FR2878749B1 - Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives - Google Patents

Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives

Info

Publication number
FR2878749B1
FR2878749B1 FR0412870A FR0412870A FR2878749B1 FR 2878749 B1 FR2878749 B1 FR 2878749B1 FR 0412870 A FR0412870 A FR 0412870A FR 0412870 A FR0412870 A FR 0412870A FR 2878749 B1 FR2878749 B1 FR 2878749B1
Authority
FR
France
Prior art keywords
vegt
derivatives
combinations containing
inhibitor agent
antitumor combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0412870A
Other languages
English (en)
French (fr)
Other versions
FR2878749A1 (fr
Inventor
Patricia Vrignaud
Blondel Marielle Chiron
Marie Christine Bissery
Eric Furfine
Jocelyn Holash
Jess M Cedarbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Mature Ip Fr
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34954452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2878749(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0412870A priority Critical patent/FR2878749B1/fr
Priority to HK08104697.0A priority patent/HK1114769B/xx
Priority to BRPI0518700A priority patent/BRPI0518700B8/pt
Priority to CN2005800416406A priority patent/CN101068564B/zh
Priority to DK05824581T priority patent/DK1824504T3/da
Priority to AU2005311191A priority patent/AU2005311191C1/en
Priority to PT05824581T priority patent/PT1824504E/pt
Priority to JP2007543885A priority patent/JP4980236B2/ja
Priority to MX2007006607A priority patent/MX2007006607A/es
Priority to AT05824581T priority patent/ATE426409T1/de
Priority to RSP-2009/0272A priority patent/RS50769B/sr
Priority to US11/293,761 priority patent/US20060178305A1/en
Priority to RU2007123607/15A priority patent/RU2384344C2/ru
Priority to PL05824581T priority patent/PL1824504T3/pl
Priority to DE602005013568T priority patent/DE602005013568D1/de
Priority to EP05824581A priority patent/EP1824504B1/fr
Priority to CA2586735A priority patent/CA2586735C/fr
Priority to SI200530696T priority patent/SI1824504T1/sl
Priority to KR1020077012431A priority patent/KR101313404B1/ko
Priority to ES05824581T priority patent/ES2324233T3/es
Priority to MEP-2009-272A priority patent/ME01706B/me
Priority to PCT/FR2005/003005 priority patent/WO2006059012A1/fr
Priority to HR20090336T priority patent/HRP20090336T1/xx
Publication of FR2878749A1 publication Critical patent/FR2878749A1/fr
Priority to IL183481A priority patent/IL183481A/en
Publication of FR2878749B1 publication Critical patent/FR2878749B1/fr
Application granted granted Critical
Priority to CY20091100671T priority patent/CY1109181T1/el
Priority to US12/508,834 priority patent/US8388963B2/en
Priority to US13/783,919 priority patent/US20130184205A1/en
Priority to FR13C0024C priority patent/FR13C0024I1/fr
Priority to FR13C0025C priority patent/FR13C0025I1/fr
Priority to CY2013017C priority patent/CY2013017I1/el
Priority to CY2013018C priority patent/CY2013018I1/el
Priority to LU92202C priority patent/LU92202I2/fr
Priority to LU92203C priority patent/LU92203I2/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0412870A 2004-12-03 2004-12-03 Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives Expired - Lifetime FR2878749B1 (fr)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR0412870A FR2878749B1 (fr) 2004-12-03 2004-12-03 Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives
KR1020077012431A KR101313404B1 (ko) 2004-12-03 2005-12-02 Ｖｅｇｆ 저해제 및 5ｆｕ 또는 그의 유도체들 중 하나를포함하는 항종양 조합물
ES05824581T ES2324233T3 (es) 2004-12-03 2005-12-02 Combinaciones antitumorales que contienen vegf-trap y 5fu o uno de sus derivados.
CN2005800416406A CN101068564B (zh) 2004-12-03 2005-12-02 含有vegf抑制剂与5fu或其中一种衍生物的抗肿瘤组合物
DK05824581T DK1824504T3 (da) 2004-12-03 2005-12-02 Anti-tumor-kombinationer, der indeholder VEGF-trap og 5-fluoruracil eller et derivat deraf
AU2005311191A AU2005311191C1 (en) 2004-12-03 2005-12-02 Antitumor combinations containing a VEGF inhibitor and 5FU or one of its derivatives
PCT/FR2005/003005 WO2006059012A1 (fr) 2004-12-03 2005-12-02 Combinaisons antitumorales contenant un agent inhibiteur de vegf et du 5fu ou un de ses derives
JP2007543885A JP4980236B2 (ja) 2004-12-03 2005-12-02 Ｖｅｇｆ阻害剤および５ｆｕまたはこの誘導体の１つを含有する抗腫瘍組合せ物
MX2007006607A MX2007006607A (es) 2004-12-03 2005-12-02 Combinaciones antitumorales que contienen un agente inhibidor de vegf y de 5fu o uno de sus derivados.
AT05824581T ATE426409T1 (de) 2004-12-03 2005-12-02 Antitumor-kombinationen mit vegf-trap und 5fu oder einem seiner derivate
RSP-2009/0272A RS50769B (sr) 2004-12-03 2005-12-02 Antitumorska kombinacija koja sadrži vegf-zamku i 5fu ili jedan od njegovih derivata
US11/293,761 US20060178305A1 (en) 2004-12-03 2005-12-02 Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof
RU2007123607/15A RU2384344C2 (ru) 2004-12-03 2005-12-02 Противоопухолевые комбинации, содержащие агент, ингибирующий vegf и 5fu или одно из его производных
PL05824581T PL1824504T3 (pl) 2004-12-03 2005-12-02 Kombinacja przeciwnowotworowa zawierająca vegf-trap i 5fu lub jedną z jego pochodnych
DE602005013568T DE602005013568D1 (de) 2004-12-03 2005-12-02 Antitumor-kombinationen mit vegf-trap und 5fu oder einem seiner derivate
EP05824581A EP1824504B1 (fr) 2004-12-03 2005-12-02 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives
CA2586735A CA2586735C (fr) 2004-12-03 2005-12-02 Combinaisons antitumorales contenant un agent inhibiteur de vegf et du 5fu ou un de ses derives
SI200530696T SI1824504T1 (sl) 2004-12-03 2005-12-02 Protitumorske kombinacije, ki vsebujejo vegf-trap in 5fu ali enega od njegovih derivatov
HK08104697.0A HK1114769B (en) 2004-12-03 2005-12-02 Antitumor combinations containing a vegf inhibitor and 5fu or one of its derivative
MEP-2009-272A ME01706B (me) 2004-12-03 2005-12-02 Antitumorska kombinacija koja sadrži vegf-zamku i 5fu ili jedan od njegovih derivata
BRPI0518700A BRPI0518700B8 (pt) 2004-12-03 2005-12-02 combinação contendo vegf-trap, 5-fluorouracila e ácido folínico
PT05824581T PT1824504E (pt) 2004-12-03 2005-12-02 Combinações antitumorais contendo vegf-trap e 5fu ou um de seus derivados
HR20090336T HRP20090336T1 (hr) 2004-12-03 2005-12-02 Antitumorske kombinacije koje sadrže zamku za vegf i 5-fu ili jedan od njegovih derivata
IL183481A IL183481A (en) 2004-12-03 2007-05-28 Combinations containing vegf-trap with 5-fluorouracil are useful in the treatment of neoplastic diseases
CY20091100671T CY1109181T1 (el) 2004-12-03 2009-06-25 Αντικαρκινικοι συνδυασμοι που περιεχουν vegf-trap και 5fu ή ενα εκ των παραγωγων αυτων.
US12/508,834 US8388963B2 (en) 2004-12-03 2009-07-24 Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof
US13/783,919 US20130184205A1 (en) 2004-12-03 2013-03-04 Antitumor combinations containing a vegf-inhibiting agent and 5fu or a derivative thereof
FR13C0024C FR13C0024I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives
FR13C0025C FR13C0025I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives
CY2013018C CY2013018I1 (el) 2004-12-03 2013-05-13 Αντικαρκινικοι συνδυασμοι που περιεχουν vegf-trap και 5fu ή ενα εκ των παραγωγων αυτων.
CY2013017C CY2013017I1 (el) 2004-12-03 2013-05-13 Αντικαρκινικοι συνδυασμοι που περιεχουν vegf-trap και 5fu ή ενα εκ των παραγωγων αυτων.
LU92202C LU92202I2 (fr) 2004-12-03 2013-05-15 Aflibercept
LU92203C LU92203I2 (fr) 2004-12-03 2013-05-15 Aflibercept en combination avec 5-FU

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0412870A FR2878749B1 (fr) 2004-12-03 2004-12-03 Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives

Publications (2)

Publication Number Publication Date
FR2878749A1 FR2878749A1 (fr) 2006-06-09
FR2878749B1 true FR2878749B1 (fr) 2007-12-21

Family

ID=34954452

Family Applications (3)

Application Number Title Priority Date Filing Date
FR0412870A Expired - Lifetime FR2878749B1 (fr) 2004-12-03 2004-12-03 Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives
FR13C0025C Active FR13C0025I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives
FR13C0024C Active FR13C0024I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR13C0025C Active FR13C0025I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives
FR13C0024C Active FR13C0024I1 (fr) 2004-12-03 2013-04-22 Combinaisons antitumorales contenant vegf-trap et du 5fu ou un de ses derives

Country Status (25)

Country Link
US (3) US20060178305A1 (enExample)
EP (1) EP1824504B1 (enExample)
JP (1) JP4980236B2 (enExample)
KR (1) KR101313404B1 (enExample)
CN (1) CN101068564B (enExample)
AT (1) ATE426409T1 (enExample)
AU (1) AU2005311191C1 (enExample)
BR (1) BRPI0518700B8 (enExample)
CA (1) CA2586735C (enExample)
CY (3) CY1109181T1 (enExample)
DE (1) DE602005013568D1 (enExample)
DK (1) DK1824504T3 (enExample)
ES (1) ES2324233T3 (enExample)
FR (3) FR2878749B1 (enExample)
HR (1) HRP20090336T1 (enExample)
IL (1) IL183481A (enExample)
LU (2) LU92202I2 (enExample)
ME (1) ME01706B (enExample)
MX (1) MX2007006607A (enExample)
PL (1) PL1824504T3 (enExample)
PT (1) PT1824504E (enExample)
RS (1) RS50769B (enExample)
RU (1) RU2384344C2 (enExample)
SI (1) SI1824504T1 (enExample)
WO (1) WO2006059012A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
WO2015200905A2 (en) 2014-06-28 2015-12-30 Oligasis, Llc Dual pdgf/vegf antagonists
RS58957B1 (sr) 2014-07-18 2019-08-30 Sanofi Sa Postupak za predviđanje ishoda tretmana sa afliberceptom kod pacijenta za kog se sumnja da boluje od raka
IL290457B2 (en) 2015-12-30 2025-02-01 Kodiak Sciences Inc Antibodies and their conjugates
EP3246029A1 (en) * 2016-05-19 2017-11-22 Boehringer Ingelheim International Gmbh Pharmaceutical combination of nintedanib and capecitabine for the treatment of colorectal cancer
CA3092588A1 (en) 2018-03-02 2019-09-06 Kodiak Sciences Inc. Il-6 antibodies and fusion constructs and conjugates thereof
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
CN115197948A (zh) * 2021-04-13 2022-10-18 江苏康缘瑞翱生物医药科技有限公司 一种重组新城疫病毒rNDV-VEGF-Trap、其基因组、制备方法及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9701081D0 (en) * 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
CN101433715B (zh) * 1999-06-08 2013-04-17 里珍纳龙药品有限公司 具有改善的药物动力学特性的修饰嵌合多肽
US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
AR046510A1 (es) * 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo

Also Published As

Publication number Publication date
SI1824504T1 (sl) 2009-08-31
MX2007006607A (es) 2007-07-25
KR101313404B1 (ko) 2013-10-01
ATE426409T1 (de) 2009-04-15
AU2005311191C1 (en) 2015-04-30
LU92203I2 (fr) 2013-11-15
PL1824504T3 (pl) 2009-08-31
US20060178305A1 (en) 2006-08-10
HK1114769A1 (en) 2008-11-14
AU2005311191A1 (en) 2006-06-08
CY2013018I1 (el) 2020-05-29
AU2005311191B2 (en) 2011-12-08
CN101068564A (zh) 2007-11-07
CA2586735C (fr) 2014-08-12
FR13C0025I1 (fr) 2013-05-24
LU92203I9 (enExample) 2019-01-15
WO2006059012A1 (fr) 2006-06-08
EP1824504A1 (fr) 2007-08-29
DE602005013568D1 (de) 2009-05-07
LU92202I9 (enExample) 2019-01-15
FR13C0024I1 (fr) 2013-05-24
ES2324233T3 (es) 2009-08-03
BRPI0518700B1 (pt) 2020-02-11
RS50769B (sr) 2010-08-31
FR2878749A1 (fr) 2006-06-09
CN101068564B (zh) 2010-12-15
IL183481A0 (en) 2007-09-20
US8388963B2 (en) 2013-03-05
BRPI0518700A2 (pt) 2008-12-02
KR20070091130A (ko) 2007-09-07
CY2013017I1 (el) 2014-07-02
CY1109181T1 (el) 2014-07-02
EP1824504B1 (fr) 2009-03-25
DK1824504T3 (da) 2009-07-20
ME01706B (me) 2010-08-31
US20090285841A1 (en) 2009-11-19
LU92202I2 (fr) 2013-11-15
CA2586735A1 (fr) 2006-06-08
RU2007123607A (ru) 2009-01-10
HRP20090336T1 (hr) 2009-07-31
JP4980236B2 (ja) 2012-07-18
PT1824504E (pt) 2009-06-25
IL183481A (en) 2013-09-30
US20130184205A1 (en) 2013-07-18
RU2384344C2 (ru) 2010-03-20
BRPI0518700B8 (pt) 2021-05-25
JP2008521866A (ja) 2008-06-26

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