DE60100621D1 - 4-heteroaryl-1,4-diazabicyclo 3.2.2.]nonane, ihre herstellung und ihre therapeutische anwendung - Google Patents
4-heteroaryl-1,4-diazabicyclo 3.2.2.]nonane, ihre herstellung und ihre therapeutische anwendungInfo
- Publication number
- DE60100621D1 DE60100621D1 DE60100621T DE60100621T DE60100621D1 DE 60100621 D1 DE60100621 D1 DE 60100621D1 DE 60100621 T DE60100621 T DE 60100621T DE 60100621 T DE60100621 T DE 60100621T DE 60100621 D1 DE60100621 D1 DE 60100621D1
- Authority
- DE
- Germany
- Prior art keywords
- nonanese
- diazabicyclo
- heteroaryl
- manufacture
- therapeutic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0001098A FR2804430B1 (fr) | 2000-01-28 | 2000-01-28 | Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR0001098 | 2000-01-28 | ||
PCT/FR2001/000227 WO2001055150A1 (fr) | 2000-01-28 | 2001-01-24 | Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60100621D1 true DE60100621D1 (de) | 2003-09-25 |
DE60100621T2 DE60100621T2 (de) | 2004-06-17 |
Family
ID=8846415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60100621T Expired - Lifetime DE60100621T2 (de) | 2000-01-28 | 2001-01-24 | 4-heteroaryl-1,4-diazabicyclo 3.2.2.]nonane, ihre herstellung und ihre therapeutische anwendung |
Country Status (9)
Country | Link |
---|---|
US (1) | US6835730B2 (de) |
EP (1) | EP1254139B1 (de) |
JP (1) | JP4759199B2 (de) |
AR (1) | AR027296A1 (de) |
AT (1) | ATE247658T1 (de) |
AU (1) | AU2001235595A1 (de) |
DE (1) | DE60100621T2 (de) |
FR (1) | FR2804430B1 (de) |
WO (1) | WO2001055150A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
FR2840896B1 (fr) * | 2002-06-18 | 2005-04-08 | Sanofi Synthelabo | Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
JP2006504690A (ja) | 2002-09-10 | 2006-02-09 | ファイザー・プロダクツ・インク | Cns及びその他の障害の治療に有用なジアザ二環式化合物 |
KR20050062575A (ko) * | 2002-09-30 | 2005-06-23 | 뉴로서치 에이/에스 | 신규한 1,4-디아자바이사이클로알칸 유도체, 이의 제법 및용도 |
DE60326894D1 (de) * | 2002-09-30 | 2009-05-07 | Neurosearch As | 1,4-Diazabicycloalkanderivate, deren Herstellung und Verwendung |
US7456171B2 (en) | 2002-10-08 | 2008-11-25 | Sanofi-Aventis | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof |
FR2845388B1 (fr) * | 2002-10-08 | 2004-11-12 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.2]nonanecarboxamides, leur preparation et leur application en therapeutique |
US7678788B2 (en) * | 2003-02-27 | 2010-03-16 | Neurosearch A/S | Diazabicyclic aryl derivatives |
CA2555311A1 (en) * | 2004-02-04 | 2005-08-18 | Neurosearch A/S | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands |
US20100286128A1 (en) * | 2007-08-17 | 2010-11-11 | Dan Peters | 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine-receptor ligands |
MX2010005040A (es) * | 2007-11-14 | 2010-05-21 | Neurosearch As | Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico. |
HUE037938T2 (hu) | 2008-11-19 | 2018-09-28 | Forum Pharmaceuticals Inc | Skizofrénia negatív tüneteinek kezelése (R)-7-klór-N-(kinuklidin-3-il)benzo[b]tiofén-2-karboxamiddal és ennek gyógyszerészetileg elfogadható sójával |
RU2011150248A (ru) * | 2009-05-11 | 2013-06-20 | Энвиво Фармасьютикалз, Инк. | Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы |
JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
PT3029039T (pt) | 2010-05-17 | 2017-11-28 | Forum Pharmaceuticals Inc | Formulações farmacêuticas que compreendem formas cristalinas de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida mono-hidratado |
TW201311698A (zh) * | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之1,4-二氮雜雙環[3.2.2]壬烷 |
CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
CN105906563B (zh) * | 2014-11-10 | 2019-01-22 | 苏州康润医药有限公司 | 7,8-二氟喹啉-3-甲酸的合成方法 |
CN104447547B (zh) * | 2014-11-10 | 2017-04-19 | 苏州康润医药有限公司 | 4‑氨基异喹啉‑8‑甲酸甲酯的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
FR2786769B1 (fr) | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
-
2000
- 2000-01-28 FR FR0001098A patent/FR2804430B1/fr not_active Expired - Fee Related
-
2001
- 2001-01-24 JP JP2001561009A patent/JP4759199B2/ja not_active Expired - Fee Related
- 2001-01-24 EP EP01907686A patent/EP1254139B1/de not_active Expired - Lifetime
- 2001-01-24 DE DE60100621T patent/DE60100621T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/FR2001/000227 patent/WO2001055150A1/fr active IP Right Grant
- 2001-01-24 AT AT01907686T patent/ATE247658T1/de not_active IP Right Cessation
- 2001-01-24 AU AU2001235595A patent/AU2001235595A1/en not_active Abandoned
- 2001-01-24 US US10/181,870 patent/US6835730B2/en not_active Expired - Lifetime
- 2001-01-26 AR ARP010100341A patent/AR027296A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
FR2804430B1 (fr) | 2002-03-22 |
FR2804430A1 (fr) | 2001-08-03 |
US6835730B2 (en) | 2004-12-28 |
WO2001055150A1 (fr) | 2001-08-02 |
EP1254139A1 (de) | 2002-11-06 |
ATE247658T1 (de) | 2003-09-15 |
AU2001235595A1 (en) | 2001-08-07 |
JP2003523359A (ja) | 2003-08-05 |
EP1254139B1 (de) | 2003-08-20 |
AR027296A1 (es) | 2003-03-19 |
JP4759199B2 (ja) | 2011-08-31 |
US20030119840A1 (en) | 2003-06-26 |
DE60100621T2 (de) | 2004-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-AVENTIS, PARIS, FR |
|
8364 | No opposition during term of opposition | ||
R082 | Change of representative |
Ref document number: 1254139 Country of ref document: EP Representative=s name: TER MEER STEINMEISTER & PARTNER GBR PATENTANWA, DE |