GB1180712A - Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof - Google Patents

Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof

Info

Publication number
GB1180712A
GB1180712A GB22420/68A GB2242068A GB1180712A GB 1180712 A GB1180712 A GB 1180712A GB 22420/68 A GB22420/68 A GB 22420/68A GB 2242068 A GB2242068 A GB 2242068A GB 1180712 A GB1180712 A GB 1180712A
Authority
GB
United Kingdom
Prior art keywords
pipecoloxylidide
butyl
levo
tartrate
dextro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22420/68A
Other languages
English (en)
Inventor
Froilan Pindaro Luduena
Benjamin Franklin Tullar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB1180712A publication Critical patent/GB1180712A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB22420/68A 1967-05-18 1968-05-10 Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof Expired GB1180712A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63927767A 1967-05-18 1967-05-18

Publications (1)

Publication Number Publication Date
GB1180712A true GB1180712A (en) 1970-02-11

Family

ID=24563449

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22420/68A Expired GB1180712A (en) 1967-05-18 1968-05-10 Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof

Country Status (13)

Country Link
AT (2) AT286298B (fi)
BE (1) BE715188A (fi)
CH (1) CH498834A (fi)
DE (1) DE1770408C3 (fi)
DK (1) DK129234B (fi)
ES (1) ES354352A1 (fi)
FI (1) FI50333C (fi)
FR (2) FR1583872A (fi)
GB (1) GB1180712A (fi)
IL (1) IL29958A (fi)
NL (1) NL6806995A (fi)
NO (1) NO124540B (fi)
SE (1) SE341404B (fi)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036606A1 (en) * 1995-05-16 1996-11-21 Astra Aktiebolag (Publ) New process for the preparation of ropivacaine hydrochloride monohydrate
US5994548A (en) * 1994-10-25 1999-11-30 Darwin Discovery Ltd. Crystallisation of levibupivacaine and analogues thereof
KR100844336B1 (ko) * 2007-01-16 2008-07-07 하나제약 주식회사 레보부피바카인 및 이의 염산염의 신규한 제조방법
WO2014009964A1 (en) * 2012-07-11 2014-01-16 Neon Laboratories Limited Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide
CN105315196A (zh) * 2015-11-28 2016-02-10 山东齐都药业有限公司 一种高纯度盐酸左布比卡因精制方法
CN109896992A (zh) * 2017-12-08 2019-06-18 武汉软件工程职业学院 制备离子液体的方法及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151110B1 (en) * 1983-08-01 1989-03-01 Astra Läkemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994548A (en) * 1994-10-25 1999-11-30 Darwin Discovery Ltd. Crystallisation of levibupivacaine and analogues thereof
WO1996036606A1 (en) * 1995-05-16 1996-11-21 Astra Aktiebolag (Publ) New process for the preparation of ropivacaine hydrochloride monohydrate
US5959112A (en) * 1995-05-16 1999-09-28 Astra Aktiebolag Process for the preparation of ropivacaine hydrochloride monohydrate
CN1121388C (zh) * 1995-05-16 2003-09-17 阿斯特拉公司 制备罗哌卡因盐酸盐—水合物的新方法
KR100844336B1 (ko) * 2007-01-16 2008-07-07 하나제약 주식회사 레보부피바카인 및 이의 염산염의 신규한 제조방법
WO2014009964A1 (en) * 2012-07-11 2014-01-16 Neon Laboratories Limited Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide
CN105315196A (zh) * 2015-11-28 2016-02-10 山东齐都药业有限公司 一种高纯度盐酸左布比卡因精制方法
CN109896992A (zh) * 2017-12-08 2019-06-18 武汉软件工程职业学院 制备离子液体的方法及其应用

Also Published As

Publication number Publication date
ES354352A1 (es) 1969-11-01
DE1770408C3 (de) 1974-11-07
DE1770408B2 (fi) 1974-04-11
FI50333B (fi) 1975-10-31
NL6806995A (fi) 1968-11-19
DK129234B (da) 1974-09-16
BE715188A (fi) 1968-09-30
IL29958A (en) 1971-04-28
CH498834A (de) 1970-11-15
AT286298B (de) 1970-12-10
DE1770408A1 (de) 1971-10-21
FI50333C (fi) 1976-02-10
AT284843B (de) 1970-09-25
SE341404B (fi) 1971-12-27
NO124540B (fi) 1972-05-02
FR1583872A (fi) 1969-12-05
DK129234C (fi) 1975-02-03
IL29958A0 (en) 1968-07-25
FR8160M (fi) 1970-08-24

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