FR2847263B1 - Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans - Google Patents
Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhansInfo
- Publication number
- FR2847263B1 FR2847263B1 FR0214374A FR0214374A FR2847263B1 FR 2847263 B1 FR2847263 B1 FR 2847263B1 FR 0214374 A FR0214374 A FR 0214374A FR 0214374 A FR0214374 A FR 0214374A FR 2847263 B1 FR2847263 B1 FR 2847263B1
- Authority
- FR
- France
- Prior art keywords
- cells
- sequence
- nucleic acid
- protein
- iia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 230000004075 alteration Effects 0.000 abstract 2
- 230000003321 amplification Effects 0.000 abstract 2
- 230000003178 anti-diabetic effect Effects 0.000 abstract 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 210000004153 islets of langerhan Anatomy 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 108091060211 Expressed sequence tag Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 108090000702 Zinc Transporter 8 Proteins 0.000 abstract 1
- 102000004248 Zinc Transporter 8 Human genes 0.000 abstract 1
- 108091006550 Zinc transporters Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013599 cloning vector Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000028023 exocytosis Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214374A FR2847263B1 (fr) | 2002-11-18 | 2002-11-18 | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
| AT03786019T ATE408689T1 (de) | 2002-11-18 | 2003-11-18 | Protein spezifisch für die pankreatischen beta- zellen der langerhans-inseln, und seine verwendungen |
| ES08002520T ES2361639T3 (es) | 2002-11-18 | 2003-11-18 | Proteína específica de células pancreáticas beta de los islotes de langerhans y sus aplicaciones. |
| EP10007471.5A EP2239272B1 (fr) | 2002-11-18 | 2003-11-18 | Protéine spécifique des cellules pancréatiques bêta des îlots de Langerhans et ses applications |
| US10/535,395 US7851164B2 (en) | 2002-11-18 | 2003-11-18 | Protein specific to pancreatic beta cells in islets of langerhans and applications thereof |
| DE60335676T DE60335676D1 (de) | 2002-11-18 | 2003-11-18 | Spezielles Protein der Pankreatischen Beta-Zellen der Langerhans-Inseln und seine Anwendungen |
| JP2004552811A JP4498144B2 (ja) | 2002-11-18 | 2003-11-18 | ランゲルハンス島の膵ベータ細胞に特異的なタンパク質およびその適用 |
| DE60323664T DE60323664D1 (de) | 2002-11-18 | 2003-11-18 | Len der langerhans-inseln, und seine verwendungen |
| EP03786019A EP1563071B1 (fr) | 2002-11-18 | 2003-11-18 | Proteine specifique des cellules pancreatiques beta des ilots de langerhans et ses applications. |
| DK03786019T DK1563071T3 (da) | 2002-11-18 | 2003-11-18 | Protein, som er specifikt for pankreatiske beta-celler fra Langerhans-öer, og anvendelser deraf |
| PCT/FR2003/003413 WO2004046355A2 (fr) | 2002-11-18 | 2003-11-18 | Proteine specifique des cellules pancreatiques beta des ilots de langerhans et ses applications. |
| CN2003801088861A CN1738900B (zh) | 2002-11-18 | 2003-11-18 | 特异于胰腺胰岛β细胞的蛋白质及其应用 |
| EP08002520A EP1925667B1 (fr) | 2002-11-18 | 2003-11-18 | Protéine spécifique des cellules pancréatiques bêta des îlots de Langerhans et ses applications |
| ES10007471.5T ES2454592T3 (es) | 2002-11-18 | 2003-11-18 | Proteína específica de células beta pancreáticas de los islotes de Langerhans y sus aplicaciones |
| AU2003295025A AU2003295025B2 (en) | 2002-11-18 | 2003-11-18 | Protein specific to pancreatic beta cells in islets of Langerhans and applications thereof |
| AT08002520T ATE494376T1 (de) | 2002-11-18 | 2003-11-18 | Spezielles protein der pankreatischen beta-zellen der langerhans-inseln und seine anwendungen |
| ES03786019T ES2314268T3 (es) | 2002-11-18 | 2003-11-18 | Proteina especifica de celulas pancreaticas beta de los islotes de langerhans y sus aplicaciones. |
| CN2011101575572A CN102250242A (zh) | 2002-11-18 | 2003-11-18 | 特异于胰腺胰岛β细胞的蛋白质及其应用 |
| CA2506331A CA2506331C (fr) | 2002-11-18 | 2003-11-18 | Proteine specifique des cellules pancreatiques beta des ilots de langerhans et ses applications |
| DK08002520.8T DK1925667T3 (da) | 2002-11-18 | 2003-11-18 | Protein, som er specifikt for de pankreatiske beta-celler i de langerhanske øer, og dets anvendelser |
| JP2010005852A JP5202550B2 (ja) | 2002-11-18 | 2010-01-14 | ランゲルハンス島の膵ベータ細胞に特異的なタンパク質およびその適用 |
| US12/907,695 US9568482B2 (en) | 2002-11-18 | 2010-10-19 | Antibodies specific for ZNT8 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214374A FR2847263B1 (fr) | 2002-11-18 | 2002-11-18 | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2847263A1 FR2847263A1 (fr) | 2004-05-21 |
| FR2847263B1 true FR2847263B1 (fr) | 2006-01-13 |
Family
ID=32187667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0214374A Expired - Fee Related FR2847263B1 (fr) | 2002-11-18 | 2002-11-18 | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7851164B2 (enExample) |
| EP (3) | EP1563071B1 (enExample) |
| JP (2) | JP4498144B2 (enExample) |
| CN (2) | CN1738900B (enExample) |
| AT (2) | ATE494376T1 (enExample) |
| AU (1) | AU2003295025B2 (enExample) |
| CA (1) | CA2506331C (enExample) |
| DE (2) | DE60335676D1 (enExample) |
| DK (2) | DK1925667T3 (enExample) |
| ES (3) | ES2361639T3 (enExample) |
| FR (1) | FR2847263B1 (enExample) |
| WO (1) | WO2004046355A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008065544A2 (en) * | 2006-09-11 | 2008-06-05 | Mcgill University | Genetic predictors of risk for type 2 diabetes mellitus |
| US9023984B2 (en) | 2006-12-29 | 2015-05-05 | The Regents Of The University Of Colorado, A Body Corporate | Diagnostic and therapeutic target for autoimmune diseases and uses thereof |
| WO2008096009A2 (en) * | 2007-02-09 | 2008-08-14 | Mellitech | Polymorphism in the slc30a8 gene |
| JP5697995B2 (ja) * | 2008-02-14 | 2015-04-08 | ユニヴァルシテ リブレ デ ブリュッセル | β細胞の画像化又は標的化において有用な、膵β細胞において優先的に発現される新たな細胞膜バイオマーカー |
| EP2334696A1 (en) * | 2008-09-30 | 2011-06-22 | Novo Nordisk A/S | G6pc2-encoded beta cell surface tags |
| US20120070847A1 (en) | 2008-11-07 | 2012-03-22 | Jan Jensen | Method For Detecting And Purifying Pancreatic Beta Cells |
| ES2585360T3 (es) * | 2009-08-05 | 2016-10-05 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS) |
| EP2537859A1 (en) | 2011-06-23 | 2012-12-26 | Université de Mons | Molecules specifically binding pancreatic beta cells biomarkers |
| ES2684976T3 (es) | 2012-04-13 | 2018-10-05 | Diabetomics, Inc. | Biomarcadores maternos para diabetes gestacional |
| CN104098675A (zh) * | 2013-04-03 | 2014-10-15 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
| CN104098673A (zh) * | 2013-04-03 | 2014-10-15 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
| EP3123169B1 (en) * | 2014-03-26 | 2022-05-04 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Flattop (fltp) is a novel biomarker for beta cell maturation |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| GB201520603D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| US11016085B2 (en) | 2016-04-25 | 2021-05-25 | The Johns Hopkins University | ZNT8 assays for drug development and pharmaceutical compositions |
| CN106226526A (zh) * | 2016-06-30 | 2016-12-14 | 深圳市亚辉龙生物科技股份有限公司 | 一种锌转运蛋白8抗体化学发光免疫检测试剂盒及其制备方法 |
| US11892457B2 (en) | 2017-07-12 | 2024-02-06 | The Johns Hopkins University | Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis |
| CN113166241B (zh) * | 2018-08-16 | 2025-02-25 | 约翰霍普金斯大学 | 人类znt8抗体 |
| CN109734793B (zh) * | 2019-03-14 | 2022-12-02 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | 一种ZnT8重组蛋白及其制备方法和应用 |
| WO2021030613A1 (en) * | 2019-08-13 | 2021-02-18 | Amgen Inc. | Rnai constructs for inhibiting slc30a8 expression and methods of use thereof |
| US12366570B2 (en) | 2019-10-01 | 2025-07-22 | The Johns Hopkins University | Cell-based ZNT8 assay |
| JP2024534047A (ja) | 2021-08-20 | 2024-09-18 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 膵臓ベータ細胞の特定のバイオマーカーに対する細胞表面抗体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| NL9001083A (nl) | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | Beta-cel antigeen. |
| ZA97476B (en) * | 1996-01-22 | 1998-07-21 | Res Dev Foundation | Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells. |
| AU778155B2 (en) * | 1999-12-13 | 2004-11-18 | Scripps Research Institute, The | Markers for identification and isolation of pancreatic islet alpha and beta cell progenitors |
| WO2001094409A2 (en) * | 2000-06-07 | 2001-12-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| CA2421576A1 (en) * | 2000-09-15 | 2002-03-28 | Curagen Corporation | Human polynucleotides and polypeptides encoded thereby |
| US7459539B2 (en) * | 2000-12-15 | 2008-12-02 | Agensys, Inc. | Antibody that binds zinc transporter protein 108P5H8 |
-
2002
- 2002-11-18 FR FR0214374A patent/FR2847263B1/fr not_active Expired - Fee Related
-
2003
- 2003-11-18 DK DK08002520.8T patent/DK1925667T3/da active
- 2003-11-18 EP EP03786019A patent/EP1563071B1/fr not_active Expired - Lifetime
- 2003-11-18 CN CN2003801088861A patent/CN1738900B/zh not_active Expired - Fee Related
- 2003-11-18 CN CN2011101575572A patent/CN102250242A/zh active Pending
- 2003-11-18 EP EP10007471.5A patent/EP2239272B1/fr not_active Expired - Lifetime
- 2003-11-18 ES ES08002520T patent/ES2361639T3/es not_active Expired - Lifetime
- 2003-11-18 ES ES03786019T patent/ES2314268T3/es not_active Expired - Lifetime
- 2003-11-18 DK DK03786019T patent/DK1563071T3/da active
- 2003-11-18 JP JP2004552811A patent/JP4498144B2/ja not_active Expired - Fee Related
- 2003-11-18 DE DE60335676T patent/DE60335676D1/de not_active Expired - Lifetime
- 2003-11-18 AU AU2003295025A patent/AU2003295025B2/en not_active Ceased
- 2003-11-18 EP EP08002520A patent/EP1925667B1/fr not_active Expired - Lifetime
- 2003-11-18 WO PCT/FR2003/003413 patent/WO2004046355A2/fr not_active Ceased
- 2003-11-18 AT AT08002520T patent/ATE494376T1/de not_active IP Right Cessation
- 2003-11-18 AT AT03786019T patent/ATE408689T1/de not_active IP Right Cessation
- 2003-11-18 US US10/535,395 patent/US7851164B2/en not_active Expired - Fee Related
- 2003-11-18 CA CA2506331A patent/CA2506331C/fr not_active Expired - Fee Related
- 2003-11-18 ES ES10007471.5T patent/ES2454592T3/es not_active Expired - Lifetime
- 2003-11-18 DE DE60323664T patent/DE60323664D1/de not_active Expired - Lifetime
-
2010
- 2010-01-14 JP JP2010005852A patent/JP5202550B2/ja not_active Expired - Fee Related
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