FR3097235B1 - Procede selectif de preparation de sulfones par catalyse enzymatique - Google Patents

Procede selectif de preparation de sulfones par catalyse enzymatique Download PDF

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Publication number
FR3097235B1
FR3097235B1 FR1906489A FR1906489A FR3097235B1 FR 3097235 B1 FR3097235 B1 FR 3097235B1 FR 1906489 A FR1906489 A FR 1906489A FR 1906489 A FR1906489 A FR 1906489A FR 3097235 B1 FR3097235 B1 FR 3097235B1
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FR
France
Prior art keywords
sulphones
preparation
enzymatic catalysis
selective process
symmetrical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1906489A
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English (en)
Other versions
FR3097235A1 (fr
Inventor
Georges Fremy
Hugo Brasselet
Véronique Alphand
Katia Duquesne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Arkema France SA
Original Assignee
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Arkema France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aix Marseille Universite, Centre National de la Recherche Scientifique CNRS, Arkema France SA filed Critical Aix Marseille Universite
Priority to FR1906489A priority Critical patent/FR3097235B1/fr
Priority to FR2002306A priority patent/FR3097233A1/fr
Priority to JP2021576014A priority patent/JP7565304B2/ja
Priority to PCT/FR2020/051014 priority patent/WO2020254745A1/fr
Priority to KR1020227001194A priority patent/KR20220020929A/ko
Priority to EP20743746.8A priority patent/EP3983554A1/fr
Priority to CN202080053771.0A priority patent/CN114174526A/zh
Priority to US17/619,479 priority patent/US20230016226A1/en
Publication of FR3097235A1 publication Critical patent/FR3097235A1/fr
Application granted granted Critical
Publication of FR3097235B1 publication Critical patent/FR3097235B1/fr
Priority to JP2024103419A priority patent/JP2024123241A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13022—Cyclohexanone monooxygenase (1.14.13.22)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne un procédé sélectif de préparation de sulfones à partir de sulfures par catalyse enzymatique, ainsi qu’une composition comprenant un sulfure symétrique, une enzyme oxydoréductase catalysant l’oxydation dudit sulfure symétrique en sulfone symétrique ; éventuellement au moins un cofacteur C de ladite enzyme E ; et un oxydant, permettant notamment de mettre en œuvre ledit procédé.
FR1906489A 2019-06-17 2019-06-17 Procede selectif de preparation de sulfones par catalyse enzymatique Active FR3097235B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR1906489A FR3097235B1 (fr) 2019-06-17 2019-06-17 Procede selectif de preparation de sulfones par catalyse enzymatique
FR2002306A FR3097233A1 (fr) 2019-06-17 2020-03-09 Procede selectif de preparation de sulfones par catalyse enzymatique
PCT/FR2020/051014 WO2020254745A1 (fr) 2019-06-17 2020-06-12 Procédé sélectif de préparation de sulfones par catalyse enzymatique
KR1020227001194A KR20220020929A (ko) 2019-06-17 2020-06-12 효소적 촉매작용에 의한 설폰 제조를 위한 선택적 방법
JP2021576014A JP7565304B2 (ja) 2019-06-17 2020-06-12 酵素触媒作用によりスルホンを調製するための選択的プロセス
EP20743746.8A EP3983554A1 (fr) 2019-06-17 2020-06-12 Procédé sélectif de préparation de sulfones par catalyse enzymatique
CN202080053771.0A CN114174526A (zh) 2019-06-17 2020-06-12 通过酶催化制备砜的选择性工艺
US17/619,479 US20230016226A1 (en) 2019-06-17 2020-06-12 Selective process for the preparation of sulfones by enzymatic catalysis
JP2024103419A JP2024123241A (ja) 2019-06-17 2024-06-26 酵素触媒作用によりスルホンを調製するための選択的プロセス

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1906489 2019-06-17
FR1906489A FR3097235B1 (fr) 2019-06-17 2019-06-17 Procede selectif de preparation de sulfones par catalyse enzymatique

Publications (2)

Publication Number Publication Date
FR3097235A1 FR3097235A1 (fr) 2020-12-18
FR3097235B1 true FR3097235B1 (fr) 2021-06-18

Family

ID=68210990

Family Applications (2)

Application Number Title Priority Date Filing Date
FR1906489A Active FR3097235B1 (fr) 2019-06-17 2019-06-17 Procede selectif de preparation de sulfones par catalyse enzymatique
FR2002306A Pending FR3097233A1 (fr) 2019-06-17 2020-03-09 Procede selectif de preparation de sulfones par catalyse enzymatique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR2002306A Pending FR3097233A1 (fr) 2019-06-17 2020-03-09 Procede selectif de preparation de sulfones par catalyse enzymatique

Country Status (7)

Country Link
US (1) US20230016226A1 (fr)
EP (1) EP3983554A1 (fr)
JP (2) JP7565304B2 (fr)
KR (1) KR20220020929A (fr)
CN (1) CN114174526A (fr)
FR (2) FR3097235B1 (fr)
WO (1) WO2020254745A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532656B2 (fr) 1982-06-02 1985-10-18 Elf Bio Rech Nouveau vecteur de clonage et d'expression, levure et bacterie transformees par ce vecteur
CN109402074B (zh) * 2018-11-05 2022-02-01 凯莱英医药集团（天津）股份有限公司 单加氧酶突变体及其应用

Also Published As

Publication number Publication date
FR3097235A1 (fr) 2020-12-18
US20230016226A1 (en) 2023-01-19
WO2020254745A1 (fr) 2020-12-24
JP2024123241A (ja) 2024-09-10
JP7565304B2 (ja) 2024-10-10
CN114174526A (zh) 2022-03-11
EP3983554A1 (fr) 2022-04-20
KR20220020929A (ko) 2022-02-21
FR3097233A1 (fr) 2020-12-18
JP2022549547A (ja) 2022-11-28

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