FR2653117A1 - Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant. - Google Patents

Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant. Download PDF

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Publication number
FR2653117A1
FR2653117A1 FR8913456A FR8913456A FR2653117A1 FR 2653117 A1 FR2653117 A1 FR 2653117A1 FR 8913456 A FR8913456 A FR 8913456A FR 8913456 A FR8913456 A FR 8913456A FR 2653117 A1 FR2653117 A1 FR 2653117A1
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France
Prior art keywords
derivatives
treatment
cells
prevention
lesions
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Granted
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FR8913456A
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English (en)
French (fr)
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FR2653117B1 (enExample
Inventor
Borg Jacques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medafor
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Medafor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR8913456A priority Critical patent/FR2653117A1/fr
Application filed by Medafor filed Critical Medafor
Priority to JP2514784A priority patent/JPH04502167A/ja
Priority to DE69026496T priority patent/DE69026496D1/de
Priority to AT90916133T priority patent/ATE136540T1/de
Priority to PCT/FR1990/000742 priority patent/WO1991005754A2/fr
Priority to US07/720,816 priority patent/US5243094A/en
Priority to CA002044162A priority patent/CA2044162A1/fr
Priority to EP90916133A priority patent/EP0448697B1/fr
Publication of FR2653117A1 publication Critical patent/FR2653117A1/fr
Priority to US08/027,034 priority patent/US5447959A/en
Application granted granted Critical
Publication of FR2653117B1 publication Critical patent/FR2653117B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C07C33/025—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C07C33/025—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond
    • C07C33/035—Alkenediols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/225—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8913456A 1989-10-13 1989-10-13 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant. Granted FR2653117A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR8913456A FR2653117A1 (fr) 1989-10-13 1989-10-13 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant.
DE69026496T DE69026496D1 (de) 1989-10-13 1990-10-15 Analoge von vitamin a und ihre verwendung, insbesondere als cytotrophische und cytoprotective substanzen sowie diese substanzen enthaltende arzneimittel
AT90916133T ATE136540T1 (de) 1989-10-13 1990-10-15 Analoge von vitamin a und ihre verwendung, insbesondere als cytotrophische und cytoprotective substanzen sowie diese substanzen enthaltende arzneimittel
PCT/FR1990/000742 WO1991005754A2 (fr) 1989-10-13 1990-10-15 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant
JP2514784A JPH04502167A (ja) 1989-10-13 1990-10-15 長鎖脂肪アルコール誘導体、特に細胞栄養分子及び細胞保護分子としてのその使用、並びに、該誘導体を含有する医薬組成物
US07/720,816 US5243094A (en) 1989-10-13 1990-10-15 Derivatives of long chain fatty alcohols, their uses, particularly as cytotrophic and cytoprotective molecules, and pharmaceutical compositions containing them
CA002044162A CA2044162A1 (fr) 1989-10-13 1990-10-15 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophes et cytoprotectrices, et compositions pharmaceutiques les contenant
EP90916133A EP0448697B1 (fr) 1989-10-13 1990-10-15 Analogues de la vitamine a, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant
US08/027,034 US5447959A (en) 1989-10-13 1993-03-05 Method of using derivatives of long chain fatty alcohols to treat neuronal degradation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913456A FR2653117A1 (fr) 1989-10-13 1989-10-13 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
FR2653117A1 true FR2653117A1 (fr) 1991-04-19
FR2653117B1 FR2653117B1 (enExample) 1994-07-13

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Application Number Title Priority Date Filing Date
FR8913456A Granted FR2653117A1 (fr) 1989-10-13 1989-10-13 Derives des alcools gras a longue chaine, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant.

Country Status (1)

Country Link
FR (1) FR2653117A1 (enExample)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2023129A1 (de) * 1970-05-05 1971-12-02 Schering Ag Neue Triacyloxymethal-acetoxysteroide
DE2551914A1 (de) * 1975-11-19 1977-06-02 Hoechst Ag Verfahren zur darstellung symmetrischer carotinoide
DE2459985B2 (de) * 1974-01-30 1979-02-15 The Lion Dentifrice Co., Ltd., Tokio Phosphorsäureester des Cholestanols und des Epicholestanols und deren Salze, Verfahren zur Herstellung derselben und antiphlogistische Mittel mit einem Gehalt derselben
EP0098620A2 (en) * 1980-05-30 1984-01-18 Eisai Co., Ltd. Alpha,beta-dihydropolyprenyl derivatives and a process for preparing these derivatives
DE3237632A1 (de) * 1982-10-11 1984-04-12 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung langkettiger linearer wachsalkohole
EP0105404A1 (en) * 1982-09-30 1984-04-18 Merck & Co. Inc. Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation
WO1984001899A1 (fr) * 1982-11-16 1984-05-24 Georges Motschan Nouvelle utilisation d'une vitamine unique ou d'une combinaison de diverses vitamines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2023129A1 (de) * 1970-05-05 1971-12-02 Schering Ag Neue Triacyloxymethal-acetoxysteroide
DE2459985B2 (de) * 1974-01-30 1979-02-15 The Lion Dentifrice Co., Ltd., Tokio Phosphorsäureester des Cholestanols und des Epicholestanols und deren Salze, Verfahren zur Herstellung derselben und antiphlogistische Mittel mit einem Gehalt derselben
DE2551914A1 (de) * 1975-11-19 1977-06-02 Hoechst Ag Verfahren zur darstellung symmetrischer carotinoide
EP0098620A2 (en) * 1980-05-30 1984-01-18 Eisai Co., Ltd. Alpha,beta-dihydropolyprenyl derivatives and a process for preparing these derivatives
EP0105404A1 (en) * 1982-09-30 1984-04-18 Merck & Co. Inc. Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation
DE3237632A1 (de) * 1982-10-11 1984-04-12 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung langkettiger linearer wachsalkohole
WO1984001899A1 (fr) * 1982-11-16 1984-05-24 Georges Motschan Nouvelle utilisation d'une vitamine unique ou d'une combinaison de diverses vitamines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE *
CHEMICAL ABSTRACTS *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY *

Also Published As

Publication number Publication date
FR2653117B1 (enExample) 1994-07-13

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