BR112014000495A2 - micro-organismos recombinante para a produção de metabólitos úteis - Google Patents

micro-organismos recombinante para a produção de metabólitos úteis

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Publication number
BR112014000495A2
BR112014000495A2 BR112014000495A BR112014000495A BR112014000495A2 BR 112014000495 A2 BR112014000495 A2 BR 112014000495A2 BR 112014000495 A BR112014000495 A BR 112014000495A BR 112014000495 A BR112014000495 A BR 112014000495A BR 112014000495 A2 BR112014000495 A2 BR 112014000495A2
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Prior art keywords
recombinant microorganisms
useful metabolites
production
activity
compared
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BR112014000495A
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English (en)
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Marlière Philippe
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Scientist Of Fortune Sa
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Application filed by Scientist Of Fortune Sa filed Critical Scientist Of Fortune Sa
Publication of BR112014000495A2 publication Critical patent/BR112014000495A2/pt

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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01011—6-Phosphofructokinase (2.7.1.11)
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03011—Fructose-bisphosphatase (3.1.3.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)
    • C—CHEMISTRY; METALLURGY
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02022—Fructose-6-phosphate phosphoketolase (4.1.2.22)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo patente de invenção: "micro-organismos recombinante para a produção de metabólitos úteis". a presente invenção refere-se a micro-organismos recombinantes caracterizados por ter atividade de fosfocetalose, tendo uma trajetória de embden-meyerhof-parnas diminuída ou inativada(empp) por inativação do(s) gene(s) que codifica(m) fosfofrutocinase ou por redução de atividade fosfofrutocinase quando comparada com um micro-organismo não modificado e tendo uma ramificação oxidada inativada ou diminuída da trajetória pento fosfatase (ppp) por inativação do(s) gene(s) que codifica(m) desidrogenase de glicose-6-fosfato ou por redução de atividade de desidrogenase de glicose-6-fosfato quando comparada com um micro-organismo não modificado. esses micro-organismos podem ser usados para a produção de metabólitos úteis tal como acetona, isobuteno ou propeno. 20202706v1
BR112014000495A 2011-07-12 2012-07-12 micro-organismos recombinante para a produção de metabólitos úteis BR112014000495A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11173563 2011-07-12
PCT/EP2012/063685 WO2013007786A1 (en) 2011-07-12 2012-07-12 Recombinant microorganism for the production of useful metabolites

Publications (1)

Publication Number Publication Date
BR112014000495A2 true BR112014000495A2 (pt) 2017-02-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000495A BR112014000495A2 (pt) 2011-07-12 2012-07-12 micro-organismos recombinante para a produção de metabólitos úteis

Country Status (24)

Country Link
US (3) US9249430B2 (pt)
EP (2) EP3031911B1 (pt)
JP (1) JP6207505B2 (pt)
KR (1) KR101989637B1 (pt)
CN (1) CN103703123B (pt)
AU (1) AU2012282520B2 (pt)
BR (1) BR112014000495A2 (pt)
CA (1) CA2841175C (pt)
CO (1) CO7020849A2 (pt)
DK (1) DK2732031T3 (pt)
ES (1) ES2554814T3 (pt)
GT (1) GT201400004A (pt)
HK (1) HK1196849A1 (pt)
IL (1) IL230030B (pt)
IN (1) IN2014DN00099A (pt)
MX (1) MX348706B (pt)
MY (1) MY163334A (pt)
PE (1) PE20141519A1 (pt)
PL (1) PL2732031T3 (pt)
PT (1) PT2732031E (pt)
RS (1) RS54444B1 (pt)
RU (1) RU2658770C2 (pt)
SG (1) SG2014012520A (pt)
WO (1) WO2013007786A1 (pt)

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