TWI221843B - Derivatives 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamides, their preparation and their therapeutic application - Google Patents
Derivatives 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamides, their preparation and their therapeutic application Download PDFInfo
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- TWI221843B TWI221843B TW089105707A TW89105707A TWI221843B TW I221843 B TWI221843 B TW I221843B TW 089105707 A TW089105707 A TW 089105707A TW 89105707 A TW89105707 A TW 89105707A TW I221843 B TWI221843 B TW I221843B
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- compound
- nonane
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- atom
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- 230000001225 therapeutic effect Effects 0.000 title description 2
- RUFBGPCDOFYGTF-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid Chemical class OC(=O)N1CCN2CCC1CC2 RUFBGPCDOFYGTF-UHFFFAOYSA-N 0.000 title 1
- 150000003857 carboxamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 32
- -1 cyano, hydroxyl Chemical group 0.000 claims abstract description 15
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 7
- 125000005843 halogen group Chemical group 0.000 claims abstract description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 6
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 5
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9903934A FR2791678B1 (fr) | 1999-03-30 | 1999-03-30 | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI221843B true TWI221843B (en) | 2004-10-11 |
Family
ID=9543787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089105707A TWI221843B (en) | 1999-03-30 | 2000-03-28 | Derivatives 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamides, their preparation and their therapeutic application |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6987106B1 (enExample) |
| EP (1) | EP1165559B1 (enExample) |
| JP (1) | JP4500454B2 (enExample) |
| AR (1) | AR023188A1 (enExample) |
| AT (1) | ATE232865T1 (enExample) |
| AU (1) | AU3301800A (enExample) |
| CO (1) | CO5180557A1 (enExample) |
| DE (1) | DE60001451T2 (enExample) |
| DK (1) | DK1165559T3 (enExample) |
| ES (1) | ES2192520T3 (enExample) |
| FR (1) | FR2791678B1 (enExample) |
| PE (1) | PE20001600A1 (enExample) |
| TW (1) | TWI221843B (enExample) |
| UY (1) | UY26082A1 (enExample) |
| WO (1) | WO2000058311A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1289996B1 (en) | 2000-05-25 | 2005-04-06 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| JP2006519208A (ja) * | 2003-02-27 | 2006-08-24 | ニューロサーチ、アクティーゼルスカブ | 新規ジアザビシクロアリール誘導体 |
| PL1697378T3 (pl) | 2003-12-22 | 2008-04-30 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania |
| TW200529860A (en) * | 2003-12-22 | 2005-09-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| WO2005061511A1 (en) * | 2003-12-22 | 2005-07-07 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| AU2005210039B2 (en) | 2004-02-04 | 2010-09-02 | Neurosearch A/S | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands |
| WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| DE602005024677D1 (de) | 2004-04-22 | 2010-12-23 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen |
| RU2386633C2 (ru) * | 2004-05-07 | 2010-04-20 | Мемори Фармасьютиклз Корпорейшн | 1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения |
| CA2584836A1 (en) | 2004-10-15 | 2006-04-20 | Neurosearch A/S | Novel azabicyclic aryl derivatives and their medical use |
| JP2008525464A (ja) | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−７ニコチン性受容体リガンド並びにその製造及び使用 |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| US20090075983A1 (en) * | 2006-02-14 | 2009-03-19 | Dan Peters | Novel Diazabicycloalkane Derivatives and Their Medical Use |
| JP2007217370A (ja) * | 2006-02-17 | 2007-08-30 | Nard Inst Ltd | ポジトロン断層撮影法および該方法に用いるポジトロン放出化合物 |
| JP2009537598A (ja) * | 2006-05-23 | 2009-10-29 | ノイロサーチ アクティーゼルスカブ | 新規１，４−ジアザ−ビシクロ［３．２．２］ノナン誘導体及びそれらの医学的使用 |
| WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| WO2008119710A1 (en) * | 2007-03-30 | 2008-10-09 | Neurosearch A/S | Two-phase test method for characterizing the effect of a chemical compound on a test animal and maze for carrying out the method |
| SA08290475B1 (ar) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| FR2931677B1 (fr) * | 2008-06-02 | 2010-08-20 | Sanofi Aventis | Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition la contenant et son utilisation dans le traitement des troubles cognitifs |
| FR2931823B1 (fr) | 2008-06-02 | 2012-08-17 | Sanofi Aventis | Sel de fumarate du 1,4-diazabicyclo°3.2.2!nonane-carboxylate de 4-bromophenyle, ses formes cristallines, leur preparation et leur utilisation en therapeutique |
| HUE026815T2 (en) | 2008-11-19 | 2016-07-28 | Forum Pharmaceuticals Inc | Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| AU2010247835A1 (en) * | 2009-05-11 | 2011-12-08 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
| TWI519532B (zh) | 2010-05-17 | 2016-02-01 | 艾維沃製藥公司 | （Ｒ）－７－氯－Ｎ－（啶－３－基）苯並［b］噻吩－２－羧醯胺鹽酸鹽單水合物之結晶形體 |
| LT2685986T (lt) * | 2011-03-18 | 2020-03-10 | Genzyme Corporation | Gliukozilceramido sintazės slopiklis |
| RU2017136693A (ru) | 2012-05-08 | 2019-02-08 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| CN107188900B (zh) * | 2017-05-27 | 2019-09-06 | 北京师范大学 | α7烟碱型乙酰胆碱受体的配体化合物及其应用 |
| PT3920912T (pt) | 2019-02-04 | 2025-09-09 | Genzyme Corp | Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs) |
| IL295255A (en) | 2020-02-03 | 2022-10-01 | Genzyme Corp | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| IL300090A (en) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Pharmaceutical preparations containing VENGLUSTAT |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235878A3 (en) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Novel compounds |
| JP2668670B2 (ja) * | 1995-03-24 | 1997-10-27 | 日本たばこ産業株式会社 | ジアザビシクロ［３．３．１］ノナン誘導体、その中間体及びその医薬用途 |
| AU7149798A (en) * | 1997-06-30 | 1999-01-19 | R.J. Reynolds Tobacco Company | 3-pyridyl-1-aza-bicyclo-alkane derivatives for prevention and treatment of cn s disorders |
-
1999
- 1999-03-30 FR FR9903934A patent/FR2791678B1/fr not_active Expired - Fee Related
-
2000
- 2000-03-21 ES ES00911011T patent/ES2192520T3/es not_active Expired - Lifetime
- 2000-03-21 US US09/937,045 patent/US6987106B1/en not_active Expired - Lifetime
- 2000-03-21 AT AT00911011T patent/ATE232865T1/de active
- 2000-03-21 EP EP00911011A patent/EP1165559B1/fr not_active Expired - Lifetime
- 2000-03-21 DK DK00911011T patent/DK1165559T3/da active
- 2000-03-21 DE DE60001451T patent/DE60001451T2/de not_active Expired - Lifetime
- 2000-03-21 WO PCT/FR2000/000697 patent/WO2000058311A1/fr not_active Ceased
- 2000-03-21 AU AU33018/00A patent/AU3301800A/en not_active Abandoned
- 2000-03-21 JP JP2000608013A patent/JP4500454B2/ja not_active Expired - Fee Related
- 2000-03-28 UY UY26082A patent/UY26082A1/es not_active IP Right Cessation
- 2000-03-28 CO CO00022162A patent/CO5180557A1/es active IP Right Grant
- 2000-03-28 TW TW089105707A patent/TWI221843B/zh not_active IP Right Cessation
- 2000-03-28 AR ARP000101379A patent/AR023188A1/es active IP Right Grant
- 2000-03-30 PE PE2000000274A patent/PE20001600A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2791678A1 (fr) | 2000-10-06 |
| EP1165559B1 (fr) | 2003-02-19 |
| US6987106B1 (en) | 2006-01-17 |
| CO5180557A1 (es) | 2002-07-30 |
| DE60001451T2 (de) | 2004-01-15 |
| PE20001600A1 (es) | 2001-04-01 |
| JP2002540208A (ja) | 2002-11-26 |
| JP4500454B2 (ja) | 2010-07-14 |
| AU3301800A (en) | 2000-10-16 |
| DK1165559T3 (da) | 2003-06-10 |
| DE60001451D1 (de) | 2003-03-27 |
| FR2791678B1 (fr) | 2001-05-04 |
| UY26082A1 (es) | 2000-10-31 |
| AR023188A1 (es) | 2002-09-04 |
| WO2000058311A1 (fr) | 2000-10-05 |
| ES2192520T3 (es) | 2003-10-16 |
| EP1165559A1 (fr) | 2002-01-02 |
| ATE232865T1 (de) | 2003-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |