CN101810637A - 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 - Google Patents
由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 Download PDFInfo
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- CN101810637A CN101810637A CN201010147509A CN201010147509A CN101810637A CN 101810637 A CN101810637 A CN 101810637A CN 201010147509 A CN201010147509 A CN 201010147509A CN 201010147509 A CN201010147509 A CN 201010147509A CN 101810637 A CN101810637 A CN 101810637A
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- heparin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212584A FR2845686B1 (fr) | 2002-10-10 | 2002-10-10 | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR0212584 | 2002-10-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNA2003801009925A Division CN1798771A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
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| CN201010147549A Pending CN101812190A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CNA2003801009925A Pending CN1798771A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010147539A Pending CN101812139A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010147528A Pending CN101812189A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010120370A Pending CN101817940A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
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| CN201010147549A Pending CN101812190A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CNA2003801009925A Pending CN1798771A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010147539A Pending CN101812139A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010147528A Pending CN101812189A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
| CN201010120370A Pending CN101817940A (zh) | 2002-10-10 | 2003-10-08 | 由肝素衍生的多糖混合物、其制备方法以及含有它们的药物组合物 |
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR2857971B1 (fr) * | 2003-07-24 | 2005-08-26 | Aventis Pharma Sa | Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| EP2447285A3 (en) * | 2006-05-25 | 2013-01-16 | Momenta Pharmaceuticals, Inc. | Low molecular weight heparin composition and uses thereof |
| WO2008068854A1 (ja) | 2006-12-05 | 2008-06-12 | Glycoscience Laboratories, Inc. | 変形性関節症の治療剤 |
| WO2010087207A1 (ja) | 2009-02-02 | 2010-08-05 | 大塚化学株式会社 | 低分子量多硫酸化ヒアルロン酸誘導体及びこれを含有する医薬 |
| EP2233145A1 (en) | 2009-03-19 | 2010-09-29 | Sanofi-Aventis | A dose of AVE5026 for the treatment of venous thromboembolism in patients with severe renal impairment |
| EP2399591A1 (en) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery |
| EP2399592A1 (en) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings |
| EP2399590A1 (en) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery |
| EP2399593A1 (en) | 2010-06-28 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile |
| JP2012046511A (ja) * | 2010-07-30 | 2012-03-08 | Otsuka Chem Co Ltd | 低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬 |
| DK3144325T3 (da) * | 2010-09-14 | 2021-01-25 | Univ Miyazaki | Heparin med høj renhed og fremstillingsfremgangsmåde dertil |
| WO2012055843A1 (en) | 2010-10-28 | 2012-05-03 | Aventis Pharma S.A. | Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery |
| EP2446891A1 (en) | 2010-10-28 | 2012-05-02 | Aventis Pharma S.A. | Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings |
| WO2012072799A1 (en) | 2010-12-02 | 2012-06-07 | Aventis Pharma S.A. | New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample |
| AR085961A1 (es) | 2011-04-11 | 2013-11-06 | Sanofi Sa | Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen |
| EP2548561A1 (en) | 2011-07-22 | 2013-01-23 | Aventis Pharma S.A. | Semuloparin for improving the survival of patients with locally advanced cancer |
| WO2013044793A1 (zh) * | 2011-09-26 | 2013-04-04 | Xu Meiying | 一种高纯度肝素苄酯盐及其制法和应用 |
| CN102633908A (zh) * | 2012-05-02 | 2012-08-15 | 雷晓刚 | 一种高品质超低分子量肝素的制备方法 |
| ES2445494B1 (es) * | 2012-08-02 | 2015-03-06 | Rovi Lab Farmaceut Sa | Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular |
| US9873712B2 (en) * | 2014-10-03 | 2018-01-23 | Amphastar Pharmaceuticals, Inc. | Method of purifying idraparinux sodium |
| US20190002596A1 (en) * | 2015-12-30 | 2019-01-03 | Shenzhen Hepalink Pharmaceutical Group Co., Ltd. | Sulfated heparin oligosaccharide and preparation method and application thereof |
| CZ308106B6 (cs) * | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| CN110917208B (zh) * | 2019-12-27 | 2021-02-12 | 浙江医院 | 硫酸化甘露葡萄糖醛酸六糖在防治动脉粥样硬化中的应用 |
| CN117534776A (zh) * | 2023-09-26 | 2024-02-09 | 南京健友生化制药股份有限公司 | 一种依诺酯化反应液的除杂方法 |
Family Cites Families (11)
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|---|---|---|---|---|
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| FR2482611B1 (fr) * | 1980-05-14 | 1986-03-07 | Pharmindustrie | Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments |
| FR2504928A1 (fr) * | 1981-04-29 | 1982-11-05 | Choay Sa | Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| FR2584606A1 (fr) * | 1985-07-12 | 1987-01-16 | Dropic | Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif |
| FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
| ES2161615B1 (es) * | 1999-07-23 | 2003-03-16 | Rovi Lab Farmaceut Sa | Composiciones de heparinas de muy bajo peso molecular. |
| JP4897991B2 (ja) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | 超低分子量ヘパリン組成物 |
| FR2807043B1 (fr) * | 2000-03-28 | 2002-11-22 | Aventis Pharma Sa | Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation |
| FR2811992B1 (fr) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
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- 2003-10-08 MX MXPA05003321A patent/MXPA05003321A/es active IP Right Grant
- 2003-10-08 OA OA1200500102A patent/OA12940A/fr unknown
- 2003-10-08 WO PCT/FR2003/002960 patent/WO2004033503A1/fr not_active Ceased
- 2003-10-08 CN CNA2003801009925A patent/CN1798771A/zh active Pending
- 2003-10-08 CN CN201010147539A patent/CN101812139A/zh active Pending
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