GB1512101A - Piperazinopyrimidines process for their preparation and use - Google Patents

Piperazinopyrimidines process for their preparation and use

Info

Publication number
GB1512101A
GB1512101A GB33132/75A GB3313275A GB1512101A GB 1512101 A GB1512101 A GB 1512101A GB 33132/75 A GB33132/75 A GB 33132/75A GB 3313275 A GB3313275 A GB 3313275A GB 1512101 A GB1512101 A GB 1512101A
Authority
GB
United Kingdom
Prior art keywords
group
carbon atoms
aug
alkyl group
piperazinopyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33132/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Original Assignee
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Produits Chimiques Ugine Kuhlmann, Ugine Kuhlmann SA filed Critical Produits Chimiques Ugine Kuhlmann
Publication of GB1512101A publication Critical patent/GB1512101A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1512101 Piperazino-pyrimidines PRODUITS CHIMIQUES UGINE KUHLMANN 8 Aug 1975 [9 Aug 1974] 33132/75 Addition to 1434544 Heading C2C Novel compounds (II) (including salts thereof) in which Z represents an alkyl group having 1 to 4 carbon atoms, R 1 represents a hydrogen atom or a methyl or ethyl group, and R 2 represents a linear alkyl group having 3 to 6 carbon atoms, an allyl, hydroxyethyl or cycloalkyl group having 3 to 8 carbon atoms, a benzyl or p-methoxyphenyl group and the -NR 1 R 2 residue may represent a morpholino group, are made by condensing the appropriate amines with 2,4,6-trichloro-5-methylthio-pyrimidine in a two-step process. Pharmaceutical prearations having antiemetic, neuroleptic, spasmolytic, analgesic and antiserotonine actions contain (II) as active ingredient.
GB33132/75A 1974-08-09 1975-08-08 Piperazinopyrimidines process for their preparation and use Expired GB1512101A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7427671A FR2281117A2 (en) 1974-08-09 1974-08-09 NEW PIPERAZINO-PYRIMIDINES FOR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
GB1512101A true GB1512101A (en) 1978-05-24

Family

ID=9142279

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33132/75A Expired GB1512101A (en) 1974-08-09 1975-08-08 Piperazinopyrimidines process for their preparation and use

Country Status (13)

Country Link
JP (2) JPS51125089A (en)
AR (1) AR205579A1 (en)
BE (1) BE832277R (en)
CA (1) CA1036598A (en)
CH (1) CH609692A5 (en)
DE (1) DE2534963A1 (en)
ES (1) ES440153A2 (en)
FR (1) FR2281117A2 (en)
GB (1) GB1512101A (en)
LU (1) LU73175A1 (en)
NL (1) NL7509184A (en)
NO (1) NO752586L (en)
ZA (1) ZA755118B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
WO2005003099A2 (en) * 2003-07-02 2005-01-13 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
US7880008B2 (en) 2005-05-31 2011-02-01 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2417507A2 (en) * 1977-07-28 1979-09-14 Ugine Kuhlmann DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES
FR2503162A1 (en) * 1981-04-07 1982-10-08 Pharmindustrie NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS
JPS5973573A (en) * 1982-09-09 1984-04-25 ワ−ナ−−ランバ−ト・コンパニ− Diaminopyrimidine compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2119234A5 (en) * 1970-12-24 1972-08-04 Ugine Kuhlmann 5-alkylthio amino halopyrimidines - fungicides herbicides insecticides and bactericides
FR2173746B1 (en) * 1972-03-01 1975-04-25 Ugine Kuhlmann

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US6995159B2 (en) 2001-06-21 2006-02-07 Pfizer Inc. 5-HT receptor ligands and uses thereof
WO2005003099A2 (en) * 2003-07-02 2005-01-13 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
WO2005003099A3 (en) * 2003-07-02 2005-05-12 Vertex Pharma Pyrimidines useful as modulators of voltage-gated ion channels
US7816529B2 (en) 2003-07-02 2010-10-19 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
US8324220B2 (en) 2003-07-02 2012-12-04 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
US7880008B2 (en) 2005-05-31 2011-02-01 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels
US8329702B2 (en) 2005-05-31 2012-12-11 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels

Also Published As

Publication number Publication date
BE832277R (en) 1976-02-09
ES440153A2 (en) 1977-07-01
DE2534963A1 (en) 1976-02-19
CH609692A5 (en) 1979-03-15
ZA755118B (en) 1976-07-28
JPS5946943B2 (en) 1984-11-15
AR205579A1 (en) 1976-05-14
NO752586L (en) 1976-02-10
FR2281117B2 (en) 1978-07-28
CA1036598A (en) 1978-08-15
JPS58150571A (en) 1983-09-07
FR2281117A2 (en) 1976-03-05
JPS51125089A (en) 1976-11-01
NL7509184A (en) 1976-02-11
LU73175A1 (en) 1976-03-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee