HUP9904235A3 - Novel constructs and vectors for the targeted and inducible expression of genes - Google Patents

Novel constructs and vectors for the targeted and inducible expression of genes

Info

Publication number
HUP9904235A3
HUP9904235A3 HU9904235A HUP9904235A HUP9904235A3 HU P9904235 A3 HUP9904235 A3 HU P9904235A3 HU 9904235 A HU9904235 A HU 9904235A HU P9904235 A HUP9904235 A HU P9904235A HU P9904235 A3 HUP9904235 A3 HU P9904235A3
Authority
HU
Hungary
Prior art keywords
genes
vectors
targeted
inducible expression
novel constructs
Prior art date
Application number
HU9904235A
Other languages
English (en)
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of HUP9904235A2 publication Critical patent/HUP9904235A2/hu
Publication of HUP9904235A3 publication Critical patent/HUP9904235A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9904235A 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes HUP9904235A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613691A FR2755699B1 (fr) 1996-11-08 1996-11-08 Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Publications (2)

Publication Number Publication Date
HUP9904235A2 HUP9904235A2 (hu) 2000-04-28
HUP9904235A3 true HUP9904235A3 (en) 2003-03-28

Family

ID=9497481

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904235A HUP9904235A3 (en) 1996-11-08 1997-11-06 Novel constructs and vectors for the targeted and inducible expression of genes

Country Status (15)

Country Link
US (1) US20020144302A1 (hu)
EP (1) EP0946740A1 (hu)
JP (1) JP2001503279A (hu)
KR (1) KR20000053163A (hu)
AU (1) AU5057898A (hu)
BR (1) BR9713981A (hu)
CA (1) CA2269864A1 (hu)
CZ (1) CZ163399A3 (hu)
FR (1) FR2755699B1 (hu)
HU (1) HUP9904235A3 (hu)
IL (1) IL129593A0 (hu)
NO (1) NO992153L (hu)
SK (1) SK61499A3 (hu)
WO (1) WO1998021349A1 (hu)
ZA (1) ZA9710114B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
AU6164500A (en) * 1999-06-22 2001-01-09 Aventis Pharma S.A. Regulation system of expression using nuclear ppar receptors
FR2795425B1 (fr) * 1999-06-22 2003-12-05 Aventis Pharma Sa Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands
FR2806418B1 (fr) * 2000-03-14 2004-07-16 Aventis Pharma Sa Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
CA2403189A1 (fr) * 2000-03-14 2001-09-20 Charbel Massaad Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
WO2003012113A2 (en) * 2001-08-02 2003-02-13 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
EP1288303A1 (en) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Inducible expression systems employing PPAR transcriptional activators
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
CN112041437A (zh) 2018-02-19 2020-12-04 同源药物公司 用于恢复f8基因功能的腺相关病毒组合物和其使用方法
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0516443A1 (en) * 1991-05-31 1992-12-02 Eli Lilly And Company Vectors and methods for assaying the regulation of apolipoprotein ai synthesis
FR2704556B1 (fr) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2718329B1 (fr) * 1994-03-21 2002-09-20 Rhone Poulenc Rorer Sa Lapin transgénique sensibilisé aux dyslipoprotéinémies.
FR2726285B1 (fr) * 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation

Also Published As

Publication number Publication date
NO992153D0 (no) 1999-05-04
US20020144302A1 (en) 2002-10-03
IL129593A0 (en) 2000-02-29
FR2755699B1 (fr) 1998-12-18
JP2001503279A (ja) 2001-03-13
HUP9904235A2 (hu) 2000-04-28
NO992153L (no) 1999-05-04
FR2755699A1 (fr) 1998-05-15
WO1998021349A1 (fr) 1998-05-22
SK61499A3 (en) 2000-02-14
ZA9710114B (en) 1998-06-08
BR9713981A (pt) 2000-05-02
KR20000053163A (ko) 2000-08-25
CA2269864A1 (fr) 1998-05-22
CZ163399A3 (cs) 1999-08-11
AU5057898A (en) 1998-06-03
EP0946740A1 (fr) 1999-10-06

Similar Documents

Publication Publication Date Title
AU9319198A (en) Methods and vector constructs useful for production of recombinant aav
HUP0001650A3 (en) Improved expression vectors
IL122446A0 (en) Cloning and expression of thermostable muts genes and proteins and uses therefor
IL115107A0 (en) Nucleotide sequences of acp thioesterase genes and their use
AU6037199A (en) Rac-like genes from maize and methods of use
HUP9700428A3 (en) Targetcell-specific vectors for inserting genes, pharmaceuticals comprising such vectors and their use
AU2678097A (en) Targeted viral vectors
AU7435296A (en) Novel expression vectors and methods of use
AUPP249298A0 (en) Synthetic genes and genetic constructs comprising same I
EP0912594A4 (en) IDENTIFICATION OF ESSENTIAL GENES FOR SURVIVAL
IL129593A0 (en) Novel constructs and vectors for the targeted and inducible expression of genes
IL135943A0 (en) Hyperthermic inducible expression vectors for gene theraphy and methods of use thereof
ZA982568B (en) The specificity of gene expression.
GB9516059D0 (en) Novel genes and proteins
GB2305920B (en) Antitumour vector constructs and methods
AU2408397A (en) Ob protein receptor genes and use of the same
ZA981948B (en) Photodynamic Therapy Generated Oxidative Stress for Temporal and Selective Expression of Heterologous Genes.
EP1005360A4 (en) ANTI-OXIDANT PROTEIN 2, GENE AND METHODS OF USE THEREOF
ZA975793B (en) Isolation of cloning of the human harsa-l gene and uses thereof
HUP0001909A3 (en) Plant gene constructs and their use
GB9701975D0 (en) Targeting of stress inducible genes
FR2743818B1 (fr) Constructions d'adn et vecteurs d'expression derives du gene de l'arn va i d'adenovirus
GB9520079D0 (en) Antitumour vector constructs and methods
HU9402847D0 (en) Cloning and expression of the ketosteroid-dehydrogenasie gene
GB9719787D0 (en) Dna cloning vectors and methods