FR2793794B1 - Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation - Google Patents

Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Info

Publication number
FR2793794B1
FR2793794B1 FR9906456A FR9906456A FR2793794B1 FR 2793794 B1 FR2793794 B1 FR 2793794B1 FR 9906456 A FR9906456 A FR 9906456A FR 9906456 A FR9906456 A FR 9906456A FR 2793794 B1 FR2793794 B1 FR 2793794B1
Authority
FR
France
Prior art keywords
medicaments
application
pharmaceutical compositions
preparation process
new use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9906456A
Other languages
English (en)
French (fr)
Other versions
FR2793794A1 (fr
Inventor
Jean Luc Haesslein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel
Priority to FR9906456A priority Critical patent/FR2793794B1/fr
Priority to TW089108817A priority patent/TWI284130B/zh
Priority to AT00929625T priority patent/ATE370951T1/de
Priority to YU86601A priority patent/YU86601A/sh
Priority to US09/979,389 priority patent/US7122669B1/en
Priority to SK1672-2001A priority patent/SK16722001A3/sk
Priority to KR1020017014800A priority patent/KR100707895B1/ko
Priority to DK00929625T priority patent/DK1183256T3/da
Priority to MXPA01011834A priority patent/MXPA01011834A/es
Priority to ES00929625T priority patent/ES2290033T3/es
Priority to EA200101224A priority patent/EA005072B1/ru
Priority to PL00352293A priority patent/PL352293A1/xx
Priority to AU47645/00A priority patent/AU4764500A/en
Priority to PCT/FR2000/001335 priority patent/WO2000071543A1/fr
Priority to PT00929625T priority patent/PT1183256E/pt
Priority to HU0201649A priority patent/HUP0201649A3/hu
Priority to BR0011282-8A priority patent/BR0011282A/pt
Priority to JP2000619799A priority patent/JP2003500407A/ja
Priority to UA2001128864A priority patent/UA68441C2/uk
Priority to EP00929625A priority patent/EP1183256B1/fr
Priority to TR2001/03349T priority patent/TR200103349T2/xx
Priority to SI200030967T priority patent/SI1183256T1/sl
Priority to CA002374714A priority patent/CA2374714A1/fr
Priority to CNB008106509A priority patent/CN1298719C/zh
Priority to DZ003166A priority patent/DZ3166A1/xx
Priority to DE60036102T priority patent/DE60036102T2/de
Priority to CZ20014163A priority patent/CZ20014163A3/cs
Priority to NZ515556A priority patent/NZ515556A/en
Priority to APAP/P/2001/002355A priority patent/AP1477A/en
Priority to IL14644100A priority patent/IL146441A0/xx
Priority to ARP000102428A priority patent/AR035317A1/es
Publication of FR2793794A1 publication Critical patent/FR2793794A1/fr
Application granted granted Critical
Publication of FR2793794B1 publication Critical patent/FR2793794B1/fr
Priority to MA26410A priority patent/MA26791A1/fr
Priority to NO20015659A priority patent/NO20015659L/no
Priority to ZA200109602A priority patent/ZA200109602B/xx
Priority to US11/006,013 priority patent/US7208598B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9906456A 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation Expired - Fee Related FR2793794B1 (fr)

Priority Applications (35)

Application Number Priority Date Filing Date Title
FR9906456A FR2793794B1 (fr) 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
TW089108817A TWI284130B (en) 1999-05-21 2000-05-09 New derivatives of purine, their preparation process, their use as medicaments, pharmaceutical compositions and new use
TR2001/03349T TR200103349T2 (tr) 1999-05-21 2000-05-18 Purin türevleri, hazırlama usulü ve bunları içeren ispençiyari bileşimleri.
US09/979,389 US7122669B1 (en) 1999-05-21 2000-05-18 Purine derivatives, preparation method and pharmaceutical compositions containing same
SK1672-2001A SK16722001A3 (sk) 1999-05-21 2000-05-18 Deriváty purínu, spôsob ich prípravy a farmaceutické kompozície tieto deriváty obsahujúce
KR1020017014800A KR100707895B1 (ko) 1999-05-21 2000-05-18 푸린 유도체, 그의 제조 방법 및 이를 함유하는 제약 조성물
DK00929625T DK1183256T3 (da) 1999-05-21 2000-05-18 Puridinderivater, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
MXPA01011834A MXPA01011834A (es) 1999-05-21 2000-05-18 Derivados de purina, metodo de preparacion y composiciones farmaceuticas que los contienen.
ES00929625T ES2290033T3 (es) 1999-05-21 2000-05-18 Derivados de la purina, su procedimiento de preparacion, y composiciones farmaceuticas que los contienen.
EA200101224A EA005072B1 (ru) 1999-05-21 2000-05-18 Производные пурина, способ их получения и содержащие их фармацевтические композиции
CA002374714A CA2374714A1 (fr) 1999-05-21 2000-05-18 Derives de la purine, leur procede de preparation, et compositions pharmaceutiques les contenant
AU47645/00A AU4764500A (en) 1999-05-21 2000-05-18 Purine derivatives, preparation method and pharmaceutical compositions containing same
PCT/FR2000/001335 WO2000071543A1 (fr) 1999-05-21 2000-05-18 Derives de la purine, leur procede de preparation, et compositions pharmaceutiques les contenant
PT00929625T PT1183256E (pt) 1999-05-21 2000-05-18 Derivados de purina, processo de preparação e composições farmacêuticas que os contêm
HU0201649A HUP0201649A3 (en) 1999-05-21 2000-05-18 Purine derivatives, preparation method and pharmaceutical compositions containing same
BR0011282-8A BR0011282A (pt) 1999-05-21 2000-05-18 Derivados da purina, seu processo de preparo e composiçoes farmacêuticas que as contêm
JP2000619799A JP2003500407A (ja) 1999-05-21 2000-05-18 プリン誘導体、それらの製造方法及びそれらを含有する製薬組成物
UA2001128864A UA68441C2 (en) 1999-05-21 2000-05-18 Purine derivatives, method for synthesis and pharmaceutical compositions
AT00929625T ATE370951T1 (de) 1999-05-21 2000-05-18 Purinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
SI200030967T SI1183256T1 (sl) 1999-05-21 2000-05-18 Derivati purina, postopek za njihovo pripravo in farmacevtski sestavki,ki jih vsebujejo
YU86601A YU86601A (sh) 1999-05-21 2000-05-18 Derivati purina, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
PL00352293A PL352293A1 (en) 1999-05-21 2000-05-18 Derivatives of purine, method of making same and pharmaceutical compositions containing these derivatives
CNB008106509A CN1298719C (zh) 1999-05-21 2000-05-18 嘌呤衍生物、其制备方法和含有它们的药物组合物
DZ003166A DZ3166A1 (fr) 1999-05-21 2000-05-18 Dérivés de la purine, leur procédé de préparation,et compositions pharmaceutiques les contenant.
DE60036102T DE60036102T2 (de) 1999-05-21 2000-05-18 Purinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
CZ20014163A CZ20014163A3 (cs) 1999-05-21 2000-05-18 Deriváty purinu, způsob jejich přípravy a farmaceutické kompozice tyto deriváty obsahující
NZ515556A NZ515556A (en) 1999-05-21 2000-05-18 Purine derivatives, preparation method and pharmaceutical compositions containing same
APAP/P/2001/002355A AP1477A (en) 1999-05-21 2000-05-18 Derivatives of purine, their preparation process and pharmaceutical compositions containing them.
IL14644100A IL146441A0 (en) 1999-05-21 2000-05-18 Purine derivatives, preparation method and pharmaceutical compositions containing same
EP00929625A EP1183256B1 (fr) 1999-05-21 2000-05-18 Derives de la purine, leur procede de preparation, et compositions pharmaceutiques les contenant
ARP000102428A AR035317A1 (es) 1999-05-21 2000-05-19 Derivados de purina, su procedimiento de preparacion, medicamentos, composiciones farmaceuticas y utilizacion de compuestos para la preparacion de medicamentos
MA26410A MA26791A1 (fr) 1999-05-21 2001-11-15 Derives de la purine, leur procede de preparation, et compositions pharmaceutiques les contenant.
NO20015659A NO20015659L (no) 1999-05-21 2001-11-20 Purinderivater, fremstillingsmetode og farmasöytiske preparater inneholdende disse
ZA200109602A ZA200109602B (en) 1999-05-21 2001-11-21 Purine derivatives, preparation method and pharmaceutical compositions containing same.
US11/006,013 US7208598B2 (en) 1999-05-21 2004-12-07 Derivatives of purine, their preparation process and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906456A FR2793794B1 (fr) 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Publications (2)

Publication Number Publication Date
FR2793794A1 FR2793794A1 (fr) 2000-11-24
FR2793794B1 true FR2793794B1 (fr) 2001-07-27

Family

ID=9545846

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9906456A Expired - Fee Related FR2793794B1 (fr) 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Country Status (33)

Country Link
US (2) US7122669B1 (enExample)
EP (1) EP1183256B1 (enExample)
JP (1) JP2003500407A (enExample)
KR (1) KR100707895B1 (enExample)
CN (1) CN1298719C (enExample)
AP (1) AP1477A (enExample)
AR (1) AR035317A1 (enExample)
AT (1) ATE370951T1 (enExample)
AU (1) AU4764500A (enExample)
BR (1) BR0011282A (enExample)
CA (1) CA2374714A1 (enExample)
CZ (1) CZ20014163A3 (enExample)
DE (1) DE60036102T2 (enExample)
DK (1) DK1183256T3 (enExample)
DZ (1) DZ3166A1 (enExample)
EA (1) EA005072B1 (enExample)
ES (1) ES2290033T3 (enExample)
FR (1) FR2793794B1 (enExample)
HU (1) HUP0201649A3 (enExample)
IL (1) IL146441A0 (enExample)
MA (1) MA26791A1 (enExample)
MX (1) MXPA01011834A (enExample)
NO (1) NO20015659L (enExample)
NZ (1) NZ515556A (enExample)
PL (1) PL352293A1 (enExample)
PT (1) PT1183256E (enExample)
SK (1) SK16722001A3 (enExample)
TR (1) TR200103349T2 (enExample)
TW (1) TWI284130B (enExample)
UA (1) UA68441C2 (enExample)
WO (1) WO2000071543A1 (enExample)
YU (1) YU86601A (enExample)
ZA (1) ZA200109602B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
EP1377579B1 (en) * 2000-10-31 2009-03-25 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
CA2463563A1 (en) * 2001-10-12 2003-04-17 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
AU2003301407B2 (en) * 2002-10-15 2010-04-22 Irm Llc Compositions and methods for inducing osteogenesis
FR2851248B1 (fr) * 2003-02-18 2005-04-08 Aventis Pharma Sa Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
WO2005047524A2 (en) 2003-11-10 2005-05-26 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
AU2005231440B9 (en) * 2004-04-02 2012-02-23 Dogwood Pharmaceuticals, Inc. Selective antagonists of A2A adenosine receptors
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
WO2012142029A2 (en) 2011-04-10 2012-10-18 Florida A&M University Serms for the treatment of estrogen receptor-mediated disorders
WO2015162518A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
EP4086257A1 (en) * 2016-09-30 2022-11-09 SRI International Dual clk/cdk1 inhibitors for cancer treatment
CZ308029B6 (cs) 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
AR131380A1 (es) 2022-12-16 2025-03-12 Astrazeneca Ab Purinas 2,6,9-trisustituidas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
EP0841810B1 (en) * 1991-12-05 2000-06-21 Texas Instruments Incorporated Method to improve a video signal
CA2084222C (en) * 1991-12-06 2004-04-06 David R. Borcherding Novel trans cyclopentanyl purine analogs useful as immunosuppressants
CN1066147C (zh) * 1995-11-01 2001-05-23 诺瓦提斯公司 嘌呤衍生物及其制备方法
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
WO1998016528A1 (en) * 1996-10-11 1998-04-23 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
WO1999007705A1 (en) * 1997-08-07 1999-02-18 The Regents Of The University Of California Purine inhibitor of protein kinases, g proteins and polymerases
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion

Also Published As

Publication number Publication date
EA200101224A1 (ru) 2002-10-31
NZ515556A (en) 2003-08-29
HUP0201649A3 (en) 2003-01-28
US7208598B2 (en) 2007-04-24
UA68441C2 (en) 2004-08-16
EA005072B1 (ru) 2004-10-28
YU86601A (sh) 2005-07-19
ATE370951T1 (de) 2007-09-15
TR200103349T2 (tr) 2002-05-21
EP1183256A1 (fr) 2002-03-06
DE60036102T2 (de) 2008-05-15
JP2003500407A (ja) 2003-01-07
ES2290033T3 (es) 2008-02-16
IL146441A0 (en) 2002-07-25
TWI284130B (en) 2007-07-21
DE60036102D1 (de) 2007-10-04
US20050187228A1 (en) 2005-08-25
BR0011282A (pt) 2002-02-26
AP2001002355A0 (en) 2001-12-31
CN1298719C (zh) 2007-02-07
MXPA01011834A (es) 2002-04-17
NO20015659D0 (no) 2001-11-20
PL352293A1 (en) 2003-08-11
ZA200109602B (en) 2003-01-29
NO20015659L (no) 2002-01-18
AP1477A (en) 2005-10-19
US7122669B1 (en) 2006-10-17
CA2374714A1 (fr) 2000-11-30
WO2000071543A1 (fr) 2000-11-30
FR2793794A1 (fr) 2000-11-24
HUP0201649A2 (en) 2002-08-28
MA26791A1 (fr) 2004-12-20
CZ20014163A3 (cs) 2002-10-16
KR20010113975A (ko) 2001-12-28
AU4764500A (en) 2000-12-12
KR100707895B1 (ko) 2007-04-17
PT1183256E (pt) 2007-11-13
CN1361780A (zh) 2002-07-31
DK1183256T3 (da) 2007-12-03
EP1183256B1 (fr) 2007-08-22
SK16722001A3 (sk) 2003-01-09
AR035317A1 (es) 2004-05-12
DZ3166A1 (fr) 2000-11-30

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