GB1182007A - Haloaryloxyacetic Acid Esters and Amides - Google Patents

Haloaryloxyacetic Acid Esters and Amides

Info

Publication number
GB1182007A
GB1182007A GB44020/67A GB4402067A GB1182007A GB 1182007 A GB1182007 A GB 1182007A GB 44020/67 A GB44020/67 A GB 44020/67A GB 4402067 A GB4402067 A GB 4402067A GB 1182007 A GB1182007 A GB 1182007A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
alkyl
amino
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44020/67A
Other languages
English (en)
Inventor
William Alfred Bolhofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1182007A publication Critical patent/GB1182007A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/50—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB44020/67A 1966-10-03 1967-09-27 Haloaryloxyacetic Acid Esters and Amides Expired GB1182007A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58393766A 1966-10-03 1966-10-03

Publications (1)

Publication Number Publication Date
GB1182007A true GB1182007A (en) 1970-02-25

Family

ID=24335223

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44020/67A Expired GB1182007A (en) 1966-10-03 1967-09-27 Haloaryloxyacetic Acid Esters and Amides

Country Status (19)

Country Link
US (1) US3517050A (enExample)
AT (2) AT279590B (enExample)
BE (1) BE704574A (enExample)
BR (1) BR6793319D0 (enExample)
CH (1) CH512422A (enExample)
CS (1) CS170496B2 (enExample)
CY (1) CY650A (enExample)
DE (1) DE1643460A1 (enExample)
DK (1) DK120955B (enExample)
ES (1) ES345582A1 (enExample)
FI (1) FI48064C (enExample)
FR (2) FR1573841A (enExample)
GB (1) GB1182007A (enExample)
GR (1) GR34667B (enExample)
MY (1) MY7300079A (enExample)
NL (1) NL149484B (enExample)
NO (1) NO121787B (enExample)
SE (1) SE332182B (enExample)
YU (1) YU32921B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2281762C2 (ru) * 1999-06-04 2006-08-20 Метаболекс, Инк. Использование производных (3-тригалометилфенокси)-(4-галофенил) уксусной кислоты для лечения резистентности к инсулину, диабета ii типа, гиперлипидемии и гиперурикемии

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923855A (en) * 1972-07-13 1975-12-02 Merck & Co Inc 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
DK115374A (enExample) 1974-03-04 1975-11-03 Byk Gulden Lomberg Chem Fab
IL48707A0 (en) * 1974-12-30 1976-02-29 Synthelabo Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
FR2424247A2 (fr) * 1978-04-27 1979-11-23 Science Union & Cie Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6624194B1 (en) * 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
EP1366012A4 (en) * 2001-02-09 2005-11-02 Merck & Co Inc 2-ARYLOXY-2-ARYLALKANIC ACIDS AGAINST DIABETES AND FAILURE CHANGES
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
CN100525757C (zh) * 2003-06-20 2009-08-12 麦它波莱克斯股份有限公司 α-(苯氧基)苯乙酸衍生物的拆分
MXPA05013981A (es) * 2003-06-20 2006-03-02 Metabolex Inc Resolucion de derivados de acido a- (fenoxi) fenilacetico.
USD492579S1 (en) 2003-10-15 2004-07-06 The Gates Corporation Pulley
CA2555814A1 (en) 2004-02-18 2005-09-01 Metabolex, Inc. Alpha-(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
WO2005115384A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
US8288438B2 (en) 2005-03-21 2012-10-16 Metabolex, Inc. Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
US7432394B2 (en) * 2005-09-23 2008-10-07 Metabolex, Inc. Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
JP2015521184A (ja) * 2012-05-10 2015-07-27 セリックスビオ プライヴェート リミテッド メタボリック症候群の治療のための組成物と治療法
NZ711096A (en) * 2013-01-18 2016-10-28 Cymabay Therapeutics Inc Dcc mediated coupling for halofenate manufacture

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES251290A1 (es) * 1958-08-21 1960-04-01 Parke Davis & Co Un procedimiento para la producciën de alcohilaminas arilsustituidas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2281762C2 (ru) * 1999-06-04 2006-08-20 Метаболекс, Инк. Использование производных (3-тригалометилфенокси)-(4-галофенил) уксусной кислоты для лечения резистентности к инсулину, диабета ii типа, гиперлипидемии и гиперурикемии

Also Published As

Publication number Publication date
YU185167A (en) 1975-06-30
YU32921B (en) 1975-12-31
CH512422A (de) 1971-09-15
DE1643460A1 (de) 1971-01-28
GR34667B (el) 1968-06-05
FR8372M (enExample) 1971-02-22
FI48064C (fi) 1974-06-10
NO121787B (enExample) 1971-04-13
AT282617B (de) 1970-07-10
MY7300079A (en) 1973-12-31
FR1573841A (enExample) 1969-07-11
NL149484B (nl) 1976-05-17
NL6712584A (enExample) 1968-04-04
FI48064B (enExample) 1974-02-28
SE332182B (enExample) 1971-02-01
CS170496B2 (enExample) 1976-08-27
ES345582A1 (es) 1970-02-01
US3517050A (en) 1970-06-23
BE704574A (enExample) 1968-04-02
BR6793319D0 (pt) 1973-05-24
AT279590B (de) 1970-03-10
DK120955B (da) 1971-08-09
CY650A (en) 1972-07-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee