WO2006040451A3 - Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes - Google Patents

Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes Download PDF

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Publication number
WO2006040451A3
WO2006040451A3 PCT/FR2005/002474 FR2005002474W WO2006040451A3 WO 2006040451 A3 WO2006040451 A3 WO 2006040451A3 FR 2005002474 W FR2005002474 W FR 2005002474W WO 2006040451 A3 WO2006040451 A3 WO 2006040451A3
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Prior art keywords
pyrido
novel
compounds
pharmaceutical compositions
compositions containing
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PCT/FR2005/002474
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English (en)
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WO2006040451A2 (fr
Inventor
Benoit Joseph
Laurent Meijer
Francois Liger
Original Assignee
Univ Claude Bernard Lyon
R S Ct Nat De La Rech Scient C
Benoit Joseph
Laurent Meijer
Francois Liger
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Application filed by Univ Claude Bernard Lyon, R S Ct Nat De La Rech Scient C, Benoit Joseph, Laurent Meijer, Francois Liger filed Critical Univ Claude Bernard Lyon
Publication of WO2006040451A2 publication Critical patent/WO2006040451A2/fr
Publication of WO2006040451A3 publication Critical patent/WO2006040451A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des nouveaux dérivés de 9H-pyrido[2,3-b]indole de formule (I), les compositions pharmaceutiques contenant de tels composés et leur utilisation pour la fabrication d'un médicament destiné au traitement ou à la prévention de cancers, de la maladie d'Alzheimer, de la maladie de Parkinson, d'accidents vasculaires cérébraux, de sclérose amyotrophique latérale (ALS), d'infections virales, de maladies auto-immunes, et de désordres neurodégénératifs.
PCT/FR2005/002474 2004-10-11 2005-10-07 Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes WO2006040451A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0410683 2004-10-11
FR0410683A FR2876377B1 (fr) 2004-10-11 2004-10-11 Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes

Publications (2)

Publication Number Publication Date
WO2006040451A2 WO2006040451A2 (fr) 2006-04-20
WO2006040451A3 true WO2006040451A3 (fr) 2006-06-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/002474 WO2006040451A2 (fr) 2004-10-11 2005-10-07 Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes

Country Status (2)

Country Link
FR (1) FR2876377B1 (fr)
WO (1) WO2006040451A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6997769B2 (ja) 2016-09-09 2022-02-10 エフ．ホフマン－ラ ロシュ アーゲー ２－（６－ニトロピリジン－３－イル）－９Ｈ－ジピリド［２，３－ｂ；３’，４’－ｄ］ピロールの製造方法

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Publication number Priority date Publication date Assignee Title
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7732447B2 (en) 2006-06-22 2010-06-08 Cephalon, Inc. Fused [d]pyridazin-7-ones
CA2666130A1 (fr) * 2006-10-09 2008-04-17 Takeda San Diego, Inc. Inhibiteurs de kinases
AU2007313961A1 (en) * 2006-10-09 2008-05-08 Takeda Pharmaceutical Company Limited Kinase inhibitors
EA200970361A1 (ru) * 2006-10-09 2010-02-26 Такеда Фармасьютикал Компани Лимитед Ингибиторы киназы
CN101573335A (zh) * 2006-10-09 2009-11-04 武田药品工业株式会社 激酶抑制剂
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
EP2194980A4 (fr) 2007-09-20 2012-01-18 D2E Llc Dérivés à base de fluor de pyrido[4,3-b]indoles hydrogénés dotés de propriétés neuroprotectrices et favorisant la cognition, procédé de préparation et utilisation
EP2161271A1 (fr) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Inhibiteurs d'alpha-carboline de NMP-ALK, RET, et Bcr-Abl
EP2662372A1 (fr) 2012-05-11 2013-11-13 Università Degli Studi Di Milano - Bicocca Alpha-carbolines pour le traitement du cancer
US10662193B2 (en) * 2014-01-21 2020-05-26 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
CA2960101C (fr) * 2014-09-05 2024-05-21 Allosteros Therapeutics, Inc. Derive de carboline substituee et compositions connexes utiles comme inhibiteurs de camkii
AU2019216264B2 (en) 2018-01-31 2023-08-31 Heparegenix Gmbh Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CN108218862B (zh) * 2018-02-07 2020-06-23 贵州医科大学 α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
WO2019243315A1 (fr) * 2018-06-21 2019-12-26 Heparegenix Gmbh Inhibiteurs de protéine kinase tricycliques pour favoriser la régénération du foie ou réduire ou prévenir la mort des hépatocytes
CN112424201B (zh) 2018-07-16 2024-04-02 海帕瑞吉尼克斯股份有限公司 促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂
CN114845719A (zh) * 2019-12-18 2022-08-02 蒙特利尔大学 作为抗癌化合物的cullin 3连接蛋白kbtbd4的调节剂

Citations (3)

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WO1997005137A1 (fr) * 1995-07-31 1997-02-13 Novo Nordisk A/S Composes heterocycliques, et preparation et utilisation de ces derniers
WO2004016614A2 (fr) * 2002-08-09 2004-02-26 Centre National De La Recherche Scientifique (C.N.R.S.) Derives de pyrrolo-pyrazines possedant une activite inhibitrice de kinase et applications biologiques
WO2004041817A1 (fr) * 2002-10-23 2004-05-21 Sanofi-Aventis Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005137A1 (fr) * 1995-07-31 1997-02-13 Novo Nordisk A/S Composes heterocycliques, et preparation et utilisation de ces derniers
WO2004016614A2 (fr) * 2002-08-09 2004-02-26 Centre National De La Recherche Scientifique (C.N.R.S.) Derives de pyrrolo-pyrazines possedant une activite inhibitrice de kinase et applications biologiques
WO2004041817A1 (fr) * 2002-10-23 2004-05-21 Sanofi-Aventis Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique.

Non-Patent Citations (2)

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Title
SONG YONGCHENG ET AL: "beta-Carbolines as specific inhibitors of cyclin-dependent kinases", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 7, 8 April 2002 (2002-04-08), pages 1129 - 1132, XP002330760, ISSN: 0960-894X *
WIECZOREK J. ET AL.: "Antineoplastic activity of azacarbazoles I. Synthesis and antitumor properties of alpha-carboline and its selected derivatives", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 34, no. 3, 1986, pages 315 - 321, XP009048570 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6997769B2 (ja) 2016-09-09 2022-02-10 エフ．ホフマン－ラ ロシュ アーゲー ２－（６－ニトロピリジン－３－イル）－９Ｈ－ジピリド［２，３－ｂ；３’，４’－ｄ］ピロールの製造方法

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Publication number Publication date
WO2006040451A2 (fr) 2006-04-20
FR2876377A1 (fr) 2006-04-14
FR2876377B1 (fr) 2007-03-16

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