FR2676443B1 - Nouveaux derives de perhydroisoindole et leur preparation. - Google Patents

Nouveaux derives de perhydroisoindole et leur preparation.

Info

Publication number
FR2676443B1
FR2676443B1 FR9106036A FR9106036A FR2676443B1 FR 2676443 B1 FR2676443 B1 FR 2676443B1 FR 9106036 A FR9106036 A FR 9106036A FR 9106036 A FR9106036 A FR 9106036A FR 2676443 B1 FR2676443 B1 FR 2676443B1
Authority
FR
France
Prior art keywords
preparation
halogen atom
symbol
perhydroisoindole derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9106036A
Other languages
English (en)
French (fr)
Other versions
FR2676443A1 (fr
Inventor
Achard Daniel
Grisoni Serge
Hannessian Stephen
Moutonnier Claude
Peyronel Jean-Francois
Tabart Michel
Truchon Alain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to FR9106036A priority Critical patent/FR2676443B1/fr
Priority to CS932448A priority patent/CZ244893A3/cs
Priority to IL101867A priority patent/IL101867A0/xx
Priority to DK92911071.6T priority patent/DK0586471T3/da
Priority to NZ242773A priority patent/NZ242773A/xx
Priority to PCT/FR1992/000430 priority patent/WO1992020654A1/fr
Priority to DE69201058T priority patent/DE69201058T2/de
Priority to HU9303250A priority patent/HUT68913A/hu
Priority to ZA923541A priority patent/ZA923541B/xx
Priority to EP92911071A priority patent/EP0586471B1/fr
Priority to JP4510463A priority patent/JPH06507628A/ja
Priority to CA002109297A priority patent/CA2109297A1/fr
Priority to YU51692A priority patent/YU51692A/sh
Priority to US08/146,142 priority patent/US5508433A/en
Priority to AU18840/92A priority patent/AU1884092A/en
Priority to AT92911071T priority patent/ATE116295T1/de
Priority to EP92401330A priority patent/EP0514274A1/fr
Priority to TW081103793A priority patent/TW226991B/zh
Priority to FI935072A priority patent/FI935072A0/fi
Priority to MX9202288A priority patent/MX9202288A/es
Priority to SK1268-93A priority patent/SK126893A3/sk
Priority to ES92911071T priority patent/ES2066620T3/es
Priority to IE157992A priority patent/IE921579A1/en
Publication of FR2676443A1 publication Critical patent/FR2676443A1/fr
Application granted granted Critical
Publication of FR2676443B1 publication Critical patent/FR2676443B1/fr
Priority to NO1993933976A priority patent/NO933976D0/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9106036A 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation. Expired - Lifetime FR2676443B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
CS932448A CZ244893A3 (en) 1991-05-17 1992-05-12 Novel perhydroisoindole derivatives, and process for preparing thereof
IL101867A IL101867A0 (en) 1991-05-17 1992-05-14 Perhydroisoindole derivatives and their preparation
EP92401330A EP0514274A1 (fr) 1991-05-17 1992-05-15 Nouveaux dérivés de perhydroisoindole et leur préparation
PCT/FR1992/000430 WO1992020654A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation
DE69201058T DE69201058T2 (de) 1991-05-17 1992-05-15 Perhydroisoindol derivate und ihre herstellung.
HU9303250A HUT68913A (en) 1991-05-17 1992-05-15 Novel derivatives of perhydroisoindole and preparation thereof
ZA923541A ZA923541B (en) 1991-05-17 1992-05-15 New perhydroisoindole derivatives and their preparation
EP92911071A EP0586471B1 (fr) 1991-05-17 1992-05-15 Derives de perhydroisoindole et leur preparation
JP4510463A JPH06507628A (ja) 1991-05-17 1992-05-15 新規ペルヒドロイソインドール誘導体及びその製造
CA002109297A CA2109297A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation
YU51692A YU51692A (sh) 1991-05-17 1992-05-15 Novi derivati perhidroizoindola i njihovo dobijanje
DK92911071.6T DK0586471T3 (da) 1991-05-17 1992-05-15 Perhydroisoindolderivater og deres fremstilling
AU18840/92A AU1884092A (en) 1991-05-17 1992-05-15 Novel derivatives of perhydroisoindole and preparation thereof
AT92911071T ATE116295T1 (de) 1991-05-17 1992-05-15 Perhydroisoindol derivate und ihre herstellung.
NZ242773A NZ242773A (en) 1991-05-17 1992-05-15 4,4-diphenylisoindole derivatives
TW081103793A TW226991B (OSRAM) 1991-05-17 1992-05-15
FI935072A FI935072A0 (fi) 1991-05-17 1992-05-15 Nya perhydroisoindoler och deras framstaellning
MX9202288A MX9202288A (es) 1991-05-17 1992-05-15 Nuevos derivados de per hidro iso indol y procedimiento para su preparacion.
SK1268-93A SK126893A3 (en) 1991-05-17 1992-05-15 Derivatives of perhydroisoindole and preparation thereof
ES92911071T ES2066620T3 (es) 1991-05-17 1992-05-15 Nuevos derivados de perhidroisoindol y su preparacion.
US08/146,142 US5508433A (en) 1991-05-17 1992-05-15 Derivatives of perhydroisoindole and preparation thereof
IE157992A IE921579A1 (en) 1991-05-17 1992-07-01 New perhydroisoindole derivatives and their preparation
NO1993933976A NO933976D0 (no) 1991-05-17 1993-11-03 Nye perhydroisoindolderivater og deres fremstilling

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.

Publications (2)

Publication Number Publication Date
FR2676443A1 FR2676443A1 (fr) 1992-11-20
FR2676443B1 true FR2676443B1 (fr) 1993-08-06

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9106036A Expired - Lifetime FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.

Country Status (23)

Country Link
US (1) US5508433A (OSRAM)
EP (2) EP0586471B1 (OSRAM)
JP (1) JPH06507628A (OSRAM)
AT (1) ATE116295T1 (OSRAM)
AU (1) AU1884092A (OSRAM)
CA (1) CA2109297A1 (OSRAM)
CZ (1) CZ244893A3 (OSRAM)
DE (1) DE69201058T2 (OSRAM)
DK (1) DK0586471T3 (OSRAM)
ES (1) ES2066620T3 (OSRAM)
FI (1) FI935072A0 (OSRAM)
FR (1) FR2676443B1 (OSRAM)
HU (1) HUT68913A (OSRAM)
IE (1) IE921579A1 (OSRAM)
IL (1) IL101867A0 (OSRAM)
MX (1) MX9202288A (OSRAM)
NO (1) NO933976D0 (OSRAM)
NZ (1) NZ242773A (OSRAM)
SK (1) SK126893A3 (OSRAM)
TW (1) TW226991B (OSRAM)
WO (1) WO1992020654A1 (OSRAM)
YU (1) YU51692A (OSRAM)
ZA (1) ZA923541B (OSRAM)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
PT1246806E (pt) 1999-11-03 2008-04-03 Amr Technology Inc Tetra-hidroisoquinolinas aril- e heteroaril-substituídas e sua utilização no bloqueio da recaptação de norepinefrina, dopamina e serotonina.
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
US7541357B2 (en) 2004-07-15 2009-06-02 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
EP1904069B1 (en) 2005-07-15 2018-06-13 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
DK2805945T3 (da) 2007-01-10 2019-07-15 Msd Italia Srl Amid-substituerede indazoler som poly(adp-ribose)polymerase- (parp) hæmmere
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
CA2760837C (en) 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
PH12012500713A1 (en) 2009-10-14 2012-11-26 Merck Sharp & Dohme Substituted piperidines that increase p53 activity and the uses thereof
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
RU2624045C2 (ru) 2010-08-17 2017-06-30 Сирна Терапьютикс,Инк ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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ME02925B (me) 2012-11-28 2018-04-20 Merck Sharp & Dohme Kompozicije i postupci za liječenje kancera
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WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
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US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
NO933976L (no) 1993-11-03
MX9202288A (es) 1992-11-01
AU1884092A (en) 1992-12-30
IL101867A0 (en) 1992-12-30
NZ242773A (en) 1994-06-27
CA2109297A1 (fr) 1992-11-18
DK0586471T3 (da) 1995-06-06
WO1992020654A1 (fr) 1992-11-26
CZ244893A3 (en) 1994-04-13
DE69201058D1 (de) 1995-02-09
FI935072L (fi) 1993-11-16
FR2676443A1 (fr) 1992-11-20
ZA923541B (en) 1993-01-27
EP0586471A1 (fr) 1994-03-16
FI935072A7 (fi) 1993-11-16
YU51692A (sh) 1994-06-10
ATE116295T1 (de) 1995-01-15
HUT68913A (en) 1995-08-28
JPH06507628A (ja) 1994-09-01
NO933976D0 (no) 1993-11-03
EP0514274A1 (fr) 1992-11-19
IE921579A1 (en) 1992-11-18
HU9303250D0 (en) 1994-03-28
FI935072A0 (fi) 1993-11-16
SK126893A3 (en) 1994-11-09
US5508433A (en) 1996-04-16
TW226991B (OSRAM) 1994-07-21
DE69201058T2 (de) 1995-05-11
EP0586471B1 (fr) 1994-12-28
ES2066620T3 (es) 1995-03-01

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