH557829A/xx not_active IP Right Cessation
- 1971-06-02 CH CH450074A patent/CH558374A/xx not_active IP Right Cessation
- 1971-06-02 CH CH450174A patent/CH569732A5/xx not_active IP Right Cessation
- 1971-06-02 LU LU63267D patent/LU63267A1/xx unknown
- 1971-06-03 CA CA114,709,A patent/CA951319A/en not_active Expired
- 1971-06-03 GB GB1880371*[A patent/GB1331522A/en not_active Expired
- 1971-06-04 FR FR7120368A patent/FR2100726B1/fr not_active Expired
- 1971-06-04 BE BE768137A patent/BE768137A/xx unknown
- 1971-06-04 NL NL7107695A patent/NL7107695A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002048117A1 (en) * | 2000-12-11 | 2002-06-20 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
| WO2003063874A1 (en) * | 2002-01-29 | 2003-08-07 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| AT317899B (de) | 1974-09-25 |
| FR2100726B1 (cg-RX-API-DMAC10.html) | 1975-10-10 |
| US3984555A (en) | 1976-10-05 |
| CH569732A5 (cg-RX-API-DMAC10.html) | 1975-11-28 |
| CA951319A (en) | 1974-07-16 |
| CH558374A (de) | 1975-01-31 |
| CH557829A (de) | 1975-01-15 |
| NL7107695A (cg-RX-API-DMAC10.html) | 1971-12-07 |
| FR2100726A1 (cg-RX-API-DMAC10.html) | 1972-03-24 |
| BE768137A (fr) | 1971-12-06 |
| DE2027645A1 (de) | 1971-12-09 |
| AT318628B (de) | 1974-11-11 |
| AT318615B (de) | 1974-11-11 |
| LU63267A1 (cg-RX-API-DMAC10.html) | 1972-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |