IL129593A0 - Novel constructs and vectors for the targeted and inducible expression of genes - Google Patents
Novel constructs and vectors for the targeted and inducible expression of genesInfo
- Publication number
- IL129593A0 IL129593A0 IL12959397A IL12959397A IL129593A0 IL 129593 A0 IL129593 A0 IL 129593A0 IL 12959397 A IL12959397 A IL 12959397A IL 12959397 A IL12959397 A IL 12959397A IL 129593 A0 IL129593 A0 IL 129593A0
- Authority
- IL
- Israel
- Prior art keywords
- genes
- vectors
- targeted
- inducible expression
- novel constructs
- Prior art date
Links
- 230000001939 inductive effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9613691A FR2755699B1 (fr) | 1996-11-08 | 1996-11-08 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes |
| PCT/FR1997/001992 WO1998021349A1 (fr) | 1996-11-08 | 1997-11-06 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible de genes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL129593A0 true IL129593A0 (en) | 2000-02-29 |
Family
ID=9497481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12959397A IL129593A0 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20020144302A1 (xx) |
| EP (1) | EP0946740A1 (xx) |
| JP (1) | JP2001503279A (xx) |
| KR (1) | KR20000053163A (xx) |
| AU (1) | AU5057898A (xx) |
| BR (1) | BR9713981A (xx) |
| CA (1) | CA2269864A1 (xx) |
| CZ (1) | CZ163399A3 (xx) |
| FR (1) | FR2755699B1 (xx) |
| HU (1) | HUP9904235A3 (xx) |
| IL (1) | IL129593A0 (xx) |
| NO (1) | NO992153D0 (xx) |
| SK (1) | SK61499A3 (xx) |
| WO (1) | WO1998021349A1 (xx) |
| ZA (1) | ZA9710114B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7098025B1 (en) | 1997-07-25 | 2006-08-29 | Ligand Pharmaceuticals Incorporated | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor |
| CN1370240A (zh) * | 1999-06-22 | 2002-09-18 | 阿文蒂斯药物股份有限公司 | 利用ppar核受体的表达调节系统 |
| FR2795425B1 (fr) * | 1999-06-22 | 2003-12-05 | Aventis Pharma Sa | Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands |
| WO2001068845A2 (fr) * | 2000-03-14 | 2001-09-20 | Universite Pierre Et Marie Curie | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
| FR2806418B1 (fr) * | 2000-03-14 | 2004-07-16 | Aventis Pharma Sa | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
| EP1288303A1 (en) * | 2001-08-23 | 2003-03-05 | Aventis Pharma S.A. | Inducible expression systems employing PPAR transcriptional activators |
| AU2002333682A1 (en) * | 2001-08-02 | 2003-02-17 | Gencell S.A. | Inducible expression systems employing ppar transcriptional activators |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| EP3755795A4 (en) | 2018-02-19 | 2022-07-20 | Homology Medicines, Inc. | ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RECOVERING F8 GENE FUNCTION AND METHODS OF USE THEREOF |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0516443A1 (en) * | 1991-05-31 | 1992-12-02 | Eli Lilly And Company | Vectors and methods for assaying the regulation of apolipoprotein ai synthesis |
| FR2704556B1 (fr) * | 1993-04-30 | 1995-07-13 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
| FR2718329B1 (fr) * | 1994-03-21 | 2002-09-20 | Rhone Poulenc Rorer Sa | Lapin transgénique sensibilisé aux dyslipoprotéinémies. |
| FR2726285B1 (fr) * | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
-
1996
- 1996-11-08 FR FR9613691A patent/FR2755699B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-06 SK SK614-99A patent/SK61499A3/sk unknown
- 1997-11-06 KR KR1019990704102A patent/KR20000053163A/ko not_active Application Discontinuation
- 1997-11-06 CZ CZ991633A patent/CZ163399A3/cs unknown
- 1997-11-06 AU AU50578/98A patent/AU5057898A/en not_active Abandoned
- 1997-11-06 CA CA002269864A patent/CA2269864A1/fr not_active Abandoned
- 1997-11-06 HU HU9904235A patent/HUP9904235A3/hu unknown
- 1997-11-06 JP JP52223498A patent/JP2001503279A/ja active Pending
- 1997-11-06 WO PCT/FR1997/001992 patent/WO1998021349A1/fr not_active Application Discontinuation
- 1997-11-06 EP EP97913264A patent/EP0946740A1/fr not_active Withdrawn
- 1997-11-06 US US09/297,910 patent/US20020144302A1/en not_active Abandoned
- 1997-11-06 IL IL12959397A patent/IL129593A0/xx unknown
- 1997-11-06 BR BR9713981-5A patent/BR9713981A/pt not_active IP Right Cessation
- 1997-11-10 ZA ZA9710114A patent/ZA9710114B/xx unknown
-
1999
- 1999-05-04 NO NO992153A patent/NO992153D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9710114B (en) | 1998-06-08 |
| FR2755699B1 (fr) | 1998-12-18 |
| HUP9904235A3 (en) | 2003-03-28 |
| CZ163399A3 (cs) | 1999-08-11 |
| WO1998021349A1 (fr) | 1998-05-22 |
| EP0946740A1 (fr) | 1999-10-06 |
| BR9713981A (pt) | 2000-05-02 |
| SK61499A3 (en) | 2000-02-14 |
| AU5057898A (en) | 1998-06-03 |
| NO992153L (no) | 1999-05-04 |
| FR2755699A1 (fr) | 1998-05-15 |
| KR20000053163A (ko) | 2000-08-25 |
| US20020144302A1 (en) | 2002-10-03 |
| NO992153D0 (no) | 1999-05-04 |
| CA2269864A1 (fr) | 1998-05-22 |
| HUP9904235A2 (hu) | 2000-04-28 |
| JP2001503279A (ja) | 2001-03-13 |
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