GB1121722A - New carboxylic acid derivatives - Google Patents

New carboxylic acid derivatives

Info

Publication number
GB1121722A
GB1121722A GB14264/66A GB1426466A GB1121722A GB 1121722 A GB1121722 A GB 1121722A GB 14264/66 A GB14264/66 A GB 14264/66A GB 1426466 A GB1426466 A GB 1426466A GB 1121722 A GB1121722 A GB 1121722A
Authority
GB
United Kingdom
Prior art keywords
formula
amide
radical
carboxylic acid
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14264/66A
Other languages
English (en)
Inventor
Thomas Leigh
Jeffrey Meyrick Thorp
Wilson Shaw Waring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB14264/66A priority Critical patent/GB1121722A/en
Priority to US623230A priority patent/US3652646A/en
Priority to DE1593907A priority patent/DE1593907C2/de
Priority to DE19671793705 priority patent/DE1793705A1/de
Priority to IL27637A priority patent/IL27637A/xx
Priority to CA986112A priority patent/CA926399A/en
Priority to AT281567A priority patent/AT271457B/de
Priority to NO167518A priority patent/NO120479B/no
Priority to JP42020551A priority patent/JPS4916416B1/ja
Priority to BE696466D priority patent/BE696466A/xx
Priority to CH453467A priority patent/CH493455A/de
Priority to CH1861269A priority patent/CH505775A/de
Priority to DK187167AA priority patent/DK117827B/da
Priority to NL6704659A priority patent/NL6704659A/xx
Priority to FR101112A priority patent/FR1524380A/fr
Priority to ES338692A priority patent/ES338692A1/es
Priority to CH790970A priority patent/CH495334A/de
Priority to ES340020A priority patent/ES340020A1/es
Priority to FR112666A priority patent/FR6512M/fr
Publication of GB1121722A publication Critical patent/GB1121722A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
    • Y10S516/06—Protein or carboxylic compound containing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cable Accessories (AREA)
GB14264/66A 1966-03-31 1966-03-31 New carboxylic acid derivatives Expired GB1121722A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB14264/66A GB1121722A (en) 1966-03-31 1966-03-31 New carboxylic acid derivatives
US623230A US3652646A (en) 1966-03-31 1967-03-15 Carboxylic acid derivatives
DE1593907A DE1593907C2 (de) 1966-03-31 1967-03-17 alpha eckige Klammer auf 4-(p-subst.Phenyl>phenoxy eckige Klammer zu -carbonsäuren, deren Derivate sowie diese Verbindungen enthaltende Arzneimittel
DE19671793705 DE1793705A1 (de) 1966-03-31 1967-03-17 Carbonsaeurederivate und Verfahren zu deren Herstellung
IL27637A IL27637A (en) 1966-03-31 1967-03-19 Phenylphenoxy(and phenylphenylthio)-alkanoic acid derivatives
CA986112A CA926399A (en) 1966-03-31 1967-03-23 4(phenyl phenoxy) acetic acid derivatives
AT281567A AT271457B (de) 1966-03-31 1967-03-23 Verfahren zur Herstellung von neuen Biphenylyloxy-(bzw. -thio-, -sulfinyl- oder -sulfonyl)-alkansäuren und deren Estern bzw. Amiden oder Salzen
NO167518A NO120479B (enExample) 1966-03-31 1967-03-30
JP42020551A JPS4916416B1 (enExample) 1966-03-31 1967-03-31
BE696466D BE696466A (enExample) 1966-03-31 1967-03-31
CH453467A CH493455A (de) 1966-03-31 1967-03-31 Verfahren zur Herstellung von Carbonsäuren und deren Estern, Amiden und Salzen
CH1861269A CH505775A (de) 1966-03-31 1967-03-31 Verfahren zur Herstellung von Carbonsäuren
DK187167AA DK117827B (da) 1966-03-31 1967-03-31 Analogifremgangsmåde til fremstilling af terapeutisk virksomme carboxylsyrederivater eller estere, amider eller salte deraf.
NL6704659A NL6704659A (enExample) 1966-03-31 1967-03-31
FR101112A FR1524380A (fr) 1966-03-31 1967-03-31 Nouveaux dérivés d'acides carboxyliques
ES338692A ES338692A1 (es) 1966-03-31 1967-03-31 Procedimiento para la obtencion de derivados de acido car- boxilico.
CH790970A CH495334A (de) 1966-03-31 1967-03-31 Verfahren zur Herstellung von Carbonsäureamiden
ES340020A ES340020A1 (es) 1966-03-31 1967-04-29 Procedimiento para la obtencion de derivados de acido car- boxilico.
FR112666A FR6512M (enExample) 1966-03-31 1967-06-30

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB14264/66A GB1121722A (en) 1966-03-31 1966-03-31 New carboxylic acid derivatives
GB1426566 1966-03-31

Publications (1)

Publication Number Publication Date
GB1121722A true GB1121722A (en) 1968-07-31

Family

ID=26250426

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14264/66A Expired GB1121722A (en) 1966-03-31 1966-03-31 New carboxylic acid derivatives

Country Status (13)

Country Link
US (1) US3652646A (enExample)
JP (1) JPS4916416B1 (enExample)
BE (1) BE696466A (enExample)
CA (1) CA926399A (enExample)
CH (1) CH493455A (enExample)
DE (2) DE1793705A1 (enExample)
DK (1) DK117827B (enExample)
ES (2) ES338692A1 (enExample)
FR (1) FR6512M (enExample)
GB (1) GB1121722A (enExample)
IL (1) IL27637A (enExample)
NL (1) NL6704659A (enExample)
NO (1) NO120479B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2060072A1 (enExample) * 1969-08-01 1971-06-11 Sumitomo Chemical Co
US4191776A (en) * 1974-05-20 1980-03-04 Boehringer Ingelheim Gmbh Biphenyl derivatives
FR2505818A1 (fr) * 1981-05-18 1982-11-19 Upjohn Co Procede de production d'un biphenyle substitue
EP0080010A1 (en) * 1981-11-24 1983-06-01 AUSONIA FARMACEUTICI S.r.l. Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
EP0080011A1 (en) * 1981-11-24 1983-06-01 AUSONIA FARMACEUTICI S.r.l. Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
WO1999020604A1 (de) * 1997-10-22 1999-04-29 Bayer Aktiengesellschaft S-(4-biphenyl)-thioschwefelsäuren und ihre salze, verfahren zu deren herstellung und die herstellung von 4-mercaptobiphenylen

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52570C (fi) * 1969-04-16 1977-10-10 Sumitomo Chemical Co Menetelmä veren kolesteroli- tai lipoidipitoisuutta alentavien fenoxia lifaattisten karboksyylihappoyhdisteiden ja -esteriyhdisteiden valmist amiseksi.
US3931173A (en) * 1971-07-22 1976-01-06 Richardson-Merrell Inc. Dioxocin carboxamide derivatives
AR206596A1 (es) * 1972-08-29 1976-08-06 Sterling Drug Inc Procedimiento para preparar compuestos de acidos p-(dihalociclopropil)-fenoxialcanoicos
GB1422679A (en) * 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
DE2342118C2 (de) * 1973-08-21 1982-09-23 Merck Patent Gmbh, 6100 Darmstadt Phenoxypropionsäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
NL7416412A (nl) * 1973-12-27 1975-07-01 Siegfried Ag Werkwijze ter bereiding van nieuwe cholesterol- gende verbindingen.
US4012523A (en) * 1974-01-24 1977-03-15 The Dow Chemical Company Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-(thio or sulfonyl) alkanoic acids and derivatives
US4067998A (en) * 1974-02-11 1978-01-10 The Dow Chemical Company 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
US4042711A (en) * 1975-01-09 1977-08-16 Boehringer Ingelheim Gmbh Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their use as antihyperlipidemics
JPS5195049A (en) * 1975-02-12 1976-08-20 * **********so*****no***tsu*****************************************ni*no
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
US4062975A (en) * 1976-03-29 1977-12-13 The Dow Chemical Company Amino substituted arylthio-alkanoic acids having hypolipidemic activity
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4558071A (en) * 1979-08-15 1985-12-10 Merck & Co., Inc. Phenyl, trihalomethyl or heteroaryl sulfoxides having a latent allyl group bound to sulfur as enzyme inhibitors
US4388326A (en) * 1979-08-15 1983-06-14 Merck & Co., Inc. Phenyl hydroxypropyl sulfoxide enzyme inhibitors
US4342758A (en) * 1979-08-15 1982-08-03 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US4388475A (en) * 1979-08-15 1983-06-14 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US4332813A (en) * 1979-08-15 1982-06-01 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
IT1141655B (it) * 1980-02-12 1986-10-08 Schiapparelli Spa Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica
US4400395A (en) * 1980-05-07 1983-08-23 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US5244899A (en) * 1985-02-04 1993-09-14 G. D. Searle And Co. Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders
US5157053A (en) * 1985-02-04 1992-10-20 G. D. Searle & Co. Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
US5019597A (en) * 1985-02-04 1991-05-28 G. D. Searle & Co. Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5225444A (en) * 1985-02-04 1993-07-06 G. D. Searle & Co. Disubstituted 4-hydroxyphenylthio anilides
WO1987005012A2 (en) * 1986-02-21 1987-08-27 The Secretary Of State For Defence In Her Britanni Liquid crystal compounds, mixtures and devices
US4864038A (en) * 1986-05-05 1989-09-05 Merck & Co., Inc. Antihypercholesterolemic compounds
US5002967A (en) * 1987-06-05 1991-03-26 G. D. Searle & Co. Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
US4835189A (en) * 1987-06-05 1989-05-30 G. D. Searle & Co. Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
CZ280133B6 (cs) * 1991-11-25 1995-11-15 Eli Lilly And Company Substituovaný fenylfenolleukotrienový antagonist a farmaceutický prostředek, který ho obsahuje
ES2079997A1 (es) * 1993-06-15 1996-01-16 Lilly Co Eli Compuestos de fenil fenol sustituidos antagonistas de leucotrieno, procedimiento para su obtencion y formulaciones farmaceuticas de los mismos.
HRP950558A2 (en) * 1994-11-15 1997-12-31 Scott M. Wilhelm Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
ITRM20020014A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
ITRM20020629A1 (it) * 2002-12-19 2004-06-20 Sigma Tau Ind Farmaceuti Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.
ES2865182T3 (es) * 2014-12-29 2021-10-15 Nippon Chemiphar Co Inhibidor de URAT1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) * 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
LU38115A1 (enExample) * 1959-01-07
IL23268A (en) * 1964-05-07 1969-02-27 Merck & Co Inc Anti-inflammatory preparations containing the 4-phenyl-alpha-methyl acid acetic phenyl acid

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2060072A1 (enExample) * 1969-08-01 1971-06-11 Sumitomo Chemical Co
US4191776A (en) * 1974-05-20 1980-03-04 Boehringer Ingelheim Gmbh Biphenyl derivatives
FR2505818A1 (fr) * 1981-05-18 1982-11-19 Upjohn Co Procede de production d'un biphenyle substitue
EP0080010A1 (en) * 1981-11-24 1983-06-01 AUSONIA FARMACEUTICI S.r.l. Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
EP0080011A1 (en) * 1981-11-24 1983-06-01 AUSONIA FARMACEUTICI S.r.l. Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
WO1999020604A1 (de) * 1997-10-22 1999-04-29 Bayer Aktiengesellschaft S-(4-biphenyl)-thioschwefelsäuren und ihre salze, verfahren zu deren herstellung und die herstellung von 4-mercaptobiphenylen

Also Published As

Publication number Publication date
DE1593907C2 (de) 1973-01-04
NO120479B (enExample) 1970-10-26
BE696466A (enExample) 1967-10-02
CH493455A (de) 1970-07-15
CA926399A (en) 1973-05-15
IL27637A (en) 1972-02-29
US3652646A (en) 1972-03-28
DE1793705A1 (de) 1972-10-19
NL6704659A (enExample) 1967-10-02
ES340020A1 (es) 1968-05-16
JPS4916416B1 (enExample) 1974-04-22
FR6512M (enExample) 1968-12-02
DK117827B (da) 1970-06-08
DE1593907B1 (de) 1972-05-31
ES338692A1 (es) 1968-05-01

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