ES437790A1 - Therapeutic compositions containing methylamine derivatives or their salts - Google Patents

Therapeutic compositions containing methylamine derivatives or their salts

Info

Publication number
ES437790A1
ES437790A1 ES437790A ES437790A ES437790A1 ES 437790 A1 ES437790 A1 ES 437790A1 ES 437790 A ES437790 A ES 437790A ES 437790 A ES437790 A ES 437790A ES 437790 A1 ES437790 A1 ES 437790A1
Authority
ES
Spain
Prior art keywords
pharmaceutically acceptable
acid addition
reacted
methylamine
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES437790A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Publication of ES437790A1 publication Critical patent/ES437790A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids

Abstract

Procedure for preparing pharmaceutical and veterinary compositions, useful in the treatment of Parkinson's disease and for correcting extrapyramidal disturbances caused by neuroleptics, characterized in that in an initial step, an isocyanate or an N-formylamine of the general formula is reacted: ** (See formula) ** wherein R1, R2 and R3 each represent a hydrogen atom or a straight-chain or branched alkyl, alkenyl or alkynyl radical containing 1 to 6 carbon atoms, and A is the group N = C = OoNH-C -H, R1, R2 and R3 being such that the compound of formula II has 5 to 13 carbon atoms, in a suitable medium, with a pharmaceutically acceptable strong acid, to form the corresponding acid addition salt of the methylamine derivative general formula: ** (See formula) ** wherein R1, R2 and R3 are defined as above, which, if desired, can be reacted with a base to obtain the methylamine derivative in the form of the free base, which can then be reacted with an organic acid or inorganic to give another pharmaceutically acceptable acid addition salt of the methylamine derivative; and in a second stage, the thus obtained methylamine derivative is associated, either in the form of the free base or in the form of a pharmaceutically acceptable acid addition salt, with a pharmaceutical carrier or excipient therefor and, if desired, with other methylamine derivatives or their pharmaceutically acceptable acid addition salts. (Machine-translation by Google Translate, not legally binding)
ES437790A 1974-05-20 1974-05-20 Therapeutic compositions containing methylamine derivatives or their salts Expired ES437790A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE144519A BE815273A (en) 1974-05-20 1974-05-20 METHYLAMINE ACTIVE DERIVATIVES

Publications (1)

Publication Number Publication Date
ES437790A1 true ES437790A1 (en) 1977-05-16

Family

ID=3842664

Family Applications (1)

Application Number Title Priority Date Filing Date
ES437790A Expired ES437790A1 (en) 1974-05-20 1974-05-20 Therapeutic compositions containing methylamine derivatives or their salts

Country Status (22)

Country Link
JP (1) JPS569498B2 (en)
AR (1) AR208548A1 (en)
AT (1) AT341488B (en)
BE (1) BE815273A (en)
CA (1) CA1048549A (en)
CH (1) CH605606A5 (en)
DE (1) DE2522218C3 (en)
DK (1) DK145779C (en)
ES (1) ES437790A1 (en)
FI (1) FI61182C (en)
FR (1) FR2271811B1 (en)
GB (2) GB1467739A (en)
HU (1) HU173890B (en)
IE (1) IE41032B1 (en)
IT (1) IT1049427B (en)
NL (1) NL172120C (en)
NO (1) NO139733C (en)
OA (1) OA05004A (en)
SE (1) SE434262B (en)
SU (1) SU1292666A3 (en)
YU (1) YU39318B (en)
ZA (1) ZA752863B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201725A (en) * 1974-05-20 1980-05-06 Labaz Secondary amines
GR61148B (en) * 1976-06-03 1978-09-27 Labaz Preparation process of active methylamine derivatives
JPS5427369A (en) * 1977-08-01 1979-03-01 Hitachi Ltd Pattern formation method
FR2470758A1 (en) 1979-12-07 1981-06-12 Sanofi Sa METHOD FOR FIXING ALKYL GROUPS ON A CARBONIC CHAIN CARRYING A FUNCTIONAL GROUP
MXPA02001095A (en) * 1999-07-30 2002-08-20 Vertex Pharma Acyclic and cyclic amine derivatives.
CN114235991A (en) * 2021-11-27 2022-03-25 山东省烟台市农业科学研究院 High performance liquid chromatography for determining sec-butylamine content

Also Published As

Publication number Publication date
ZA752863B (en) 1976-04-28
SE7505606L (en) 1975-11-21
HU173890B (en) 1979-09-28
JPS569498B2 (en) 1981-03-02
SE434262B (en) 1984-07-16
DE2522218A1 (en) 1975-12-04
DK216575A (en) 1975-11-21
CH605606A5 (en) 1978-09-29
NL172120B (en) 1983-02-16
GB1467740A (en) 1977-03-23
JPS514108A (en) 1976-01-14
FI751468A (en) 1975-11-21
NO139733B (en) 1979-01-22
SU1292666A3 (en) 1987-02-23
YU39318B (en) 1984-10-31
BE815273A (en) 1974-11-20
IE41032B1 (en) 1979-10-10
AR208548A1 (en) 1977-02-15
AT341488B (en) 1978-02-10
FI61182C (en) 1982-06-10
GB1467739A (en) 1977-03-23
YU122675A (en) 1982-02-28
FR2271811A1 (en) 1975-12-19
FI61182B (en) 1982-02-26
DE2522218B2 (en) 1980-07-10
ATA371575A (en) 1977-06-15
NO139733C (en) 1979-05-02
AU8102175A (en) 1976-11-11
DK145779B (en) 1983-02-28
CA1048549A (en) 1979-02-13
DE2522218C3 (en) 1981-04-02
NO751771L (en) 1975-11-21
NL7505853A (en) 1975-11-24
IT1049427B (en) 1981-01-20
OA05004A (en) 1980-12-31
IE41032L (en) 1975-10-20
DK145779C (en) 1983-08-22
NL172120C (en) 1983-07-18
FR2271811B1 (en) 1978-08-04

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