FR2795425B1 - Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands - Google Patents

Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands

Info

Publication number
FR2795425B1
FR2795425B1 FR9907957A FR9907957A FR2795425B1 FR 2795425 B1 FR2795425 B1 FR 2795425B1 FR 9907957 A FR9907957 A FR 9907957A FR 9907957 A FR9907957 A FR 9907957A FR 2795425 B1 FR2795425 B1 FR 2795425B1
Authority
FR
France
Prior art keywords
ligands
expression system
nuclear receptors
pharmacological regulation
pharmacological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9907957A
Other languages
English (en)
Other versions
FR2795425A1 (fr
Inventor
Raphael Darteil
Joel Crouzet
Bart Staels
Abderrahim Mahfoudi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9907957A priority Critical patent/FR2795425B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to BR0011897-4A priority patent/BR0011897A/pt
Priority to AU61645/00A priority patent/AU6164500A/en
Priority to CA002375869A priority patent/CA2375869A1/fr
Priority to HU0203584A priority patent/HUP0203584A2/hu
Priority to PCT/FR2000/001744 priority patent/WO2000078986A1/fr
Priority to NZ516678A priority patent/NZ516678A/en
Priority to CN00811928A priority patent/CN1370240A/zh
Priority to PL00353031A priority patent/PL353031A1/xx
Priority to CZ20014609A priority patent/CZ20014609A3/cs
Priority to EP00948058A priority patent/EP1190084A1/fr
Priority to IL14710400A priority patent/IL147104A0/xx
Priority to JP2001505726A priority patent/JP2003503034A/ja
Priority to MXPA01013227A priority patent/MXPA01013227A/es
Priority to KR1020017016447A priority patent/KR20020028909A/ko
Publication of FR2795425A1 publication Critical patent/FR2795425A1/fr
Priority to NO20016347A priority patent/NO20016347L/no
Priority to ZA200200024A priority patent/ZA200200024B/en
Application granted granted Critical
Publication of FR2795425B1 publication Critical patent/FR2795425B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9907957A 1999-06-22 1999-06-22 Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands Expired - Fee Related FR2795425B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR9907957A FR2795425B1 (fr) 1999-06-22 1999-06-22 Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands
JP2001505726A JP2003503034A (ja) 1999-06-22 2000-06-22 核内ｐｐａｒレセプターを使用する発現調節システム
CA002375869A CA2375869A1 (fr) 1999-06-22 2000-06-22 Systeme de regulation de l'expression utilisant les recepteurs nucleaires ppar
HU0203584A HUP0203584A2 (hu) 1999-06-22 2000-06-22 Nukleáris PPAR receptorokat alkalmazó expressziós szabályozó redszer
PCT/FR2000/001744 WO2000078986A1 (fr) 1999-06-22 2000-06-22 Systeme de regulation de l'expression utilisant les recepteurs nucleaires ppar
NZ516678A NZ516678A (en) 1999-06-22 2000-06-22 Regulation system of expression using nuclear PPAR receptors
CN00811928A CN1370240A (zh) 1999-06-22 2000-06-22 利用ppar核受体的表达调节系统
PL00353031A PL353031A1 (en) 1999-06-22 2000-06-22 Regulation system of expression using nuclear ppar receptors
BR0011897-4A BR0011897A (pt) 1999-06-22 2000-06-22 Composição, vetor, utilização de uma composição, processos para expressão regulada de um ácido nucleico em uma célula, para regulação da expressão de um ácido nucleico e para identificação de ligandos dos ppar, célula, ppar modificado, e, ácido nucleico
EP00948058A EP1190084A1 (fr) 1999-06-22 2000-06-22 Systeme de regulation de l'expression utilisant les recepteurs nucleaires ppar
IL14710400A IL147104A0 (en) 1999-06-22 2000-06-22 Regulation system of expression using nuclear ppar receptors
AU61645/00A AU6164500A (en) 1999-06-22 2000-06-22 Regulation system of expression using nuclear ppar receptors
MXPA01013227A MXPA01013227A (es) 1999-06-22 2000-06-22 Sistema de regulacion farmacologica de la expresion que utiliza los receptores nucleares ppar y sus legandos.
KR1020017016447A KR20020028909A (ko) 1999-06-22 2000-06-22 핵 피피에이알 수용체를 이용한 발현 조절 시스템
CZ20014609A CZ20014609A3 (cs) 1999-06-22 2000-06-22 Kompozice obsahující nukleovou kyselinu kódující jaderný receptor PPAR a její pouľití pro regulaci exprese
NO20016347A NO20016347L (no) 1999-06-22 2001-12-21 Reguleringssystem for ekspresjon ved anvendelse av nukle¶re PPAR-reseptorer og deres ligander
ZA200200024A ZA200200024B (en) 1999-06-22 2002-01-02 Regulation system of expression using nuclear PPAR receptors.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907957A FR2795425B1 (fr) 1999-06-22 1999-06-22 Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands

Publications (2)

Publication Number Publication Date
FR2795425A1 FR2795425A1 (fr) 2000-12-29
FR2795425B1 true FR2795425B1 (fr) 2003-12-05

Family

ID=9547159

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9907957A Expired - Fee Related FR2795425B1 (fr) 1999-06-22 1999-06-22 Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands

Country Status (3)

Country Link
FR (1) FR2795425B1 (fr)
PL (1) PL353031A1 (fr)
ZA (1) ZA200200024B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10502256A (ja) * 1994-07-01 1998-03-03 ザ ソールク インスチチュート フォア バイオロジカル スタディズ 哺乳動物のペルオキシソーム増殖物質活性化受容体およびその使用
FR2755699B1 (fr) * 1996-11-08 1998-12-18 Rhone Poulenc Rorer Sa Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Also Published As

Publication number Publication date
ZA200200024B (en) 2003-04-02
PL353031A1 (en) 2003-10-06
FR2795425A1 (fr) 2000-12-29

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