FR2781482B1 - Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2781482B1
FR2781482B1 FR9809552A FR9809552A FR2781482B1 FR 2781482 B1 FR2781482 B1 FR 2781482B1 FR 9809552 A FR9809552 A FR 9809552A FR 9809552 A FR9809552 A FR 9809552A FR 2781482 B1 FR2781482 B1 FR 2781482B1
Authority
FR
France
Prior art keywords
pyrrolizine
thieno
derivatives
novel
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9809552A
Other languages
English (en)
French (fr)
Other versions
FR2781482A1 (fr
Inventor
Sylvain Rault
Cecile Enguehard
Jean Charles Lancelot
Max Robba
Ghanem Atassi
Alain Pierre
Daniel Henri Caignard
Pierre Renard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR9809552A priority Critical patent/FR2781482B1/fr
Priority to NO19993608A priority patent/NO313521B1/no
Priority to BR9902841-7A priority patent/BR9902841A/pt
Priority to DE69905524T priority patent/DE69905524T2/de
Priority to JP11210412A priority patent/JP2000044572A/ja
Priority to CA002279099A priority patent/CA2279099C/fr
Priority to ES99401892T priority patent/ES2192827T3/es
Priority to US09/361,064 priority patent/US6071945A/en
Priority to DK99401892T priority patent/DK0982308T3/da
Priority to NZ336913A priority patent/NZ336913A/en
Priority to AT99401892T priority patent/ATE233266T1/de
Priority to EP99401892A priority patent/EP0982308B1/fr
Priority to CN99110693A priority patent/CN1122669C/zh
Priority to AU41171/99A priority patent/AU752505B2/en
Priority to ZA9904817A priority patent/ZA994817B/xx
Priority to HU9902546A priority patent/HU226377B1/hu
Priority to PL334624A priority patent/PL196580B1/pl
Publication of FR2781482A1 publication Critical patent/FR2781482A1/fr
Priority to HK00103590A priority patent/HK1024244A1/xx
Application granted granted Critical
Publication of FR2781482B1 publication Critical patent/FR2781482B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9809552A 1998-07-27 1998-07-27 Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2781482B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR9809552A FR2781482B1 (fr) 1998-07-27 1998-07-27 Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NO19993608A NO313521B1 (no) 1998-07-27 1999-07-23 Nye 8H-tieno-[2,3-b]pyrrolizin-8-on forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiskesammensetninger inneholdende dem
EP99401892A EP0982308B1 (fr) 1998-07-27 1999-07-26 Dérivés de 8H-(2,3-b)-pyrrolizine-8-one, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
JP11210412A JP2000044572A (ja) 1998-07-27 1999-07-26 新規８Ｈ―チエノ―〔２，３―ｂ〕ピロリジン―８―オン化合物、その製造の方法及びそれらを含む医薬組成物
CA002279099A CA2279099C (fr) 1998-07-27 1999-07-26 Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES99401892T ES2192827T3 (es) 1998-07-27 1999-07-26 Derivados de 8h-(2,3-b)-pirrolicin-8-ona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US09/361,064 US6071945A (en) 1998-07-27 1999-07-26 8H-thieno-[2,3-b]pyrrolizin-8-one compounds
DK99401892T DK0982308T3 (da) 1998-07-27 1999-07-26 Derivater af 8H-[2,3-b]pyrrolizin-8-on, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse
NZ336913A NZ336913A (en) 1998-07-27 1999-07-26 8h-thieno-[2,3-B]Pyrrolizin-8-one compounds and medicaments thereof
AT99401892T ATE233266T1 (de) 1998-07-27 1999-07-26 8h-(2,3-b)-pyrrolozin-8-one derivate, verfahren zur ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
BR9902841-7A BR9902841A (pt) 1998-07-27 1999-07-26 Compostos de 8h-tieno-{2,3-b}pirrolizin-8-ona, processo para suas preparações e composições farmacêuticas contendo os mesmos
DE69905524T DE69905524T2 (de) 1998-07-27 1999-07-26 8H-(2,3-b)-Pyrrolozin-8-one Derivate, Verfahren zur ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
CN99110693A CN1122669C (zh) 1998-07-27 1999-07-27 8H－噻吩并[2，3－b]吡咯嗪－8－酮化合物，其制备方法以及含有它们的药物组合物
AU41171/99A AU752505B2 (en) 1998-07-27 1999-07-27 New 8H-thieno-(2,3-b)pyrrolizin-8-one compounds, a process for their preparation and pharmaceutical compositions containing them
ZA9904817A ZA994817B (en) 1998-07-27 1999-07-27 8H-thieno-[2,3-b]pyrrolizin-8-one compounds, a process for their preparation and pharmaceutical compositions containing them.
HU9902546A HU226377B1 (en) 1998-07-27 1999-07-27 8h-thieno[2,3-b]pyrrolizin-8-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
PL334624A PL196580B1 (pl) 1998-07-27 1999-07-27 Nowe związki 8H-tieno-[2,3-b]pirolizyn-8-onu, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne oraz ich zastosowanie
HK00103590A HK1024244A1 (en) 1998-07-27 2000-06-15 8h-thieno-(2,3-b)pyrrolizin-8-one compounds, a process for their preir preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9809552A FR2781482B1 (fr) 1998-07-27 1998-07-27 Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2781482A1 FR2781482A1 (fr) 2000-01-28
FR2781482B1 true FR2781482B1 (fr) 2001-08-31

Family

ID=9529031

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9809552A Expired - Fee Related FR2781482B1 (fr) 1998-07-27 1998-07-27 Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US6071945A (no)
EP (1) EP0982308B1 (no)
JP (1) JP2000044572A (no)
CN (1) CN1122669C (no)
AT (1) ATE233266T1 (no)
AU (1) AU752505B2 (no)
BR (1) BR9902841A (no)
CA (1) CA2279099C (no)
DE (1) DE69905524T2 (no)
DK (1) DK0982308T3 (no)
ES (1) ES2192827T3 (no)
FR (1) FR2781482B1 (no)
HK (1) HK1024244A1 (no)
HU (1) HU226377B1 (no)
NO (1) NO313521B1 (no)
NZ (1) NZ336913A (no)
PL (1) PL196580B1 (no)
ZA (1) ZA994817B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100457758C (zh) * 2007-01-15 2009-02-04 沈阳中海生物技术开发有限公司 新的噻吩并吡咯里嗪类衍生物、其制备方法和含有它们的药物组合物
CN115746001A (zh) * 2022-09-19 2023-03-07 浙江工业大学 一种手性吡咯嗪-3-酮类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68921239T2 (de) * 1988-05-05 1995-09-14 Sandoz Ag 5-Aryl-substituierte-2,3-dihydro-imidazo[1,2-a]furo[3,2-c]- oder Thieno[2,3-c]pyridine.
US5705498A (en) * 1992-11-05 1998-01-06 Smithkline Beecham Plc. Piperidine derivatives as 5-HT4 receptor antagonists
JP3633008B2 (ja) * 1993-11-15 2005-03-30 三菱ウェルファーマ株式会社 チエノトリアゾロジアゼピン化合物
EP0702014A4 (en) * 1994-04-01 1996-08-07 Kyowa Hakko Kogyo Kk DC-89 DERIVATIVES
AU686888B2 (en) * 1994-09-14 1998-02-12 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use
FR2728571B1 (fr) * 1994-12-22 1997-01-31 Adir Nouveaux ethers d'oximes tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
PL196580B1 (pl) 2008-01-31
FR2781482A1 (fr) 2000-01-28
AU4117199A (en) 2000-02-17
AU752505B2 (en) 2002-09-19
EP0982308A1 (fr) 2000-03-01
ES2192827T3 (es) 2003-10-16
NZ336913A (en) 2000-06-23
BR9902841A (pt) 2000-05-09
NO313521B1 (no) 2002-10-14
JP2000044572A (ja) 2000-02-15
CA2279099C (fr) 2003-06-17
PL334624A1 (en) 2000-01-31
DK0982308T3 (da) 2003-05-12
ZA994817B (en) 2000-02-02
DE69905524T2 (de) 2003-12-11
ATE233266T1 (de) 2003-03-15
HUP9902546A2 (hu) 2000-04-28
HU226377B1 (en) 2008-10-28
DE69905524D1 (de) 2003-04-03
HK1024244A1 (en) 2000-10-05
NO993608L (no) 2000-01-28
US6071945A (en) 2000-06-06
CN1244529A (zh) 2000-02-16
CA2279099A1 (fr) 2000-01-27
CN1122669C (zh) 2003-10-01
NO993608D0 (no) 1999-07-23
HUP9902546A3 (en) 2002-09-30
EP0982308B1 (fr) 2003-02-26

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse