CN1738900B - 特异于胰腺胰岛β细胞的蛋白质及其应用 - Google Patents

特异于胰腺胰岛β细胞的蛋白质及其应用 Download PDF

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CN1738900B
CN1738900B CN2003801088861A CN200380108886A CN1738900B CN 1738900 B CN1738900 B CN 1738900B CN 2003801088861 A CN2003801088861 A CN 2003801088861A CN 200380108886 A CN200380108886 A CN 200380108886A CN 1738900 B CN1738900 B CN 1738900B
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cell
polynucleotide
protein
seq
present
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CN1738900A (zh
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米歇尔·塞夫
阿兰·法维耶
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Joseph fourier university
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
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Commissariat a lEnergie Atomique CEA
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    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
CN2003801088861A 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用 Expired - Fee Related CN1738900B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0214374A FR2847263B1 (fr) 2002-11-18 2002-11-18 Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans
FR02/14374 2002-11-18
PCT/FR2003/003413 WO2004046355A2 (fr) 2002-11-18 2003-11-18 Proteine specifique des cellules pancreatiques beta des ilots de langerhans et ses applications.

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CN2011101575572A Division CN102250242A (zh) 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用

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CN1738900A CN1738900A (zh) 2006-02-22
CN1738900B true CN1738900B (zh) 2011-07-06

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CN2011101575572A Pending CN102250242A (zh) 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用

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US (2) US7851164B2 (enExample)
EP (3) EP1563071B1 (enExample)
JP (2) JP4498144B2 (enExample)
CN (2) CN1738900B (enExample)
AT (2) ATE494376T1 (enExample)
AU (1) AU2003295025B2 (enExample)
CA (1) CA2506331C (enExample)
DE (2) DE60335676D1 (enExample)
DK (2) DK1925667T3 (enExample)
ES (3) ES2361639T3 (enExample)
FR (1) FR2847263B1 (enExample)
WO (1) WO2004046355A2 (enExample)

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WO2008065544A2 (en) * 2006-09-11 2008-06-05 Mcgill University Genetic predictors of risk for type 2 diabetes mellitus
US9023984B2 (en) 2006-12-29 2015-05-05 The Regents Of The University Of Colorado, A Body Corporate Diagnostic and therapeutic target for autoimmune diseases and uses thereof
WO2008096009A2 (en) * 2007-02-09 2008-08-14 Mellitech Polymorphism in the slc30a8 gene
JP5697995B2 (ja) * 2008-02-14 2015-04-08 ユニヴァルシテ リブレ デ ブリュッセル β細胞の画像化又は標的化において有用な、膵β細胞において優先的に発現される新たな細胞膜バイオマーカー
EP2334696A1 (en) * 2008-09-30 2011-06-22 Novo Nordisk A/S G6pc2-encoded beta cell surface tags
US20120070847A1 (en) 2008-11-07 2012-03-22 Jan Jensen Method For Detecting And Purifying Pancreatic Beta Cells
ES2585360T3 (es) * 2009-08-05 2016-10-05 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
EP2537859A1 (en) 2011-06-23 2012-12-26 Université de Mons Molecules specifically binding pancreatic beta cells biomarkers
ES2684976T3 (es) 2012-04-13 2018-10-05 Diabetomics, Inc. Biomarcadores maternos para diabetes gestacional
CN104098675A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
CN104098673A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
EP3123169B1 (en) * 2014-03-26 2022-05-04 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Flattop (fltp) is a novel biomarker for beta cell maturation
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
US11016085B2 (en) 2016-04-25 2021-05-25 The Johns Hopkins University ZNT8 assays for drug development and pharmaceutical compositions
CN106226526A (zh) * 2016-06-30 2016-12-14 深圳市亚辉龙生物科技股份有限公司 一种锌转运蛋白8抗体化学发光免疫检测试剂盒及其制备方法
US11892457B2 (en) 2017-07-12 2024-02-06 The Johns Hopkins University Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis
CN113166241B (zh) * 2018-08-16 2025-02-25 约翰霍普金斯大学 人类znt8抗体
CN109734793B (zh) * 2019-03-14 2022-12-02 深圳市药品检验研究院（深圳市医疗器械检测中心） 一种ZnT8重组蛋白及其制备方法和应用
WO2021030613A1 (en) * 2019-08-13 2021-02-18 Amgen Inc. Rnai constructs for inhibiting slc30a8 expression and methods of use thereof
US12366570B2 (en) 2019-10-01 2025-07-22 The Johns Hopkins University Cell-based ZNT8 assay
JP2024534047A (ja) 2021-08-20 2024-09-18 ザ・ジョンズ・ホプキンス・ユニバーシティ 膵臓ベータ細胞の特定のバイオマーカーに対する細胞表面抗体

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ATE408689T1 (de) 2008-10-15
CN102250242A (zh) 2011-11-23
US20060246442A1 (en) 2006-11-02
DK1563071T3 (da) 2009-02-02
ES2314268T3 (es) 2009-03-16
WO2004046355A2 (fr) 2004-06-03
CA2506331A1 (fr) 2004-06-03
EP1563071A2 (fr) 2005-08-17
EP1925667B1 (fr) 2011-01-05
AU2003295025B2 (en) 2008-09-18
ES2361639T3 (es) 2011-06-20
DE60323664D1 (de) 2008-10-30
JP2010150262A (ja) 2010-07-08
EP2239272B1 (fr) 2014-01-01
FR2847263B1 (fr) 2006-01-13
CN1738900A (zh) 2006-02-22
JP2006506084A (ja) 2006-02-23
US9568482B2 (en) 2017-02-14
FR2847263A1 (fr) 2004-05-21
ES2454592T3 (es) 2014-04-11
WO2004046355A3 (fr) 2004-09-30
US7851164B2 (en) 2010-12-14
DK1925667T3 (da) 2011-04-26
EP2239272A2 (fr) 2010-10-13
AU2003295025A1 (en) 2004-06-15
CA2506331C (fr) 2015-02-17
ATE494376T1 (de) 2011-01-15
EP1563071B1 (fr) 2008-09-17
JP4498144B2 (ja) 2010-07-07
DE60335676D1 (de) 2011-02-17
EP2239272A3 (fr) 2010-12-08
EP1925667A1 (fr) 2008-05-28
US20110027807A1 (en) 2011-02-03
JP5202550B2 (ja) 2013-06-05

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