FR2845686B1 - Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant - Google Patents

Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Info

Publication number
FR2845686B1
FR2845686B1 FR0212584A FR0212584A FR2845686B1 FR 2845686 B1 FR2845686 B1 FR 2845686B1 FR 0212584 A FR0212584 A FR 0212584A FR 0212584 A FR0212584 A FR 0212584A FR 2845686 B1 FR2845686 B1 FR 2845686B1
Authority
FR
France
Prior art keywords
heparin
activity
hexasaccharide
preparation
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0212584A
Other languages
English (en)
French (fr)
Other versions
FR2845686A1 (fr
Inventor
Vesna Biberovic
Luc Grondard
Pierre Mourier
Christian Viskov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0212584A priority Critical patent/FR2845686B1/fr
Priority to UAA200504331A priority patent/UA81925C2/uk
Priority to GT200300181A priority patent/GT200300181A/es
Priority to NI200300087A priority patent/NI200300087A/es
Priority to SV2003001626A priority patent/SV2004001626A/es
Priority to PA20038584201A priority patent/PA8584201A1/es
Priority to PE2003001005A priority patent/PE20040507A1/es
Priority to BR0315149-2A priority patent/BR0315149A/pt
Priority to SI200332145T priority patent/SI1556414T1/sl
Priority to MXPA05003321A priority patent/MXPA05003321A/es
Priority to CN201010147549A priority patent/CN101812190A/zh
Priority to ES03807882T priority patent/ES2383597T3/es
Priority to DK03807882.0T priority patent/DK1556414T3/da
Priority to CN201010147528A priority patent/CN101812189A/zh
Priority to ARP030103661A priority patent/AR041555A1/es
Priority to KR1020057006186A priority patent/KR101104107B1/ko
Priority to NZ539229A priority patent/NZ539229A/en
Priority to CN201010147509A priority patent/CN101810637A/zh
Priority to OA1200500102A priority patent/OA12940A/fr
Priority to CNA2003801009925A priority patent/CN1798771A/zh
Priority to EP03807882A priority patent/EP1556414B1/fr
Priority to HN2003000312A priority patent/HN2003000312A/es
Priority to AU2003300161A priority patent/AU2003300161B2/en
Priority to CN201010147539A priority patent/CN101812139A/zh
Priority to PT03807882T priority patent/PT1556414E/pt
Priority to RU2005113987/04A priority patent/RU2332424C2/ru
Priority to CA2501546A priority patent/CA2501546C/fr
Priority to PCT/FR2003/002960 priority patent/WO2004033503A1/fr
Priority to AT03807882T priority patent/ATE548393T1/de
Priority to YUP-2005/0274A priority patent/RS20050274A/sr
Priority to US10/680,934 priority patent/US20040171819A1/en
Priority to JP2004542566A priority patent/JP5021898B2/ja
Priority to CN201010120370A priority patent/CN101817940A/zh
Priority to MYPI20033852A priority patent/MY142376A/en
Priority to TW092128028A priority patent/TWI332010B/zh
Priority to UY28016A priority patent/UY28016A1/es
Publication of FR2845686A1 publication Critical patent/FR2845686A1/fr
Priority to MA28192A priority patent/MA27398A1/fr
Priority to IL167868A priority patent/IL167868A/en
Priority to ZA200502787A priority patent/ZA200502787B/en
Priority to TNP2005000101A priority patent/TNSN05101A1/fr
Priority to EC2005005722A priority patent/ECSP055722A/es
Priority to NO20052170A priority patent/NO20052170L/no
Priority to US11/882,607 priority patent/US8003623B2/en
Priority to US13/103,960 priority patent/US8071570B2/en
Priority to US13/105,528 priority patent/US20110212915A1/en
Priority to JP2011231218A priority patent/JP5389140B2/ja
Priority to CY20121100489T priority patent/CY1112808T1/el
Application granted granted Critical
Publication of FR2845686B1 publication Critical patent/FR2845686B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
FR0212584A 2002-10-10 2002-10-10 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant Expired - Fee Related FR2845686B1 (fr)

Priority Applications (47)

Application Number Priority Date Filing Date Title
FR0212584A FR2845686B1 (fr) 2002-10-10 2002-10-10 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
UAA200504331A UA81925C2 (uk) 2002-10-10 2003-08-10 Суміш сульфатованих олігосахаридів - похідних гепарину, спосіб їх приготування та фармацевтична композиція
GT200300181A GT200300181A (es) 2002-10-10 2003-08-26 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
NI200300087A NI200300087A (es) 2002-10-10 2003-09-18 Mezclas de polisacáridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen.
SV2003001626A SV2004001626A (es) 2002-10-10 2003-09-24 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
PA20038584201A PA8584201A1 (es) 2002-10-10 2003-10-01 Mezcla de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
PE2003001005A PE20040507A1 (es) 2002-10-10 2003-10-06 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
BR0315149-2A BR0315149A (pt) 2002-10-10 2003-10-08 Misturas de polissacarìdeos derivados de heparina, sua preparação e as composições farmacêuticas que as contêm
SI200332145T SI1556414T1 (sl) 2002-10-10 2003-10-08 Zmesi oligosaharidov, izvedenih iz heparina, njihova priprava in farmacevtski sestavki, ki jih vsebujejo
MXPA05003321A MXPA05003321A (es) 2002-10-10 2003-10-08 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen.
CN201010147549A CN101812190A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
ES03807882T ES2383597T3 (es) 2002-10-10 2003-10-08 Mezclas de oligosacáridos derivados de heparina, su preparación y las composiciones farmacéuticas que las contienen
DK03807882.0T DK1556414T3 (da) 2002-10-10 2003-10-08 Blandinger af heparinafledte oligosaccharider, fremstilling deraf og farmaceutisk præparater, der indeholder dem
CN201010147528A CN101812189A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
ARP030103661A AR041555A1 (es) 2002-10-10 2003-10-08 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
KR1020057006186A KR101104107B1 (ko) 2002-10-10 2003-10-08 헤파린으로부터 유도된 다당류의 혼합물, 이의 제조방법 및이를 함유하는 약제학적 조성물
NZ539229A NZ539229A (en) 2002-10-10 2003-10-08 Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
CN201010147509A CN101810637A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
OA1200500102A OA12940A (fr) 2002-10-10 2003-10-08 Mélanges de polysaccharides dérivés d'héparine, leur préparation et les compositions pharmaceutiquesles contenant.
CNA2003801009925A CN1798771A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
EP03807882A EP1556414B1 (fr) 2002-10-10 2003-10-08 Melanges d'oligosaccharides derives d'heparine, leur preparation et compositions pharmaceutiques les contenant
HN2003000312A HN2003000312A (es) 2002-10-10 2003-10-08 Mezclas de polisacaridos derivados de heparina, supreparacion y las composiciones farmaceuticas que las contienen
AU2003300161A AU2003300161B2 (en) 2002-10-10 2003-10-08 Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
CN201010147539A CN101812139A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
PT03807882T PT1556414E (pt) 2002-10-10 2003-10-08 Misturas de oligossacáridos derivados de heparina, sua preparação e composições farmacêuticas que as contêm
RU2005113987/04A RU2332424C2 (ru) 2002-10-10 2003-10-08 Смесь полисахаридов, являющихся производными гепарина, их получение и фармацевтические композиции, их содержащие
CA2501546A CA2501546C (fr) 2002-10-10 2003-10-08 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2003/002960 WO2004033503A1 (fr) 2002-10-10 2003-10-08 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
AT03807882T ATE548393T1 (de) 2002-10-10 2003-10-08 Mischungen von aus heparin hergestellten oligosacchariden, deren herstellung und diese enthaltenden pharmazeutischen zusammensetzungen
YUP-2005/0274A RS20050274A (sr) 2002-10-10 2003-10-08 Smeše polisaharida izvedene od heparina, njihovo dobijanje i farmaceutski preparati koji ih sadrže
US10/680,934 US20040171819A1 (en) 2002-10-10 2003-10-08 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
JP2004542566A JP5021898B2 (ja) 2002-10-10 2003-10-08 ヘパリン誘導多糖類混合物、その製造およびそれを含有する医薬組成物
CN201010120370A CN101817940A (zh) 2002-10-10 2003-10-08 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物
MYPI20033852A MY142376A (en) 2002-10-10 2003-10-09 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
TW092128028A TWI332010B (en) 2002-10-10 2003-10-09 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
UY28016A UY28016A1 (es) 2002-10-10 2003-10-10 Mezclas de polisacáridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen.
MA28192A MA27398A1 (fr) 2002-10-10 2005-04-01 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
IL167868A IL167868A (en) 2002-10-10 2005-04-05 Heparin derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing them
ZA200502787A ZA200502787B (en) 2002-10-10 2005-04-06 Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same.
TNP2005000101A TNSN05101A1 (fr) 2002-10-10 2005-04-07 Melanges de polysaccharides derives d'heparine leur preparation et les compositions pharmaceutiques les contenant
EC2005005722A ECSP055722A (es) 2002-10-10 2005-04-08 Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
NO20052170A NO20052170L (no) 2002-10-10 2005-05-03 Heparin-deriverte polysakkaridblandinger, fremstilling derav og farmasoytiske sammensetninger inneholdende det samme
US11/882,607 US8003623B2 (en) 2002-10-10 2007-08-02 Mixtures of sulfated oligosaccharides
US13/103,960 US8071570B2 (en) 2002-10-10 2011-05-09 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US13/105,528 US20110212915A1 (en) 2002-10-10 2011-05-11 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
JP2011231218A JP5389140B2 (ja) 2002-10-10 2011-10-21 ヘパリン誘導多糖類混合物、その製造およびそれを含有する医薬組成物
CY20121100489T CY1112808T1 (el) 2002-10-10 2012-05-30 Μειγματα ολιγοσακχαριτων προερχομενων απο την ηπαρινη, η παρασκευη τους και φαρμακευτικες συνθεσεις που τα περιεχουν

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0212584A FR2845686B1 (fr) 2002-10-10 2002-10-10 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2845686A1 FR2845686A1 (fr) 2004-04-16
FR2845686B1 true FR2845686B1 (fr) 2013-08-30

Family

ID=32039597

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0212584A Expired - Fee Related FR2845686B1 (fr) 2002-10-10 2002-10-10 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Country Status (35)

Country Link
EP (1) EP1556414B1 (enExample)
JP (2) JP5021898B2 (enExample)
CN (6) CN101810637A (enExample)
AT (1) ATE548393T1 (enExample)
AU (1) AU2003300161B2 (enExample)
BR (1) BR0315149A (enExample)
CA (1) CA2501546C (enExample)
CY (1) CY1112808T1 (enExample)
DK (1) DK1556414T3 (enExample)
EC (1) ECSP055722A (enExample)
ES (1) ES2383597T3 (enExample)
FR (1) FR2845686B1 (enExample)
GT (1) GT200300181A (enExample)
HN (1) HN2003000312A (enExample)
IL (1) IL167868A (enExample)
MA (1) MA27398A1 (enExample)
MX (1) MXPA05003321A (enExample)
MY (1) MY142376A (enExample)
NI (1) NI200300087A (enExample)
NO (1) NO20052170L (enExample)
NZ (1) NZ539229A (enExample)
OA (1) OA12940A (enExample)
PA (1) PA8584201A1 (enExample)
PE (1) PE20040507A1 (enExample)
PT (1) PT1556414E (enExample)
RS (1) RS20050274A (enExample)
RU (1) RU2332424C2 (enExample)
SI (1) SI1556414T1 (enExample)
SV (1) SV2004001626A (enExample)
TN (1) TNSN05101A1 (enExample)
TW (1) TWI332010B (enExample)
UA (1) UA81925C2 (enExample)
UY (1) UY28016A1 (enExample)
WO (1) WO2004033503A1 (enExample)
ZA (1) ZA200502787B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP2447285A3 (en) * 2006-05-25 2013-01-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
WO2008068854A1 (ja) 2006-12-05 2008-06-12 Glycoscience Laboratories, Inc. 変形性関節症の治療剤
WO2010087207A1 (ja) 2009-02-02 2010-08-05 大塚化学株式会社 低分子量多硫酸化ヒアルロン酸誘導体及びこれを含有する医薬
EP2233145A1 (en) 2009-03-19 2010-09-29 Sanofi-Aventis A dose of AVE5026 for the treatment of venous thromboembolism in patients with severe renal impairment
EP2399591A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399592A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399590A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399593A1 (en) 2010-06-28 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
JP2012046511A (ja) * 2010-07-30 2012-03-08 Otsuka Chem Co Ltd 低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬
DK3144325T3 (da) * 2010-09-14 2021-01-25 Univ Miyazaki Heparin med høj renhed og fremstillingsfremgangsmåde dertil
WO2012055843A1 (en) 2010-10-28 2012-05-03 Aventis Pharma S.A. Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2446891A1 (en) 2010-10-28 2012-05-02 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012072799A1 (en) 2010-12-02 2012-06-07 Aventis Pharma S.A. New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
AR085961A1 (es) 2011-04-11 2013-11-06 Sanofi Sa Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
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