DE69822300D1 - 3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungen - Google Patents
3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungenInfo
- Publication number
- DE69822300D1 DE69822300D1 DE69822300T DE69822300T DE69822300D1 DE 69822300 D1 DE69822300 D1 DE 69822300D1 DE 69822300 T DE69822300 T DE 69822300T DE 69822300 T DE69822300 T DE 69822300T DE 69822300 D1 DE69822300 D1 DE 69822300D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridyl
- aza
- bicyclo
- azabicycloalkan
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US885768 | 1997-06-30 | ||
US885397 | 1997-06-30 | ||
US08/885,397 US6525065B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions and methods for effecting dopamine release |
US08/885,768 US6624173B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions for treating and/or preventing CNS disorders |
PCT/US1998/008145 WO1999000385A1 (en) | 1997-06-30 | 1998-04-22 | 3-pyridyl-1-aza-bicyclo-alkane derivatives for prevention and treatment of cns disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69822300D1 true DE69822300D1 (de) | 2004-04-15 |
DE69822300T2 DE69822300T2 (de) | 2005-03-10 |
Family
ID=27128761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69822300T Expired - Fee Related DE69822300T2 (de) | 1997-06-30 | 1998-04-22 | 3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungen |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0994875B1 (de) |
JP (1) | JP2002511090A (de) |
AT (1) | ATE261443T1 (de) |
AU (1) | AU7149798A (de) |
CA (1) | CA2294990C (de) |
DE (1) | DE69822300T2 (de) |
DK (1) | DK0994875T3 (de) |
ES (1) | ES2214707T3 (de) |
PT (1) | PT994875E (de) |
WO (1) | WO1999000385A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
EP1225955A1 (de) * | 1999-11-01 | 2002-07-31 | Targacept, Inc. | Aryl-olefinische-azacyclische, und aryl-acetylen-azacyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als inhibitoren von nikotin cholinergen rezeptoren |
CA2420235A1 (en) * | 2000-08-21 | 2002-02-28 | Georgetown University | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
US6710048B2 (en) | 2000-09-20 | 2004-03-23 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
JP4923630B2 (ja) * | 2006-03-02 | 2012-04-25 | 宇部興産株式会社 | 4−置換テトラヒドロピランの製造方法 |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
JP5413441B2 (ja) * | 2011-12-09 | 2014-02-12 | 宇部興産株式会社 | 4−置換テトラヒドロピランの製造方法 |
CN104311514B (zh) * | 2014-10-14 | 2016-06-22 | 安徽扬子化工有限公司 | 3-羟甲基四氢呋喃酯的合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0412798A3 (en) * | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
AU7474794A (en) * | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
WO1996036637A1 (en) * | 1995-05-17 | 1996-11-21 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
-
1998
- 1998-04-22 WO PCT/US1998/008145 patent/WO1999000385A1/en active IP Right Grant
- 1998-04-22 PT PT98918598T patent/PT994875E/pt unknown
- 1998-04-22 CA CA002294990A patent/CA2294990C/en not_active Expired - Fee Related
- 1998-04-22 JP JP50551699A patent/JP2002511090A/ja not_active Ceased
- 1998-04-22 ES ES98918598T patent/ES2214707T3/es not_active Expired - Lifetime
- 1998-04-22 DK DK98918598T patent/DK0994875T3/da active
- 1998-04-22 DE DE69822300T patent/DE69822300T2/de not_active Expired - Fee Related
- 1998-04-22 AU AU71497/98A patent/AU7149798A/en not_active Abandoned
- 1998-04-22 AT AT98918598T patent/ATE261443T1/de not_active IP Right Cessation
- 1998-04-22 EP EP98918598A patent/EP0994875B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0994875A1 (de) | 2000-04-26 |
EP0994875B1 (de) | 2004-03-10 |
ES2214707T3 (es) | 2004-09-16 |
PT994875E (pt) | 2004-06-30 |
JP2002511090A (ja) | 2002-04-09 |
DE69822300T2 (de) | 2005-03-10 |
ATE261443T1 (de) | 2004-03-15 |
CA2294990A1 (en) | 1999-01-07 |
CA2294990C (en) | 2007-03-06 |
AU7149798A (en) | 1999-01-19 |
WO1999000385A1 (en) | 1999-01-07 |
DK0994875T3 (da) | 2004-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Maelicke et al. | Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease | |
SI1678172T1 (sl) | AzabicikliŽŤne spojine za lajšanje boleŽŤine in zdravljenje motenj centralnega ĹľivŽŤnega sistema | |
WO2004108668A3 (en) | Alpha-7 neuronal nicotinic receptor ligands: compositions and methods of use | |
DE60045427D1 (de) | Bupropinmetaboliten zur Behandlung von Dementia und anderen zerebrovasckulären Erkrankungen | |
DE60134453D1 (de) | Pharmazeutische Zusammensetzungen zur Behandlung von ZNS und anderen Krankheiten | |
DE69822300D1 (de) | 3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungen | |
MY144483A (en) | 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases | |
PH31335A (en) | Naphthalamides as central nervous system agent. | |
NO20041166L (no) | Anvendelse av optisk rent (+) norcisaprid sammen med et annet terapeutisk middel for fremstilling av et medikament | |
WO2006040451A3 (fr) | Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes | |
TW200531680A (en) | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease | |
DE68912419D1 (de) | Verwendung von Uridin zur Behandlung nervöser Störungen. | |
AP2002002465A0 (en) | Use of GABAA inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or Vitamin E for the treatment of cognitive disorders. | |
IL192287A0 (en) | Pharmaceutical compositions and methods for use | |
TW200735868A (en) | Compositions and methods for treating CNS disorders | |
TNSN99177A1 (fr) | COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE PYRIDO [1, 2-a] PYRAZINE ET PROCEDE POUR LEUR PREPARATION | |
AU4038000A (en) | 4-substituted quinoline derivatives as gaba receptor ligands | |
NZ515613A (en) | Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands | |
HK1098670A1 (en) | Use of 3-aza-1-oxa-dibenzo Äe,hÜ azulenes for the manufacture of pharmaceutical formulations for thetreatment and prevention of central nervous syste m disease and disorders |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: TARGACEPT, INC., WINSTON-SALEM, N.C., US |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |