FR2791678B1 - Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique - Google Patents

Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique

Info

Publication number
FR2791678B1
FR2791678B1 FR9903934A FR9903934A FR2791678B1 FR 2791678 B1 FR2791678 B1 FR 2791678B1 FR 9903934 A FR9903934 A FR 9903934A FR 9903934 A FR9903934 A FR 9903934A FR 2791678 B1 FR2791678 B1 FR 2791678B1
Authority
FR
France
Prior art keywords
nonane
diazabicyclo
carboxylates
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9903934A
Other languages
English (en)
French (fr)
Other versions
FR2791678A1 (fr
Inventor
Alistair Lochead
Samir Jegham
Alain Nedelec
Thierry Gallet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9903934A priority Critical patent/FR2791678B1/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to SI200030076T priority patent/SI1165559T1/xx
Priority to JP2000608013A priority patent/JP4500454B2/ja
Priority to AT00911011T priority patent/ATE232865T1/de
Priority to EP00911011A priority patent/EP1165559B1/fr
Priority to US09/937,045 priority patent/US6987106B1/en
Priority to ES00911011T priority patent/ES2192520T3/es
Priority to AU33018/00A priority patent/AU3301800A/en
Priority to PCT/FR2000/000697 priority patent/WO2000058311A1/fr
Priority to DK00911011T priority patent/DK1165559T3/da
Priority to DE60001451T priority patent/DE60001451T2/de
Priority to TW089105707A priority patent/TWI221843B/zh
Priority to ARP000101379A priority patent/AR023188A1/es
Priority to CO00022162A priority patent/CO5180557A1/es
Priority to UY26082A priority patent/UY26082A1/es
Priority to PE2000000274A priority patent/PE20001600A1/es
Publication of FR2791678A1 publication Critical patent/FR2791678A1/fr
Application granted granted Critical
Publication of FR2791678B1 publication Critical patent/FR2791678B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9903934A 1999-03-30 1999-03-30 Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique Expired - Fee Related FR2791678B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR9903934A FR2791678B1 (fr) 1999-03-30 1999-03-30 Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique
DE60001451T DE60001451T2 (de) 1999-03-30 2000-03-21 1,4-diazabicyclo[3.2.2]nonan-4-carboxylat und carboxamidderivate, ihre herstellung und therapeutische verwendung
AT00911011T ATE232865T1 (de) 1999-03-30 2000-03-21 1,4-diazabicyclo(3.2.2)nonan-4-carboxylat und carboxamidderivate, ihre herstellung und therapeutische verwendung
EP00911011A EP1165559B1 (fr) 1999-03-30 2000-03-21 Derives de 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates et carboxamides, leur preparation et leur application en therapeutique
US09/937,045 US6987106B1 (en) 1999-03-30 2000-03-21 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamide derivates, production and use thereof in therapeutics
ES00911011T ES2192520T3 (es) 1999-03-30 2000-03-21 Composicion farmaceutica.
AU33018/00A AU3301800A (en) 1999-03-30 2000-03-21 1,4-diazabicyclo(3.2.2)nonane-4-carboxylate and carboxamide derivatives, production and use thereof in therapeutics
PCT/FR2000/000697 WO2000058311A1 (fr) 1999-03-30 2000-03-21 Derives de 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates et carboxamides, leur preparation et leur application en therapeutique
SI200030076T SI1165559T1 (en) 1999-03-30 2000-03-21 1,4-diazabicyclo(3.2.2)nonane-4-carboxylate and carboxamide derivatives, production and use thereof in therapeutics
JP2000608013A JP4500454B2 (ja) 1999-03-30 2000-03-21 １，４−ジアザビシクロ［３．２．２］ノナン−４−カルボキシレートおよびカルボキサミド誘導体、治療におけるその製造ならびに使用
DK00911011T DK1165559T3 (da) 1999-03-30 2000-03-21 Derivater af 1,4-diazabicyclo[3.2.2]nonan-4-carboxylater og carboxamider, fremstilling heraf og anvendelse heraf inden for terapeutik
TW089105707A TWI221843B (en) 1999-03-30 2000-03-28 Derivatives 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamides, their preparation and their therapeutic application
ARP000101379A AR023188A1 (es) 1999-03-30 2000-03-28 Derivados de 1,4-diazabiciclo[3.2.2]nonan-4-carboxilatos y carboxamidas, su preparacion y su aplicacion en terapeutica
CO00022162A CO5180557A1 (es) 1999-03-30 2000-03-28 Derivados de 1,4-diazabiciclo[3.2.2]nonan-4-carboxilatos y carboxamidas y sus composiciones farmaceuticas .
UY26082A UY26082A1 (es) 1999-03-30 2000-03-28 Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
PE2000000274A PE20001600A1 (es) 1999-03-30 2000-03-30 Derivados de 1,4-diazabiciclo (3.3.2) nonan-4-carboxilatos y carboxamidas, su preparacion y su aplicacion en terapeutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903934A FR2791678B1 (fr) 1999-03-30 1999-03-30 Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2791678A1 FR2791678A1 (fr) 2000-10-06
FR2791678B1 true FR2791678B1 (fr) 2001-05-04

Family

ID=9543787

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9903934A Expired - Fee Related FR2791678B1 (fr) 1999-03-30 1999-03-30 Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique

Country Status (15)

Country Link
US (1) US6987106B1 (enExample)
EP (1) EP1165559B1 (enExample)
JP (1) JP4500454B2 (enExample)
AR (1) AR023188A1 (enExample)
AT (1) ATE232865T1 (enExample)
AU (1) AU3301800A (enExample)
CO (1) CO5180557A1 (enExample)
DE (1) DE60001451T2 (enExample)
DK (1) DK1165559T3 (enExample)
ES (1) ES2192520T3 (enExample)
FR (1) FR2791678B1 (enExample)
PE (1) PE20001600A1 (enExample)
TW (1) TWI221843B (enExample)
UY (1) UY26082A1 (enExample)
WO (1) WO2000058311A1 (enExample)

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US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
DE60216830T2 (de) * 2001-02-06 2007-06-14 Pfizer Products Inc., Groton Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
SE0202465D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
SE0202430D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
ES2405594T3 (es) 2002-09-25 2013-05-31 Memory Pharmaceuticals Corporation Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos
NZ540998A (en) 2003-02-27 2008-06-30 Neurosearch As Novel diazabicyclic aryl derivatives
TW200529860A (en) * 2003-12-22 2005-09-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
JP2007515480A (ja) * 2003-12-22 2007-06-14 アストラゼネカ・アクチエボラーグ ニコチン性アセチルコリンレセプターリガンド
EP1697378B1 (en) 2003-12-22 2007-11-21 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
US20080227772A1 (en) * 2004-02-04 2008-09-18 Neurosearch A/S Diazabicyclic Aryl Derivatives as Nicotinic Acetylcholine Receptor Ligands
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US7488737B2 (en) 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
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DE602005025902D1 (de) * 2004-10-15 2011-02-24 Neurosearch As Neue azabizyklische arylderivate und medizinische verwendung damit
RU2418797C2 (ru) 2004-12-22 2011-05-20 Мемори Фармасьютиклз Корпорейшн Лиганды никотинового рецептора альфа-7, их получение и применение
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
JP2009526776A (ja) * 2006-02-14 2009-07-23 ノイロサーチ アクティーゼルスカブ 新規なジアザビシクロアルカン誘導体及びその医療上の使用
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JP2009537598A (ja) 2006-05-23 2009-10-29 ノイロサーチ アクティーゼルスカブ 新規１，４−ジアザ−ビシクロ［３．２．２］ノナン誘導体及びそれらの医学的使用
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CN103221411B (zh) 2010-05-17 2016-05-11 富瑞姆制药公司 (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐单水合物的晶型
TWI634119B (zh) * 2011-03-18 2018-09-01 美商健臻公司 葡萄糖神經醯胺合成酶抑制劑
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
CN107188900B (zh) * 2017-05-27 2019-09-06 北京师范大学 α7烟碱型乙酰胆碱受体的配体化合物及其应用
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Publication number Publication date
EP1165559A1 (fr) 2002-01-02
DK1165559T3 (da) 2003-06-10
ATE232865T1 (de) 2003-03-15
AR023188A1 (es) 2002-09-04
UY26082A1 (es) 2000-10-31
PE20001600A1 (es) 2001-04-01
TWI221843B (en) 2004-10-11
DE60001451D1 (de) 2003-03-27
DE60001451T2 (de) 2004-01-15
JP4500454B2 (ja) 2010-07-14
EP1165559B1 (fr) 2003-02-19
AU3301800A (en) 2000-10-16
JP2002540208A (ja) 2002-11-26
US6987106B1 (en) 2006-01-17
ES2192520T3 (es) 2003-10-16
FR2791678A1 (fr) 2000-10-06
CO5180557A1 (es) 2002-07-30
WO2000058311A1 (fr) 2000-10-05

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