AU1884092A - Novel derivatives of perhydroisoindole and preparation thereof - Google Patents

Novel derivatives of perhydroisoindole and preparation thereof

Info

Publication number
AU1884092A
AU1884092A AU18840/92A AU1884092A AU1884092A AU 1884092 A AU1884092 A AU 1884092A AU 18840/92 A AU18840/92 A AU 18840/92A AU 1884092 A AU1884092 A AU 1884092A AU 1884092 A AU1884092 A AU 1884092A
Authority
AU
Australia
Prior art keywords
preparation
halogen atom
perhydroisoindole
symbol
novel derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU18840/92A
Other languages
English (en)
Inventor
Daniel Achard
Serge Grisoni
Stephen Hanessian
Claude Moutonnier
Jean-Francois Peyronel
Michel Tabart
Alain Truchon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of AU1884092A publication Critical patent/AU1884092A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU18840/92A 1991-05-17 1992-05-15 Novel derivatives of perhydroisoindole and preparation thereof Abandoned AU1884092A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
FR9106036 1991-05-17

Publications (1)

Publication Number Publication Date
AU1884092A true AU1884092A (en) 1992-12-30

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18840/92A Abandoned AU1884092A (en) 1991-05-17 1992-05-15 Novel derivatives of perhydroisoindole and preparation thereof

Country Status (23)

Country Link
US (1) US5508433A (OSRAM)
EP (2) EP0586471B1 (OSRAM)
JP (1) JPH06507628A (OSRAM)
AT (1) ATE116295T1 (OSRAM)
AU (1) AU1884092A (OSRAM)
CA (1) CA2109297A1 (OSRAM)
CZ (1) CZ244893A3 (OSRAM)
DE (1) DE69201058T2 (OSRAM)
DK (1) DK0586471T3 (OSRAM)
ES (1) ES2066620T3 (OSRAM)
FI (1) FI935072A0 (OSRAM)
FR (1) FR2676443B1 (OSRAM)
HU (1) HUT68913A (OSRAM)
IE (1) IE921579A1 (OSRAM)
IL (1) IL101867A0 (OSRAM)
MX (1) MX9202288A (OSRAM)
NO (1) NO933976D0 (OSRAM)
NZ (1) NZ242773A (OSRAM)
SK (1) SK126893A3 (OSRAM)
TW (1) TW226991B (OSRAM)
WO (1) WO1992020654A1 (OSRAM)
YU (1) YU51692A (OSRAM)
ZA (1) ZA923541B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674746B2 (en) * 1993-03-26 1997-01-09 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
PT1246806E (pt) 1999-11-03 2008-04-03 Amr Technology Inc Tetra-hidroisoquinolinas aril- e heteroaril-substituídas e sua utilização no bloqueio da recaptação de norepinefrina, dopamina e serotonina.
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
US7541357B2 (en) 2004-07-15 2009-06-02 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
EP1904069B1 (en) 2005-07-15 2018-06-13 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
DK2805945T3 (da) 2007-01-10 2019-07-15 Msd Italia Srl Amid-substituerede indazoler som poly(adp-ribose)polymerase- (parp) hæmmere
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
CA2760837C (en) 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
PH12012500713A1 (en) 2009-10-14 2012-11-26 Merck Sharp & Dohme Substituted piperidines that increase p53 activity and the uses thereof
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
RU2624045C2 (ru) 2010-08-17 2017-06-30 Сирна Терапьютикс,Инк ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3327125B1 (en) 2010-10-29 2020-08-05 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
JP2014514321A (ja) 2011-04-21 2014-06-19 メルク・シャープ・アンド・ドーム・コーポレーション インスリン様増殖因子１受容体阻害剤
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP3358013B1 (en) 2012-05-02 2020-06-24 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
US9233979B2 (en) 2012-09-28 2016-01-12 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
ME02925B (me) 2012-11-28 2018-04-20 Merck Sharp & Dohme Kompozicije i postupci za liječenje kancera
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
AU2019317549A1 (en) 2018-08-07 2021-02-25 Msd International Gmbh PRMT5 inhibitors
EP3833668B1 (en) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674746B2 (en) * 1993-03-26 1997-01-09 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics

Also Published As

Publication number Publication date
NO933976L (no) 1993-11-03
MX9202288A (es) 1992-11-01
IL101867A0 (en) 1992-12-30
NZ242773A (en) 1994-06-27
CA2109297A1 (fr) 1992-11-18
DK0586471T3 (da) 1995-06-06
WO1992020654A1 (fr) 1992-11-26
CZ244893A3 (en) 1994-04-13
DE69201058D1 (de) 1995-02-09
FI935072L (fi) 1993-11-16
FR2676443B1 (fr) 1993-08-06
FR2676443A1 (fr) 1992-11-20
ZA923541B (en) 1993-01-27
EP0586471A1 (fr) 1994-03-16
FI935072A7 (fi) 1993-11-16
YU51692A (sh) 1994-06-10
ATE116295T1 (de) 1995-01-15
HUT68913A (en) 1995-08-28
JPH06507628A (ja) 1994-09-01
NO933976D0 (no) 1993-11-03
EP0514274A1 (fr) 1992-11-19
IE921579A1 (en) 1992-11-18
HU9303250D0 (en) 1994-03-28
FI935072A0 (fi) 1993-11-16
SK126893A3 (en) 1994-11-09
US5508433A (en) 1996-04-16
TW226991B (OSRAM) 1994-07-21
DE69201058T2 (de) 1995-05-11
EP0586471B1 (fr) 1994-12-28
ES2066620T3 (es) 1995-03-01

Similar Documents

Publication Publication Date Title
AU1884092A (en) Novel derivatives of perhydroisoindole and preparation thereof
MX9202287A (es) Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
AU635984B2 (en) New isoindolone derivatives and their preparation
GR3033996T3 (en) 3-(Piperi-4-yl) 1,2-benzisoxazole and 3-(piperazin-4-yl) 1,2-benzisoxazole derivatives, processes for their preparation and pharmaceutical compositions containing them
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
DK0700914T3 (da) Campththecinderivater, deres fremstilling og antitumormidler
DE69104075D1 (de) Mesomorphe Verbindung, sie enthaltende flüssigkristalline Zusammensetzung, sie verwendende flüssigkristalline Vorrichtung und Anzeigeapparat.
AU3286184A (en) 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
GR3003963T3 (OSRAM)
DK0538100T3 (da) Fremgangsmåde til fremstilling af derivater af fluorquinolin-3-carboxylsyre
ES469576A1 (es) Procedimiento para la preparacion de 5-alquilsulfonil- y 5- alquenilsulfonil-barbituricos.
RU93058289A (ru) Производные пергидроизоиндола, способы их получения