FR2560196B1 - Nouvelles 8a-acylaminoergolines, leur preparation et leur utilisation comme medicaments - Google Patents

Nouvelles 8a-acylaminoergolines, leur preparation et leur utilisation comme medicaments

Info

Publication number
FR2560196B1
FR2560196B1 FR8500217A FR8500217A FR2560196B1 FR 2560196 B1 FR2560196 B1 FR 2560196B1 FR 8500217 A FR8500217 A FR 8500217A FR 8500217 A FR8500217 A FR 8500217A FR 2560196 B1 FR2560196 B1 FR 2560196B1
Authority
FR
France
Prior art keywords
acylaminoergolins
medicines
novel
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8500217A
Other languages
English (en)
French (fr)
Other versions
FR2560196A1 (fr
Inventor
Walter Haefliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2560196A1 publication Critical patent/FR2560196A1/fr
Application granted granted Critical
Publication of FR2560196B1 publication Critical patent/FR2560196B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8500217A 1984-01-12 1985-01-07 Nouvelles 8a-acylaminoergolines, leur preparation et leur utilisation comme medicaments Expired FR2560196B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (2)

Publication Number Publication Date
FR2560196A1 FR2560196A1 (fr) 1985-08-30
FR2560196B1 true FR2560196B1 (fr) 1986-07-18

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8500217A Expired FR2560196B1 (fr) 1984-01-12 1985-01-07 Nouvelles 8a-acylaminoergolines, leur preparation et leur utilisation comme medicaments

Country Status (28)

Country Link
US (2) US4950672A (OSRAM)
JP (1) JPH0655739B2 (OSRAM)
AT (1) AT391317B (OSRAM)
AU (3) AU583489B2 (OSRAM)
BE (1) BE901456A (OSRAM)
CA (1) CA1245640A (OSRAM)
CH (1) CH664568A5 (OSRAM)
CY (1) CY1542A (OSRAM)
DE (1) DE3500251C2 (OSRAM)
DK (1) DK169891B1 (OSRAM)
ES (1) ES8605514A1 (OSRAM)
FI (1) FI82466C (OSRAM)
FR (1) FR2560196B1 (OSRAM)
GB (1) GB2152507B (OSRAM)
GR (1) GR850065B (OSRAM)
HK (1) HK48590A (OSRAM)
HU (1) HU197569B (OSRAM)
IE (1) IE58228B1 (OSRAM)
IL (1) IL74043A (OSRAM)
IT (1) IT1214648B (OSRAM)
LU (1) LU85725A1 (OSRAM)
NL (1) NL193541C (OSRAM)
NZ (1) NZ210818A (OSRAM)
PH (1) PH23286A (OSRAM)
PT (1) PT79818B (OSRAM)
SE (1) SE460420B (OSRAM)
SG (1) SG32390G (OSRAM)
ZA (1) ZA85276B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
ATE107647T1 (de) * 1984-04-09 1994-07-15 Schering Ag 2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
HU195810B (en) * 1984-12-24 1988-07-28 Sandoz Ag Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
GB8500454D0 (en) 1985-02-13
GB2152507B (en) 1987-07-15
AU618290B2 (en) 1991-12-19
HUT37148A (en) 1985-11-28
AT391317B (de) 1990-09-25
CY1542A (en) 1991-03-22
SE460420B (sv) 1989-10-09
GR850065B (OSRAM) 1985-05-03
AU609539B2 (en) 1991-05-02
ZA85276B (en) 1986-08-27
IL74043A0 (en) 1985-04-30
AU3760985A (en) 1985-07-18
ES8605514A1 (es) 1986-03-16
FI850130L (fi) 1985-07-13
HK48590A (en) 1990-06-29
IE850064L (en) 1985-07-12
HU197569B (en) 1989-04-28
SE8500107D0 (sv) 1985-01-10
DK12685D0 (da) 1985-01-10
FI850130A0 (fi) 1985-01-11
JPH0655739B2 (ja) 1994-07-27
DE3500251A1 (de) 1985-07-18
FI82466C (fi) 1991-03-11
SG32390G (en) 1990-08-03
PT79818A (en) 1985-02-01
PT79818B (en) 1987-01-07
IT1214648B (it) 1990-01-18
IE58228B1 (en) 1993-08-11
DK169891B1 (da) 1995-03-27
ATA5985A (de) 1990-03-15
FR2560196A1 (fr) 1985-08-30
NL8500008A (nl) 1985-08-01
DK12685A (da) 1985-07-13
IT8547538A0 (it) 1985-01-11
FI82466B (fi) 1990-11-30
GB2152507A (en) 1985-08-07
AU583489B2 (en) 1989-05-04
CA1245640A (en) 1988-11-29
NL193541B (nl) 1999-09-01
PH23286A (en) 1989-06-30
ES539511A0 (es) 1986-03-16
US5077298A (en) 1991-12-31
DE3500251C2 (de) 1995-01-26
AU2506788A (en) 1989-03-02
JPS60174783A (ja) 1985-09-09
SE8500107L (sv) 1985-07-13
AU2506688A (en) 1989-02-23
IL74043A (en) 1988-10-31
US4950672A (en) 1990-08-21
CH664568A5 (de) 1988-03-15
LU85725A1 (fr) 1985-10-22
NZ210818A (en) 1989-02-24
NL193541C (nl) 2000-01-04
BE901456A (fr) 1985-07-08

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse