FR2755699B1 - Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes - Google Patents
Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genesInfo
- Publication number
- FR2755699B1 FR2755699B1 FR9613691A FR9613691A FR2755699B1 FR 2755699 B1 FR2755699 B1 FR 2755699B1 FR 9613691 A FR9613691 A FR 9613691A FR 9613691 A FR9613691 A FR 9613691A FR 2755699 B1 FR2755699 B1 FR 2755699B1
- Authority
- FR
- France
- Prior art keywords
- inductible
- vectors
- targeted
- gene expression
- new constructions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000014509 gene expression Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9613691A FR2755699B1 (fr) | 1996-11-08 | 1996-11-08 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes |
KR1019990704102A KR20000053163A (ko) | 1996-11-08 | 1997-11-06 | 표적화된 유도가능한 유전자 발현을 위한 신규 작제물 및 벡터 |
SK614-99A SK61499A3 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
CZ991633A CZ163399A3 (cs) | 1996-11-08 | 1997-11-06 | Rekombinantní vektor pro cílenou a indukovanou expresi genů a farmaceutický přípravek obsahující takový vektor |
EP97913264A EP0946740A1 (fr) | 1996-11-08 | 1997-11-06 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes |
US09/297,910 US20020144302A1 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
JP52223498A JP2001503279A (ja) | 1996-11-08 | 1997-11-06 | ターゲットを定めて遺伝子を誘導発現させるための新規な構築物及びベクター |
BR9713981-5A BR9713981A (pt) | 1996-11-08 | 1997-11-06 | Vetor recombinante para a expressão induzìvel e hepatoespecìfica de uma molécula, adenovìrus recombinante, vetor adenoviral, variante do promotor do gene da apolipoproteìna aii humana, célula, composição farmacêutica, processo para produção de uma proteìna recombinante, e, utilização de um adenovìrus |
PCT/FR1997/001992 WO1998021349A1 (fr) | 1996-11-08 | 1997-11-06 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes |
HU9904235A HUP9904235A3 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
AU50578/98A AU5057898A (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
CA002269864A CA2269864A1 (fr) | 1996-11-08 | 1997-11-06 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes |
IL12959397A IL129593A0 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
ZA9710114A ZA9710114B (en) | 1996-11-08 | 1997-11-10 | Method for the expression of genes. |
NO992153A NO992153L (no) | 1996-11-08 | 1999-05-04 | Nye konstruktur og vektorer for mÕlstyrt og induktibel ekspresjon av gener |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9613691A FR2755699B1 (fr) | 1996-11-08 | 1996-11-08 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2755699A1 FR2755699A1 (fr) | 1998-05-15 |
FR2755699B1 true FR2755699B1 (fr) | 1998-12-18 |
Family
ID=9497481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9613691A Expired - Fee Related FR2755699B1 (fr) | 1996-11-08 | 1996-11-08 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes |
Country Status (15)
Country | Link |
---|---|
US (1) | US20020144302A1 (fr) |
EP (1) | EP0946740A1 (fr) |
JP (1) | JP2001503279A (fr) |
KR (1) | KR20000053163A (fr) |
AU (1) | AU5057898A (fr) |
BR (1) | BR9713981A (fr) |
CA (1) | CA2269864A1 (fr) |
CZ (1) | CZ163399A3 (fr) |
FR (1) | FR2755699B1 (fr) |
HU (1) | HUP9904235A3 (fr) |
IL (1) | IL129593A0 (fr) |
NO (1) | NO992153L (fr) |
SK (1) | SK61499A3 (fr) |
WO (1) | WO1998021349A1 (fr) |
ZA (1) | ZA9710114B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999005161A1 (fr) * | 1997-07-25 | 1999-02-04 | Ligand Pharmaceuticals Incorporated | SEQUENCES REGULATRICES DU GENE HUMAIN PPARη (RECEPTEUR GAMMA ACTIVE DE LA PROLIFERATION DES PEROXYSOMES) ET LEURS UTILISATIONS |
HUP0203584A2 (hu) * | 1999-06-22 | 2003-02-28 | Aventis Pharma S.A. | Nukleáris PPAR receptorokat alkalmazó expressziós szabályozó redszer |
FR2795425B1 (fr) * | 1999-06-22 | 2003-12-05 | Aventis Pharma Sa | Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands |
JP2003526368A (ja) * | 2000-03-14 | 2003-09-09 | ユニベルシテ・ピエール・エ・マリー・キユリー | 炎症により誘導可能なハイブリッドプロモーター、それらを含有するベクター、及びそれらの使用 |
FR2806418B1 (fr) | 2000-03-14 | 2004-07-16 | Aventis Pharma Sa | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
AU2002333682A1 (en) * | 2001-08-02 | 2003-02-17 | Gencell S.A. | Inducible expression systems employing ppar transcriptional activators |
EP1288303A1 (fr) * | 2001-08-23 | 2003-03-05 | Aventis Pharma S.A. | Systèmes d'expression inductibles utilisant PPAR comme activateurs transcriptionnels |
US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
US11306329B2 (en) | 2018-02-19 | 2022-04-19 | City Of Hope | Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof |
TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0516443A1 (fr) * | 1991-05-31 | 1992-12-02 | Eli Lilly And Company | Procédé et vecteurs pour essayer la régulation de la synthèse de l'apolipoprotéine AI |
FR2704556B1 (fr) * | 1993-04-30 | 1995-07-13 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
FR2718329B1 (fr) * | 1994-03-21 | 2002-09-20 | Rhone Poulenc Rorer Sa | Lapin transgénique sensibilisé aux dyslipoprotéinémies. |
FR2726285B1 (fr) * | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
-
1996
- 1996-11-08 FR FR9613691A patent/FR2755699B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-06 AU AU50578/98A patent/AU5057898A/en not_active Abandoned
- 1997-11-06 HU HU9904235A patent/HUP9904235A3/hu unknown
- 1997-11-06 KR KR1019990704102A patent/KR20000053163A/ko not_active Application Discontinuation
- 1997-11-06 CZ CZ991633A patent/CZ163399A3/cs unknown
- 1997-11-06 BR BR9713981-5A patent/BR9713981A/pt not_active IP Right Cessation
- 1997-11-06 IL IL12959397A patent/IL129593A0/xx unknown
- 1997-11-06 CA CA002269864A patent/CA2269864A1/fr not_active Abandoned
- 1997-11-06 EP EP97913264A patent/EP0946740A1/fr not_active Withdrawn
- 1997-11-06 JP JP52223498A patent/JP2001503279A/ja active Pending
- 1997-11-06 SK SK614-99A patent/SK61499A3/sk unknown
- 1997-11-06 WO PCT/FR1997/001992 patent/WO1998021349A1/fr not_active Application Discontinuation
- 1997-11-06 US US09/297,910 patent/US20020144302A1/en not_active Abandoned
- 1997-11-10 ZA ZA9710114A patent/ZA9710114B/xx unknown
-
1999
- 1999-05-04 NO NO992153A patent/NO992153L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FR2755699A1 (fr) | 1998-05-15 |
NO992153D0 (no) | 1999-05-04 |
CZ163399A3 (cs) | 1999-08-11 |
HUP9904235A2 (hu) | 2000-04-28 |
WO1998021349A1 (fr) | 1998-05-22 |
SK61499A3 (en) | 2000-02-14 |
IL129593A0 (en) | 2000-02-29 |
US20020144302A1 (en) | 2002-10-03 |
ZA9710114B (en) | 1998-06-08 |
NO992153L (no) | 1999-05-04 |
KR20000053163A (ko) | 2000-08-25 |
BR9713981A (pt) | 2000-05-02 |
AU5057898A (en) | 1998-06-03 |
EP0946740A1 (fr) | 1999-10-06 |
JP2001503279A (ja) | 2001-03-13 |
HUP9904235A3 (en) | 2003-03-28 |
CA2269864A1 (fr) | 1998-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |