ATE232865T1 - 1,4-diazabicyclo(3.2.2)nonan-4-carboxylat und carboxamidderivate, ihre herstellung und therapeutische verwendung - Google Patents
1,4-diazabicyclo(3.2.2)nonan-4-carboxylat und carboxamidderivate, ihre herstellung und therapeutische verwendungInfo
- Publication number
- ATE232865T1 ATE232865T1 AT00911011T AT00911011T ATE232865T1 AT E232865 T1 ATE232865 T1 AT E232865T1 AT 00911011 T AT00911011 T AT 00911011T AT 00911011 T AT00911011 T AT 00911011T AT E232865 T1 ATE232865 T1 AT E232865T1
- Authority
- AT
- Austria
- Prior art keywords
- nonan
- diazabicyclo
- carboxylate
- preparation
- therapeutic use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9903934A FR2791678B1 (fr) | 1999-03-30 | 1999-03-30 | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
PCT/FR2000/000697 WO2000058311A1 (fr) | 1999-03-30 | 2000-03-21 | Derives de 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates et carboxamides, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE232865T1 true ATE232865T1 (de) | 2003-03-15 |
Family
ID=9543787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00911011T ATE232865T1 (de) | 1999-03-30 | 2000-03-21 | 1,4-diazabicyclo(3.2.2)nonan-4-carboxylat und carboxamidderivate, ihre herstellung und therapeutische verwendung |
Country Status (15)
Country | Link |
---|---|
US (1) | US6987106B1 (de) |
EP (1) | EP1165559B1 (de) |
JP (1) | JP4500454B2 (de) |
AR (1) | AR023188A1 (de) |
AT (1) | ATE232865T1 (de) |
AU (1) | AU3301800A (de) |
CO (1) | CO5180557A1 (de) |
DE (1) | DE60001451T2 (de) |
DK (1) | DK1165559T3 (de) |
ES (1) | ES2192520T3 (de) |
FR (1) | FR2791678B1 (de) |
PE (1) | PE20001600A1 (de) |
TW (1) | TWI221843B (de) |
UY (1) | UY26082A1 (de) |
WO (1) | WO2000058311A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1289996E (pt) | 2000-05-25 | 2005-07-29 | Targacept Inc | Heteroarildiazabicicloalcanos como ligandos do receptor colinergico nicotinico |
US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
ES2275808T3 (es) * | 2001-02-06 | 2007-06-16 | Pfizer Products Inc. | Composiciones farmaceuticas para el tratamiento de trastornos del snc y otros trastornos. |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
BR0314485A (pt) | 2002-09-25 | 2005-07-26 | Memory Pharm Corp | Indazóis, benzotiazóis e benzoisotiazóis, composto, composição farmacêutica, método desativação/estimulação seletiva de receptores nicotìnicos de a-7 em um mamìfero e método de tratamento e/ou prevenção de uma doença com os mesmos |
ATE445618T1 (de) * | 2003-02-27 | 2009-10-15 | Neurosearch As | Neue diazabicyclische arylderivate |
US20070244097A1 (en) * | 2003-12-22 | 2007-10-18 | Astrazeneca Ab | Nicotinic AcetylcholineReceptor Ligands |
TW200529860A (en) * | 2003-12-22 | 2005-09-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
CA2550689A1 (en) | 2003-12-22 | 2005-07-14 | Memory Pharmaceuticals Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
JP2007520527A (ja) * | 2004-02-04 | 2007-07-26 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとしてのジアザ2環式アリール誘導体 |
WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
JP2007534692A (ja) | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、1h−インダゾール、1,2−ベンズイソキサゾール、1,2−ベンゾイソチアゾール、ならびにその調製および使用 |
KR20070015607A (ko) * | 2004-05-07 | 2007-02-05 | 메모리 파마슈티칼스 코포레이션 | 1h-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도 |
US7652010B2 (en) * | 2004-10-15 | 2010-01-26 | Neurosearch A/S | Azabicyclic aryl derivatives and their medical use |
MX2007007328A (es) | 2004-12-22 | 2007-07-25 | Memory Pharm Corp | Ligandos del receptor alfa-7 nicotinico y preparacion y sus usos. |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
WO2007093600A1 (en) * | 2006-02-14 | 2007-08-23 | Neurosearch A/S | Novel diazabicycloalkane derivatives and their medical use |
JP2007217370A (ja) * | 2006-02-17 | 2007-08-30 | Nard Inst Ltd | ポジトロン断層撮影法および該方法に用いるポジトロン放出化合物 |
WO2007135120A1 (en) | 2006-05-23 | 2007-11-29 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives and their medical use |
EP2083921A2 (de) | 2006-09-04 | 2009-08-05 | Neurosearch A/S | Pharmazeutische kombinationen aus einem nikotinrezeptormodulator und einem mittel zur intensivierung kognitiver funktionen |
WO2008119710A1 (en) * | 2007-03-30 | 2008-10-09 | Neurosearch A/S | Two-phase test method for characterizing the effect of a chemical compound on a test animal and maze for carrying out the method |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
FR2931677B1 (fr) * | 2008-06-02 | 2010-08-20 | Sanofi Aventis | Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition la contenant et son utilisation dans le traitement des troubles cognitifs |
FR2931823B1 (fr) * | 2008-06-02 | 2012-08-17 | Sanofi Aventis | Sel de fumarate du 1,4-diazabicyclo°3.2.2!nonane-carboxylate de 4-bromophenyle, ses formes cristallines, leur preparation et leur utilisation en therapeutique |
PT2540297E (pt) | 2008-11-19 | 2015-08-26 | Forum Pharmaceuticals Inc | Tratamento de distúrbios cognitivos com (r)-7-cloro-n- (quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmaceuticamente aceitáveis desta |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
AU2010247835A1 (en) * | 2009-05-11 | 2011-12-08 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
SA111320455B1 (ar) | 2010-05-17 | 2014-10-16 | Envivo Pharmaceuticals Inc | صورة بلورية من (R)-7- كلورو -N- (كينوكليدين -3- يل) بنزو[b] ثيوفين -2- كربوكساميد هيدروكلوريد أحادي الهيدرات |
KR101987736B1 (ko) * | 2011-03-18 | 2019-06-11 | 젠자임 코포레이션 | 글루코실세라마이드 합성효소 억제제 |
EP3666272A1 (de) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit |
MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
MX2023001014A (es) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Composiciones farmaceuticas que comprenden venglustat. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0235878A3 (de) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Neue Verbindungen |
JP2668670B2 (ja) * | 1995-03-24 | 1997-10-27 | 日本たばこ産業株式会社 | ジアザビシクロ[3.3.1]ノナン誘導体、その中間体及びその医薬用途 |
DE69822300T2 (de) * | 1997-06-30 | 2005-03-10 | Targacept, Inc. | 3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungen |
-
1999
- 1999-03-30 FR FR9903934A patent/FR2791678B1/fr not_active Expired - Fee Related
-
2000
- 2000-03-21 AT AT00911011T patent/ATE232865T1/de active
- 2000-03-21 DK DK00911011T patent/DK1165559T3/da active
- 2000-03-21 ES ES00911011T patent/ES2192520T3/es not_active Expired - Lifetime
- 2000-03-21 DE DE60001451T patent/DE60001451T2/de not_active Expired - Lifetime
- 2000-03-21 US US09/937,045 patent/US6987106B1/en not_active Expired - Lifetime
- 2000-03-21 EP EP00911011A patent/EP1165559B1/de not_active Expired - Lifetime
- 2000-03-21 AU AU33018/00A patent/AU3301800A/en not_active Abandoned
- 2000-03-21 WO PCT/FR2000/000697 patent/WO2000058311A1/fr active IP Right Grant
- 2000-03-21 JP JP2000608013A patent/JP4500454B2/ja not_active Expired - Fee Related
- 2000-03-28 AR ARP000101379A patent/AR023188A1/es active IP Right Grant
- 2000-03-28 TW TW089105707A patent/TWI221843B/zh not_active IP Right Cessation
- 2000-03-28 UY UY26082A patent/UY26082A1/es not_active IP Right Cessation
- 2000-03-28 CO CO00022162A patent/CO5180557A1/es active IP Right Grant
- 2000-03-30 PE PE2000000274A patent/PE20001600A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6987106B1 (en) | 2006-01-17 |
CO5180557A1 (es) | 2002-07-30 |
JP2002540208A (ja) | 2002-11-26 |
EP1165559A1 (de) | 2002-01-02 |
FR2791678B1 (fr) | 2001-05-04 |
FR2791678A1 (fr) | 2000-10-06 |
DK1165559T3 (da) | 2003-06-10 |
TWI221843B (en) | 2004-10-11 |
AU3301800A (en) | 2000-10-16 |
UY26082A1 (es) | 2000-10-31 |
PE20001600A1 (es) | 2001-04-01 |
JP4500454B2 (ja) | 2010-07-14 |
DE60001451D1 (de) | 2003-03-27 |
DE60001451T2 (de) | 2004-01-15 |
EP1165559B1 (de) | 2003-02-19 |
AR023188A1 (es) | 2002-09-04 |
WO2000058311A1 (fr) | 2000-10-05 |
ES2192520T3 (es) | 2003-10-16 |
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