FR2756563B1 - Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique - Google Patents

Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique

Info

Publication number
FR2756563B1
FR2756563B1 FR9614847A FR9614847A FR2756563B1 FR 2756563 B1 FR2756563 B1 FR 2756563B1 FR 9614847 A FR9614847 A FR 9614847A FR 9614847 A FR9614847 A FR 9614847A FR 2756563 B1 FR2756563 B1 FR 2756563B1
Authority
FR
France
Prior art keywords
diazabicyclo
oct
preparation
methyl benzoate
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9614847A
Other languages
English (en)
Other versions
FR2756563A1 (fr
Inventor
Alistair Lochead
Samir Jegham
Alain Nedelec
Axelle Solignac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9614847A priority Critical patent/FR2756563B1/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to CN97180353A priority patent/CN1239962A/zh
Priority to CZ991937A priority patent/CZ193799A3/cs
Priority to EP97948976A priority patent/EP0942910A1/fr
Priority to EEP199900218A priority patent/EE9900218A/xx
Priority to PCT/FR1997/002174 priority patent/WO1998024790A1/fr
Priority to IL12992797A priority patent/IL129927A0/xx
Priority to TR1999/01068T priority patent/TR199901068T2/xx
Priority to SK741-99A priority patent/SK74199A3/sk
Priority to NZ336044A priority patent/NZ336044A/xx
Priority to CA002271072A priority patent/CA2271072A1/fr
Priority to KR1019997004915A priority patent/KR20000069283A/ko
Priority to US09/319,413 priority patent/US6057321A/en
Priority to AU76245/98A priority patent/AU7624598A/en
Priority to HU9904206A priority patent/HUP9904206A3/hu
Priority to JP52527298A priority patent/JP2001504855A/ja
Priority to BR9714215-8A priority patent/BR9714215A/pt
Publication of FR2756563A1 publication Critical patent/FR2756563A1/fr
Publication of FR2756563B1 publication Critical patent/FR2756563B1/fr
Application granted granted Critical
Priority to BG103432A priority patent/BG103432A/xx
Priority to NO992676A priority patent/NO992676L/no
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9614847A 1996-12-04 1996-12-04 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique Expired - Fee Related FR2756563B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR9614847A FR2756563B1 (fr) 1996-12-04 1996-12-04 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique
US09/319,413 US6057321A (en) 1996-12-04 1997-12-02 1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their preparation and therapeutic application
KR1019997004915A KR20000069283A (ko) 1996-12-04 1997-12-02 벤조산 1,4-디아자비시클로[2.2.2]옥트-2-일메틸 유도체, 그 제조 및 치료학적 응용
EEP199900218A EE9900218A (et) 1996-12-04 1997-12-02 1,4-diasabitsüklo[2.2.2]okt-2-üülmetüülbensoaadi derivaadid, nende valmistamine ja kasutamine raviks
PCT/FR1997/002174 WO1998024790A1 (fr) 1996-12-04 1997-12-02 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-ylmethyle, leur preparation et leur application en therapeutique
IL12992797A IL129927A0 (en) 1996-12-04 1997-12-02 1,4-Diazabicyclo (2.2.2) oct-2-ylmethyl derivatives their preparation and therapeutic application
TR1999/01068T TR199901068T2 (xx) 1996-12-04 1997-12-02 1, 4-Diazabisiklo $2.2.2]oct-2-ilmetil benzoat t�revleri, haz�rlanmalar� ve tedavideki uygulamalar�.
SK741-99A SK74199A3 (en) 1996-12-04 1997-12-02 1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their preparation and therapeutic application
NZ336044A NZ336044A (en) 1996-12-04 1997-12-02 1,4-diazabicyclo[2.2.2]oct-2-ylmethyl benzoate derivatives, their preparation and therapeutic application
AU76245/98A AU7624598A (en) 1996-12-04 1997-12-02 1,4-diazabicyclo (2.2.2) Oct-2-ylmethyl derivatives, their preparation and the rapeutic application
CN97180353A CN1239962A (zh) 1996-12-04 1997-12-02 1,4－二氮杂二环[2,2,2]辛－2－基甲基苯甲酸酯衍生物,其制备及其医疗用途
EP97948976A EP0942910A1 (fr) 1996-12-04 1997-12-02 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-ylmethyle, leur preparation et leur application en therapeutique
CA002271072A CA2271072A1 (fr) 1996-12-04 1997-12-02 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-ylmethyle, leur preparation et leur application en therapeutique
HU9904206A HUP9904206A3 (en) 1996-12-04 1997-12-02 1,4-diazabicyclo[2.2.2.]oct-2-ylmethyl derivatives,their preparation and therapeutic application
JP52527298A JP2001504855A (ja) 1996-12-04 1997-12-02 １，４−ジアザビシクロ［２．２．２］オクタ−２−イルメチルベンゾアート誘導体、その製造およびその治療上の適用
BR9714215-8A BR9714215A (pt) 1996-12-04 1997-12-02 Derivados de benzoato de 1,4-diazabiciclo[2.2.2]oct-2-ilmetila, seu preparo e sua aplicação em terapêutica
CZ991937A CZ193799A3 (cs) 1996-12-04 1997-12-02 Deriváty 1,4-diazabicyklo[2,2,2]okt-2-ylmethylbenzoátu, způsob jejich přípravy a jejich použití při léčení
BG103432A BG103432A (en) 1996-12-04 1999-05-26 Derivatives of 1,4-diazabicyclo[2.2.2]oct-2-ylmethylbenzoate, method for their preparation and application in therapy
NO992676A NO992676L (no) 1996-12-04 1999-06-02 1,4-diazabicyklo[2,2,2]okt-2-ylmetylderivater, deres fremstilling og terapeutiske anvendelse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614847A FR2756563B1 (fr) 1996-12-04 1996-12-04 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2756563A1 FR2756563A1 (fr) 1998-06-05
FR2756563B1 true FR2756563B1 (fr) 1998-12-24

Family

ID=9498306

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9614847A Expired - Fee Related FR2756563B1 (fr) 1996-12-04 1996-12-04 Derives de benzoate de 1,4-diazabicyclo[2.2.2]oct-2-yl- methyle, leur preparation et leur application en therapeutique

Country Status (19)

Country Link
US (1) US6057321A (fr)
EP (1) EP0942910A1 (fr)
JP (1) JP2001504855A (fr)
KR (1) KR20000069283A (fr)
CN (1) CN1239962A (fr)
AU (1) AU7624598A (fr)
BG (1) BG103432A (fr)
BR (1) BR9714215A (fr)
CA (1) CA2271072A1 (fr)
CZ (1) CZ193799A3 (fr)
EE (1) EE9900218A (fr)
FR (1) FR2756563B1 (fr)
HU (1) HUP9904206A3 (fr)
IL (1) IL129927A0 (fr)
NO (1) NO992676L (fr)
NZ (1) NZ336044A (fr)
SK (1) SK74199A3 (fr)
TR (1) TR199901068T2 (fr)
WO (1) WO1998024790A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ309980A (en) 1995-06-07 2001-06-29 Noven Pharma Transdermal composition containing a blend of one or more polymers, one or more drugs that has a low molecular weight and is liquid at room temperature
ATE550309T1 (de) * 2003-04-08 2012-04-15 Basf Se Lichtstabilisierende polymerdispergiermittel in pigmentdispersionen
US7880683B2 (en) * 2004-08-18 2011-02-01 Ruckus Wireless, Inc. Antennas with polarization diversity
WO2008133004A1 (fr) 2007-04-16 2008-11-06 Daikin Industries, Ltd. Composition élastomère à teneur en fluor et matériau d'étanchéité composé de celle-ci
US20100204438A1 (en) * 2007-09-03 2010-08-12 Basf Se Method for producing teda derivatives
US20110077376A1 (en) * 2008-05-30 2011-03-31 Katsumi Tokumoto Process for producing hydroxyalkyltriethylenediamine, and catalyst composition for the production of polyurethane resin using it
PL2295438T3 (pl) 2008-05-30 2015-06-30 Tosoh Corp Sposób wytwarzania kompozycji zawierającej hydroksyalkilotrietylenodiaminę i kompozycja katalizatora do wytwarzania żywicy poliuretanowej z zastosowaniem kompozycji hydroksyalkilotrietylenodiaminy
CN101671336B (zh) * 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
JP5504835B2 (ja) * 2009-11-13 2014-05-28 東ソー株式会社 ヒドロキシアルキルピペラジン類及び／又はヒドロキシメチルトリエチレンジアミン類の製造方法
JP5549847B2 (ja) * 2009-11-16 2014-07-16 東ソー株式会社 Ｎ−（２−アルコキシメチル）トリエチレンジアミン類の製造法
JP5707912B2 (ja) * 2010-12-08 2015-04-30 東ソー株式会社 Ｎ−（ジヒドロキシアルキル）ジエチレントリアミン類の組成物、及びそれを用いた２−ヒドロキシ（アルキル）トリエチレンジアミン類の製造方
JP6393959B2 (ja) 2012-05-31 2018-09-26 東ソー株式会社 ポリウレタン樹脂製造用触媒組成物及びそれを用いたポリウレタン樹脂の製造方法
JP6252152B2 (ja) * 2013-12-11 2017-12-27 東ソー株式会社 二環式アミン化合物の製造方法
KR20220055152A (ko) 2020-10-26 2022-05-03 인하대학교 산학협력단 급성 융모양막염 진단용 조성물 및 이를 이용한 급성 융모양막염 진단방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
TW282460B (fr) * 1993-12-28 1996-08-01 Yamanouchi Pharma Co Ltd
FR2735475B1 (fr) * 1995-06-13 1997-07-11 Synthelabo Derives de n-((1,4-diazabicyclo(2.2.2)oct-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NO992676L (no) 1999-07-29
CA2271072A1 (fr) 1998-06-11
CN1239962A (zh) 1999-12-29
EE9900218A (et) 1999-12-15
HUP9904206A3 (en) 2000-07-28
KR20000069283A (ko) 2000-11-25
NZ336044A (en) 2000-03-27
US6057321A (en) 2000-05-02
BR9714215A (pt) 2000-04-18
JP2001504855A (ja) 2001-04-10
AU7624598A (en) 1998-06-29
IL129927A0 (en) 2000-02-29
CZ193799A3 (cs) 1999-09-15
NO992676D0 (no) 1999-06-02
FR2756563A1 (fr) 1998-06-05
TR199901068T2 (xx) 1999-07-21
BG103432A (en) 2000-06-30
EP0942910A1 (fr) 1999-09-22
SK74199A3 (en) 2000-02-14
WO1998024790A1 (fr) 1998-06-11
HUP9904206A2 (hu) 2000-06-28

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