CY1542A - Novel 8a-acylaminoergolines - Google Patents

Novel 8a-acylaminoergolines Download PDF

Info

Publication number
CY1542A
CY1542A CY1542A CY154291A CY1542A CY 1542 A CY1542 A CY 1542A CY 1542 A CY1542 A CY 1542A CY 154291 A CY154291 A CY 154291A CY 1542 A CY1542 A CY 1542A
Authority
CY
Cyprus
Prior art keywords
offormula
compound
acid addition
addition salt
phenyl
Prior art date
Application number
CY1542A
Other languages
English (en)
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of CY1542A publication Critical patent/CY1542A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CY1542A 1984-01-12 1991-03-22 Novel 8a-acylaminoergolines CY1542A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (1)

Publication Number Publication Date
CY1542A true CY1542A (en) 1991-03-22

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
CY1542A CY1542A (en) 1984-01-12 1991-03-22 Novel 8a-acylaminoergolines

Country Status (28)

Country Link
US (2) US4950672A (OSRAM)
JP (1) JPH0655739B2 (OSRAM)
AT (1) AT391317B (OSRAM)
AU (3) AU583489B2 (OSRAM)
BE (1) BE901456A (OSRAM)
CA (1) CA1245640A (OSRAM)
CH (1) CH664568A5 (OSRAM)
CY (1) CY1542A (OSRAM)
DE (1) DE3500251C2 (OSRAM)
DK (1) DK169891B1 (OSRAM)
ES (1) ES8605514A1 (OSRAM)
FI (1) FI82466C (OSRAM)
FR (1) FR2560196B1 (OSRAM)
GB (1) GB2152507B (OSRAM)
GR (1) GR850065B (OSRAM)
HK (1) HK48590A (OSRAM)
HU (1) HU197569B (OSRAM)
IE (1) IE58228B1 (OSRAM)
IL (1) IL74043A (OSRAM)
IT (1) IT1214648B (OSRAM)
LU (1) LU85725A1 (OSRAM)
NL (1) NL193541C (OSRAM)
NZ (1) NZ210818A (OSRAM)
PH (1) PH23286A (OSRAM)
PT (1) PT79818B (OSRAM)
SE (1) SE460420B (OSRAM)
SG (1) SG32390G (OSRAM)
ZA (1) ZA85276B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
EP0160842B1 (de) * 1984-04-09 1994-06-22 Schering Aktiengesellschaft 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
HUT45248A (en) * 1986-01-24 1988-06-28 Sandoz Ag Process for producing 8alpha-(acylamino)-ergoline derivatives and pharmaceuticals comprising such compounds
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
MX2017009406A (es) 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo isoergolina y usos de estos.
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
MX2019014272A (es) 2017-06-01 2020-12-11 Xoc Pharmaceuticals Inc Compuestos policiclicos y usos de los mismos.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517971A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 8alpha-substituted ergoline i derivatives
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
PT79818B (en) 1987-01-07
GR850065B (OSRAM) 1985-05-03
JPH0655739B2 (ja) 1994-07-27
CH664568A5 (de) 1988-03-15
GB2152507A (en) 1985-08-07
IL74043A (en) 1988-10-31
NL193541C (nl) 2000-01-04
LU85725A1 (fr) 1985-10-22
PT79818A (en) 1985-02-01
PH23286A (en) 1989-06-30
NL8500008A (nl) 1985-08-01
FI850130A0 (fi) 1985-01-11
JPS60174783A (ja) 1985-09-09
ZA85276B (en) 1986-08-27
HK48590A (en) 1990-06-29
ES8605514A1 (es) 1986-03-16
IT1214648B (it) 1990-01-18
IL74043A0 (en) 1985-04-30
HU197569B (en) 1989-04-28
FI82466B (fi) 1990-11-30
GB8500454D0 (en) 1985-02-13
FI82466C (fi) 1991-03-11
NL193541B (nl) 1999-09-01
DK12685A (da) 1985-07-13
CA1245640A (en) 1988-11-29
FR2560196A1 (fr) 1985-08-30
SG32390G (en) 1990-08-03
US5077298A (en) 1991-12-31
DK12685D0 (da) 1985-01-10
HUT37148A (en) 1985-11-28
AT391317B (de) 1990-09-25
IT8547538A0 (it) 1985-01-11
AU618290B2 (en) 1991-12-19
ATA5985A (de) 1990-03-15
SE8500107D0 (sv) 1985-01-10
SE460420B (sv) 1989-10-09
AU2506788A (en) 1989-03-02
IE58228B1 (en) 1993-08-11
GB2152507B (en) 1987-07-15
DK169891B1 (da) 1995-03-27
ES539511A0 (es) 1986-03-16
AU2506688A (en) 1989-02-23
IE850064L (en) 1985-07-12
SE8500107L (sv) 1985-07-13
DE3500251A1 (de) 1985-07-18
BE901456A (fr) 1985-07-08
AU583489B2 (en) 1989-05-04
AU3760985A (en) 1985-07-18
AU609539B2 (en) 1991-05-02
DE3500251C2 (de) 1995-01-26
FI850130L (fi) 1985-07-13
FR2560196B1 (fr) 1986-07-18
NZ210818A (en) 1989-02-24
US4950672A (en) 1990-08-21

Similar Documents

Publication Publication Date Title
CY1542A (en) Novel 8a-acylaminoergolines
EP0126968A1 (en) Ergoline derivatives, processes for their preparation and pharmaceutical compositions containing same
AU635099B2 (en) Quinazoline derivatives and their preparation
EP0033767A1 (en) Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same
EP0009655B1 (en) 6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them
US4238490A (en) Antihypertensive pyridazin(2H)-3-ones
US4180581A (en) N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative
US4791115A (en) 2,6-dimethyl-8α-pivaloylamino-9,10-didehydro-ergoline
US4183932A (en) Fused quinazolinones and preparation thereof
US4229451A (en) Ergopeptine derivatives
PL134179B1 (en) Process for preparing 8-alpha-derivatives of ergoline from 8-beta-derivatives of ergoline by means of isomerization
IE42372B1 (en) Ergoline derivatives
US4333939A (en) Tetrahydropyridinyl-indoles
US4091099A (en) 6-Hydrocarbon-ergopeptines
US4105777A (en) Indoles
US4246201A (en) Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity
EP0882045B1 (en) Process for the preparation of granisetron
CA1122207A (en) Ergot peptide alkaloid derivatives, processes for their preparation and pharmaceutical compositions containing them
US6127362A (en) 9,10-diazatricyclo[4,4,1,12,5 ] decane and 2,7-diazatricyclo [4,4,0,03,8 ] decane derivatives having analgesic activity
US4503053A (en) C-Homo-9-oxa-ergolines
IE45702B1 (en) New pyridobenzodiazepinones, processes for their preparation and pharmaceutical compositions containing them
EP0240986B1 (en) D-nor-7-ergoline derivatives, process for preparing them, pharmaceutical composition and use
US4313944A (en) Cycloheptindoles, compositions and use
US4195086A (en) 6-Branched chain alkyl sustituted ergot alkaloids
US4146626A (en) 8-adamantylaminomethyl ergolene derivatives