FR2549061A1 - Derives du spirosuccinimide utilisables comme medicaments - Google Patents

Derives du spirosuccinimide utilisables comme medicaments Download PDF

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Publication number
FR2549061A1
FR2549061A1 FR8410017A FR8410017A FR2549061A1 FR 2549061 A1 FR2549061 A1 FR 2549061A1 FR 8410017 A FR8410017 A FR 8410017A FR 8410017 A FR8410017 A FR 8410017A FR 2549061 A1 FR2549061 A1 FR 2549061A1
Authority
FR
France
Prior art keywords
alkyl
group
formula
benzyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8410017A
Other languages
English (en)
French (fr)
Inventor
Georg Bolliger
Erhard Schenker
Rene Spiegel
Hans Weidmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solvay SA
Original Assignee
Solvay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay SA filed Critical Solvay SA
Publication of FR2549061A1 publication Critical patent/FR2549061A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR8410017A 1983-06-27 1984-06-22 Derives du spirosuccinimide utilisables comme medicaments Pending FR2549061A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH350383 1983-06-27
CH350583 1983-06-27
CH350483 1983-06-27

Publications (1)

Publication Number Publication Date
FR2549061A1 true FR2549061A1 (fr) 1985-01-18

Family

ID=27174377

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8410017A Pending FR2549061A1 (fr) 1983-06-27 1984-06-22 Derives du spirosuccinimide utilisables comme medicaments

Country Status (16)

Country Link
AU (1) AU2983384A (enExample)
DE (1) DE3422411A1 (enExample)
DK (1) DK310184A (enExample)
ES (1) ES533735A0 (enExample)
FI (1) FI842547A7 (enExample)
FR (1) FR2549061A1 (enExample)
GB (1) GB2142332A (enExample)
GR (1) GR82274B (enExample)
HU (1) HUT36793A (enExample)
IL (1) IL72218A0 (enExample)
IT (1) IT1199148B (enExample)
LU (1) LU85434A1 (enExample)
NL (1) NL8401907A (enExample)
PT (1) PT78787B (enExample)
SE (1) SE8403376L (enExample)
WO (1) WO1985000171A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431195A1 (de) * 1984-08-24 1986-03-06 Troponwerke GmbH & Co KG, 5000 Köln Neue benzodiazepine, verfahren zu ihrer herstellung sowie ihre verwendung
EP0273659A1 (en) * 1986-12-27 1988-07-06 Takeda Chemical Industries, Ltd. Azaspiro compounds, their production and use
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
BE1007765A5 (fr) 1994-06-27 1995-10-17 Blagden Ind Plc Fut metallique a ouverture totale.
DE19715758C1 (de) * 1997-04-16 1998-11-05 Man B & W Diesel Gmbh Kolben für eine Hubkolbenbrennkraftmaschine
AU2206699A (en) * 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
PT1519939E (pt) * 2002-07-05 2010-02-10 Targacept Inc Compostos n-arildiazaspirocíclicos e métodos para a sua preparação e utilização
ATE521610T1 (de) 2003-09-10 2011-09-15 Virochem Pharma Inc Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
NZ556628A (en) 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
EP3231804B1 (en) * 2008-03-21 2021-03-03 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB936477A (en) * 1959-03-25 1963-09-11 Sandoz Ltd Improvements in or relating to substituted succinimides
US3198800A (en) * 1964-05-07 1965-08-03 Sandoz Ltd 2, 8-(para-f-4-oxo-butyl)-diazaspiro[4, 5]-decane-1, 3-diones
DE1211646B (de) * 1959-03-25 1966-03-03 Sandoz Ag Verfahren zur Herstellung von Spirosuccinimiden und deren Salzen
BE897058A (fr) * 1982-06-25 1983-12-16 Sandoz Sa Utilisation d'un derive du spiro-succinimide dans le traitement de la demence du type alzheimer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB936477A (en) * 1959-03-25 1963-09-11 Sandoz Ltd Improvements in or relating to substituted succinimides
DE1211646B (de) * 1959-03-25 1966-03-03 Sandoz Ag Verfahren zur Herstellung von Spirosuccinimiden und deren Salzen
US3198800A (en) * 1964-05-07 1965-08-03 Sandoz Ltd 2, 8-(para-f-4-oxo-butyl)-diazaspiro[4, 5]-decane-1, 3-diones
BE897058A (fr) * 1982-06-25 1983-12-16 Sandoz Sa Utilisation d'un derive du spiro-succinimide dans le traitement de la demence du type alzheimer

Also Published As

Publication number Publication date
IL72218A0 (en) 1984-10-31
DK310184D0 (da) 1984-06-25
FI842547A0 (fi) 1984-06-25
DK310184A (da) 1984-12-28
GB8416172D0 (en) 1984-08-01
IT8448458A0 (it) 1984-06-26
SE8403376L (sv) 1984-12-28
LU85434A1 (fr) 1985-03-26
AU2983384A (en) 1985-01-03
IT8448458A1 (it) 1985-12-26
ES8601202A1 (es) 1985-10-16
SE8403376D0 (sv) 1984-06-25
ES533735A0 (es) 1985-10-16
GR82274B (enExample) 1984-12-13
WO1985000171A1 (fr) 1985-01-17
HUT36793A (en) 1985-10-28
PT78787A (en) 1984-07-01
DE3422411A1 (de) 1985-01-03
FI842547A7 (fi) 1984-12-28
NL8401907A (nl) 1985-01-16
GB2142332A (en) 1985-01-16
IT1199148B (it) 1988-12-30
PT78787B (en) 1986-06-05

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