PT994875E - Derivados de 3-piridil-1-aza-biciclo-alcano para a prevencao e tratamento de desordens do snc - Google Patents
Derivados de 3-piridil-1-aza-biciclo-alcano para a prevencao e tratamento de desordens do sncInfo
- Publication number
- PT994875E PT994875E PT98918598T PT98918598T PT994875E PT 994875 E PT994875 E PT 994875E PT 98918598 T PT98918598 T PT 98918598T PT 98918598 T PT98918598 T PT 98918598T PT 994875 E PT994875 E PT 994875E
- Authority
- PT
- Portugal
- Prior art keywords
- aza
- pyridyl
- bicyclo
- alcano
- bicycle
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- FDAOGGNPGDPKBY-UHFFFAOYSA-N 2-pyridin-3-yl-1-azabicyclo[2.2.1]heptane Chemical class C1CN2CC1CC2C1=CC=CN=C1 FDAOGGNPGDPKBY-UHFFFAOYSA-N 0.000 abstract 1
- WIEWCOLOPGXZDJ-UHFFFAOYSA-N 2-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN2CCC1CCC2C1=CC=CN=C1 WIEWCOLOPGXZDJ-UHFFFAOYSA-N 0.000 abstract 1
- SXRRAFMKMZGQJY-UHFFFAOYSA-N 3-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN(C2)CCC1CC2C1=CC=CN=C1 SXRRAFMKMZGQJY-UHFFFAOYSA-N 0.000 abstract 1
- PHXZTDLBLWHZEJ-UHFFFAOYSA-N 7-pyridin-3-yl-1-azabicyclo[2.2.1]heptane Chemical compound C1CN2CCC1C2C1=CC=CN=C1 PHXZTDLBLWHZEJ-UHFFFAOYSA-N 0.000 abstract 1
- BXZMIGKZXVFLGL-UHFFFAOYSA-N 7-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN2CCCC1CC2C1=CC=CN=C1 BXZMIGKZXVFLGL-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000003957 neurotransmitter release Effects 0.000 abstract 1
- YJYPZLAZNIGNRP-UHFFFAOYSA-N rjr-2429 Chemical compound C1CN2CCC1CC2C1=CC=CN=C1 YJYPZLAZNIGNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/885,768 US6624173B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions for treating and/or preventing CNS disorders |
| US08/885,397 US6525065B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions and methods for effecting dopamine release |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT994875E true PT994875E (pt) | 2004-06-30 |
Family
ID=27128761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98918598T PT994875E (pt) | 1997-06-30 | 1998-04-22 | Derivados de 3-piridil-1-aza-biciclo-alcano para a prevencao e tratamento de desordens do snc |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0994875B1 (pt) |
| JP (1) | JP2002511090A (pt) |
| AT (1) | ATE261443T1 (pt) |
| AU (1) | AU7149798A (pt) |
| CA (1) | CA2294990C (pt) |
| DE (1) | DE69822300T2 (pt) |
| DK (1) | DK0994875T3 (pt) |
| ES (1) | ES2214707T3 (pt) |
| PT (1) | PT994875E (pt) |
| WO (1) | WO1999000385A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| EP1225955A1 (en) * | 1999-11-01 | 2002-07-31 | Targacept, Inc. | Aryl olefinic azacyclic, and aryl acetylenic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| CA2420235A1 (en) * | 2000-08-21 | 2002-02-28 | Georgetown University | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| PT1330452E (pt) | 2000-09-20 | 2009-01-22 | Ortho Mcneil Pharm Inc | Derivados de pirazina como moduladores de tirosina-cinases |
| GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
| JP4923630B2 (ja) * | 2006-03-02 | 2012-04-25 | 宇部興産株式会社 | ４−置換テトラヒドロピランの製造方法 |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| JP5413441B2 (ja) * | 2011-12-09 | 2014-02-12 | 宇部興産株式会社 | ４−置換テトラヒドロピランの製造方法 |
| CN104311514B (zh) * | 2014-10-14 | 2016-06-22 | 安徽扬子化工有限公司 | 3-羟甲基四氢呋喃酯的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2022886A1 (en) * | 1989-08-08 | 1991-02-09 | Raymond Baker | Substituted pyridines, their preparation, formulations and use in dementia |
| US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| AU7474794A (en) * | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| WO1996036637A1 (en) * | 1995-05-17 | 1996-11-21 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
-
1998
- 1998-04-22 JP JP50551699A patent/JP2002511090A/ja not_active Ceased
- 1998-04-22 EP EP98918598A patent/EP0994875B1/en not_active Expired - Lifetime
- 1998-04-22 CA CA002294990A patent/CA2294990C/en not_active Expired - Fee Related
- 1998-04-22 DK DK98918598T patent/DK0994875T3/da active
- 1998-04-22 PT PT98918598T patent/PT994875E/pt unknown
- 1998-04-22 WO PCT/US1998/008145 patent/WO1999000385A1/en not_active Ceased
- 1998-04-22 AU AU71497/98A patent/AU7149798A/en not_active Abandoned
- 1998-04-22 DE DE69822300T patent/DE69822300T2/de not_active Expired - Fee Related
- 1998-04-22 AT AT98918598T patent/ATE261443T1/de not_active IP Right Cessation
- 1998-04-22 ES ES98918598T patent/ES2214707T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69822300D1 (de) | 2004-04-15 |
| ES2214707T3 (es) | 2004-09-16 |
| EP0994875A1 (en) | 2000-04-26 |
| ATE261443T1 (de) | 2004-03-15 |
| CA2294990A1 (en) | 1999-01-07 |
| CA2294990C (en) | 2007-03-06 |
| JP2002511090A (ja) | 2002-04-09 |
| AU7149798A (en) | 1999-01-19 |
| DE69822300T2 (de) | 2005-03-10 |
| EP0994875B1 (en) | 2004-03-10 |
| WO1999000385A1 (en) | 1999-01-07 |
| DK0994875T3 (da) | 2004-06-21 |
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