FR2577556B1 - Derives 4-substitues d'androst-4-ene-3, 17-dione utiles notamment comme inhibiteurs d'aromatase et leur fabrication - Google Patents

Derives 4-substitues d'androst-4-ene-3, 17-dione utiles notamment comme inhibiteurs d'aromatase et leur fabrication

Info

Publication number
FR2577556B1
FR2577556B1 FR8602051A FR8602051A FR2577556B1 FR 2577556 B1 FR2577556 B1 FR 2577556B1 FR 8602051 A FR8602051 A FR 8602051A FR 8602051 A FR8602051 A FR 8602051A FR 2577556 B1 FR2577556 B1 FR 2577556B1
Authority
FR
France
Prior art keywords
androst
ene
manufacture
substituted derivatives
aromatase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8602051A
Other languages
English (en)
French (fr)
Other versions
FR2577556A1 (fr
Inventor
Franco Faustini
Roberto D Alessio
Vittoria Villa
Enrico Di Salle
Paolo Lombardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2577556A1 publication Critical patent/FR2577556A1/fr
Application granted granted Critical
Publication of FR2577556B1 publication Critical patent/FR2577556B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8602051A 1985-02-15 1986-02-14 Derives 4-substitues d'androst-4-ene-3, 17-dione utiles notamment comme inhibiteurs d'aromatase et leur fabrication Expired FR2577556B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503940A GB8503940D0 (en) 1985-02-15 1985-02-15 4-substituted androstendione derivatives

Publications (2)

Publication Number Publication Date
FR2577556A1 FR2577556A1 (fr) 1986-08-22
FR2577556B1 true FR2577556B1 (fr) 1988-01-08

Family

ID=10574550

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8602051A Expired FR2577556B1 (fr) 1985-02-15 1986-02-14 Derives 4-substitues d'androst-4-ene-3, 17-dione utiles notamment comme inhibiteurs d'aromatase et leur fabrication

Country Status (28)

Country Link
US (1) US4757061A (OSRAM)
JP (1) JPS61189295A (OSRAM)
KR (1) KR930005994B1 (OSRAM)
AT (1) AT396239B (OSRAM)
AU (1) AU577667B2 (OSRAM)
BE (1) BE904226A (OSRAM)
CA (1) CA1319362C (OSRAM)
CH (1) CH669199A5 (OSRAM)
CZ (1) CZ413691A3 (OSRAM)
DE (1) DE3604179A1 (OSRAM)
DK (1) DK167221B1 (OSRAM)
ES (2) ES8706165A1 (OSRAM)
FI (1) FI84272C (OSRAM)
FR (1) FR2577556B1 (OSRAM)
GB (2) GB8503940D0 (OSRAM)
GR (1) GR860430B (OSRAM)
HK (1) HK94090A (OSRAM)
HU (1) HU194909B (OSRAM)
IE (1) IE58864B1 (OSRAM)
IT (1) IT1190335B (OSRAM)
MY (1) MY102038A (OSRAM)
NL (1) NL8600383A (OSRAM)
NZ (1) NZ215163A (OSRAM)
PT (1) PT82030B (OSRAM)
SE (2) SE468515B (OSRAM)
SG (1) SG80890G (OSRAM)
SU (1) SU1574178A3 (OSRAM)
ZA (1) ZA861118B (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3711772A1 (de) * 1987-04-08 1988-10-27 Schering Ag 4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives
US5595985A (en) 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
EP0943328B1 (en) * 1989-07-07 2004-06-16 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
US5318961A (en) * 1990-08-01 1994-06-07 Merrell Dow Pharmaceuticals Inc. 4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
AU642757B2 (en) * 1990-08-01 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors
US5218110A (en) * 1990-08-01 1993-06-08 Merrell Dow Pharmaceuticals 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
US5130424A (en) * 1990-08-01 1992-07-14 Merrell Dow Pharmaceuticals Inc. 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors
NZ239142A (en) * 1990-08-01 1994-05-26 Merrell Dow Pharma 4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5189032A (en) * 1991-03-19 1993-02-23 Merrell Dow Pharmaceuticals Inc. 4-amino-Δ4,6 -steroids and their use as 5α-reductase inhibitors
EP0582713B1 (en) * 1991-03-28 1997-06-04 Teikoku Hormone Mfg. Co., Ltd. -New D-homo-17-oxa and D-homo-17-aza-androstane derivatives
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9111260D0 (en) * 1991-05-24 1991-07-17 Erba Carlo Spa Process for the preparation of 4-amino-unsaturated androstanedione derivatives
GB9217035D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Androst-4-eno(4,5-b)pyrrole derivatives and process for their preparation
JP3293629B2 (ja) * 1992-09-30 2002-06-17 帝国臓器製薬株式会社 新規なオキサ又はアザステロイド７位置換化合物
WO1994019365A1 (en) * 1993-02-18 1994-09-01 Farmitalia Carlo Erba Srl Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB2284605A (en) * 1993-12-09 1995-06-14 Erba Carlo Spa 6-or 7-substituted 4-aminoandrostadienone derivatives
DK0758340T3 (da) * 1994-05-02 1999-08-30 Merrell Pharma Inc Fremgangsmåde til fremstilling af 4-amino-delta 4-3-ketosteroider via 4-nitro-delta 4-3-ketosteroider
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DE1203768B (de) * 1962-02-01 1965-10-28 Merck Ag E Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Testosteronreiheund Saeureadditionssalzen derselben
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
DE1668690C3 (de) * 1968-02-29 1978-09-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Androstan-Pregnan- und Cholestanreihe
US3780070A (en) * 1972-09-21 1973-12-18 Schering Corp 4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS

Also Published As

Publication number Publication date
GB8603265D0 (en) 1986-03-19
MY102038A (en) 1992-02-29
ES8708235A1 (es) 1987-10-01
PT82030A (en) 1986-03-01
IT8619361A1 (it) 1987-08-11
FI84272B (fi) 1991-07-31
AU5343386A (en) 1986-08-21
DK71486D0 (da) 1986-02-14
HUT40454A (en) 1986-12-28
JPS61189295A (ja) 1986-08-22
CZ413691A3 (en) 1994-03-16
HK94090A (en) 1990-11-23
SE8600668D0 (sv) 1986-02-14
GB8503940D0 (en) 1985-03-20
CH669199A5 (de) 1989-02-28
ES8706165A1 (es) 1987-06-01
ATA38886A (de) 1992-11-15
SG80890G (en) 1990-11-23
ZA861118B (en) 1986-10-29
HU194909B (en) 1988-03-28
DK167221B1 (da) 1993-09-20
DK71486A (da) 1986-08-16
FR2577556A1 (fr) 1986-08-22
KR930005994B1 (ko) 1993-07-01
FI860672A7 (fi) 1986-08-16
SE468515B (sv) 1993-02-01
NZ215163A (en) 1988-02-29
PT82030B (pt) 1988-07-01
US4757061A (en) 1988-07-12
BE904226A (fr) 1986-08-14
FI860672A0 (fi) 1986-02-13
IE58864B1 (en) 1993-11-17
IT1190335B (it) 1988-02-16
KR860006485A (ko) 1986-09-11
AU577667B2 (en) 1988-09-29
DE3604179A1 (de) 1986-08-21
GB2171100B (en) 1988-11-30
JPH0469638B2 (OSRAM) 1992-11-06
CA1319362C (en) 1993-06-22
ES557215A0 (es) 1987-10-01
GB2171100A (en) 1986-08-20
NL8600383A (nl) 1986-09-01
SE8600668L (sv) 1986-08-16
IE860413L (en) 1986-08-15
IT8619361A0 (it) 1986-02-11
AT396239B (de) 1993-07-26
SU1574178A3 (ru) 1990-06-23
ES552052A0 (es) 1987-06-01
GR860430B (en) 1986-06-12
FI84272C (fi) 1991-11-11

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse