MX2009003925A - Metodos y composiciones para el tratamiento de enfermedades vaginales, empleando enzimas que producen peroxido y peroxidasas. - Google Patents
Metodos y composiciones para el tratamiento de enfermedades vaginales, empleando enzimas que producen peroxido y peroxidasas.Info
- Publication number
- MX2009003925A MX2009003925A MX2009003925A MX2009003925A MX2009003925A MX 2009003925 A MX2009003925 A MX 2009003925A MX 2009003925 A MX2009003925 A MX 2009003925A MX 2009003925 A MX2009003925 A MX 2009003925A MX 2009003925 A MX2009003925 A MX 2009003925A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- peroxidases
- compositions
- methods
- vaginal diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03004—Glucose oxidase (1.1.3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/02—Oxidoreductases acting on a peroxide as acceptor (1.11) with H2O2 as acceptor, one oxygen atom of which is incorporated into the product (1.11.2)
- C12Y111/02002—Myeloperoxidase (1.11.2.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición terapéutica para administración vaginal con base en la generación de un anión biocida por medio de una reacción enzimática catalizada por una peroxidasa; la peroxidasa utilizada por la enzima de proxidasa puede ser endógeno o puede generarse por la acción de una enzima de oxidasa en un substrato adecuado; las composiciones terapéuticas de acuerdo con esta invención son útiles para el tratamiento de enfermedades y afecciones vaginales que incluyen infecciones bacterianas y fúngicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82893306P | 2006-10-10 | 2006-10-10 | |
PCT/US2007/079840 WO2008045696A2 (en) | 2006-10-10 | 2007-09-28 | Methods and compositions for the treatment of vaginal diseases employing peroxide-producing enzymes and peroxidases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003925A true MX2009003925A (es) | 2009-10-26 |
Family
ID=39283509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003925A MX2009003925A (es) | 2006-10-10 | 2007-09-28 | Metodos y composiciones para el tratamiento de enfermedades vaginales, empleando enzimas que producen peroxido y peroxidasas. |
Country Status (9)
Country | Link |
---|---|
US (2) | US20100111920A1 (es) |
EP (1) | EP2073836A4 (es) |
JP (2) | JP5337701B2 (es) |
KR (1) | KR20090094245A (es) |
AU (1) | AU2007307921B2 (es) |
BR (1) | BRPI0719220A2 (es) |
CA (1) | CA2673497A1 (es) |
MX (1) | MX2009003925A (es) |
WO (1) | WO2008045696A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5337701B2 (ja) * | 2006-10-10 | 2013-11-06 | ラクリード、インコーポレイテッド | ペルオキシド生成酵素及びペルオキシダーゼを使用した膣疾患の治療のための方法及び組成物 |
GB2451452A (en) * | 2007-07-30 | 2009-02-04 | Donald Henry Yates | A lubricant formulation |
EP2510944A1 (en) * | 2011-04-15 | 2012-10-17 | National University of Ireland, Galway | Treatment of bacterial infections |
FR2980974B1 (fr) | 2011-10-10 | 2014-02-21 | Alaxia | Composition comprenant un sel d'hypothiocyanite d'un cation alcalin, a l'etat solide |
CA2975197A1 (en) * | 2015-02-03 | 2016-08-11 | Matoke Holdings Limited | Antimicrobial fibers and compositions |
EP3085417A1 (de) * | 2015-04-24 | 2016-10-26 | COR S.a.r.l. | Gleitmittel |
US9833720B2 (en) | 2015-06-22 | 2017-12-05 | Kma Concepts Limited | Clip launcher system with interconnecting projectile |
ES2685002B1 (es) * | 2017-03-31 | 2019-07-17 | Itf Res Pharma Slu | Formulaciones lubricantes |
CN107130004A (zh) * | 2017-07-03 | 2017-09-05 | 东北农业大学 | 玉米缪与大豆水酶法水解液混合发酵酒精的方法 |
GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
JP7281729B2 (ja) * | 2019-01-30 | 2023-05-26 | 学校法人帝京大学 | 抗真菌用組成物 |
CN112458027B (zh) * | 2020-12-16 | 2022-08-02 | 江南大学 | 一株格氏乳杆菌及其缓解和治疗高尿酸血症的用途 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178362A (en) * | 1969-06-03 | 1979-12-11 | Telec S.A. | Enzymatic dentifrices |
US4340448A (en) * | 1978-08-28 | 1982-07-20 | University Of Pittsburgh | Potentiometric detection of hydrogen peroxide and apparatus therefor |
US4269822A (en) * | 1979-07-20 | 1981-05-26 | Laclede Professional Products, Inc. | Antiseptic dentifrice |
US4578265A (en) * | 1981-08-13 | 1986-03-25 | Laclede Professional Products, Inc. | Di-enzymatic dentifrice |
US4370199A (en) * | 1981-11-09 | 1983-01-25 | Westvaco Corporation | Enzymatic catalyzed biocide system |
US4564519A (en) * | 1983-06-06 | 1986-01-14 | Laclede Professional Products, Inc. | Di-enzymatic chewable dentifrice |
US4576817A (en) * | 1984-06-07 | 1986-03-18 | Laclede Professional Products, Inc. | Enzymatic bandages and pads |
US4578365A (en) * | 1984-11-26 | 1986-03-25 | General Electric Company | High thermal conductivity ceramic body of aluminum nitride |
FR2574160A1 (fr) * | 1984-11-30 | 1986-06-06 | Electricite De France | Grille de foyer realisee a partir d'elements permettant un controle ameliore de l'apport en air primaire |
DK501686A (da) * | 1986-10-20 | 1988-04-21 | Otto Melchior Poulsen | Enzymholdigt, baktericidt middel samt tandplejemidler og saarbehandlingsmidler, som indeholder det |
SE8702831L (sv) * | 1987-07-10 | 1989-01-11 | Ewos Ab | Microbicid komposition |
JPH0248534A (ja) * | 1988-07-28 | 1990-02-19 | Bio Serae Sa:Soc | 抗菌組成物の配合方法及び配合された抗菌組成物 |
GB9002422D0 (en) * | 1990-02-03 | 1990-04-04 | Boots Co Plc | Anti-microbial compositions |
GB9015910D0 (en) * | 1990-07-19 | 1990-09-05 | Univ Bruxelles | Novel use |
US5389369A (en) * | 1991-02-21 | 1995-02-14 | Exoxemis, Inc. | Halo peroxidase containing compositions for killing yeast and sporular microorganisms |
US5336494A (en) * | 1993-01-29 | 1994-08-09 | Pellico Michael A | Pet chewable products with enzymatic coating |
US5453284A (en) * | 1993-01-29 | 1995-09-26 | Pellico; Michael A. | Stabilized enzymatic dentifrice |
WO1997042825A1 (en) * | 1996-05-09 | 1997-11-20 | Novo Nordisk A/S | Antimicrobial peroxidase compositions |
US5972355A (en) * | 1997-09-30 | 1999-10-26 | E-L Management Corp. | Stable compositions containing biologically active components |
US6214339B1 (en) * | 2000-01-12 | 2001-04-10 | Michael A. Pellico | Di-enzymatic treatment of outer ear infection in dogs and cats |
GB0100643D0 (en) * | 2001-01-10 | 2001-02-21 | Basf Ag | Liquid antimicrobial compositions |
WO2003066001A2 (en) * | 2002-02-07 | 2003-08-14 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
KR101108439B1 (ko) * | 2002-10-25 | 2012-01-31 | 포믹스 리미티드 | 화장료 및 약제용 거품제 |
FR2860154B1 (fr) * | 2003-09-29 | 2006-02-03 | Chris Cardon | Composition pour le traitement de la mauvaise haleine |
JP4355592B2 (ja) * | 2004-02-23 | 2009-11-04 | 森永乳業株式会社 | 抗ウイルス剤 |
WO2005085287A1 (en) * | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
DE602006003760D1 (de) * | 2005-06-13 | 2009-01-22 | Flen Pharma N V | Zungen |
CA2687128C (en) * | 2006-05-10 | 2017-03-28 | Laclede, Inc. | Compositions and methods for enzymatic treatment of lung disorders |
JP5337701B2 (ja) * | 2006-10-10 | 2013-11-06 | ラクリード、インコーポレイテッド | ペルオキシド生成酵素及びペルオキシダーゼを使用した膣疾患の治療のための方法及び組成物 |
KR20150041172A (ko) * | 2006-12-01 | 2015-04-15 | 래크리드 인코포레이티드 | 귀에서 균막을 용해시키기 위한 가수분해 및 산화 효소의 용도 |
-
2007
- 2007-09-28 JP JP2009532497A patent/JP5337701B2/ja active Active
- 2007-09-28 EP EP07815021A patent/EP2073836A4/en not_active Ceased
- 2007-09-28 BR BRPI0719220-7A patent/BRPI0719220A2/pt active Search and Examination
- 2007-09-28 US US12/445,239 patent/US20100111920A1/en not_active Abandoned
- 2007-09-28 CA CA002673497A patent/CA2673497A1/en not_active Abandoned
- 2007-09-28 MX MX2009003925A patent/MX2009003925A/es active IP Right Grant
- 2007-09-28 WO PCT/US2007/079840 patent/WO2008045696A2/en active Application Filing
- 2007-09-28 AU AU2007307921A patent/AU2007307921B2/en not_active Ceased
- 2007-09-28 KR KR1020097009592A patent/KR20090094245A/ko active Application Filing
-
2013
- 2013-03-13 JP JP2013050525A patent/JP5668200B2/ja active Active
-
2016
- 2016-05-10 US US15/151,315 patent/US20160279206A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20160279206A1 (en) | 2016-09-29 |
JP5668200B2 (ja) | 2015-02-12 |
WO2008045696A2 (en) | 2008-04-17 |
CA2673497A1 (en) | 2008-04-17 |
JP5337701B2 (ja) | 2013-11-06 |
EP2073836A4 (en) | 2010-04-07 |
KR20090094245A (ko) | 2009-09-04 |
AU2007307921B2 (en) | 2013-03-28 |
EP2073836A2 (en) | 2009-07-01 |
AU2007307921A2 (en) | 2009-05-21 |
JP2010505959A (ja) | 2010-02-25 |
BRPI0719220A2 (pt) | 2014-03-18 |
AU2007307921A1 (en) | 2008-04-17 |
US20100111920A1 (en) | 2010-05-06 |
WO2008045696A3 (en) | 2009-04-16 |
JP2013107914A (ja) | 2013-06-06 |
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