FR2518992A1 - Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique Download PDF

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Publication number
FR2518992A1
FR2518992A1 FR8124244A FR8124244A FR2518992A1 FR 2518992 A1 FR2518992 A1 FR 2518992A1 FR 8124244 A FR8124244 A FR 8124244A FR 8124244 A FR8124244 A FR 8124244A FR 2518992 A1 FR2518992 A1 FR 2518992A1
Authority
FR
France
Prior art keywords
sep
formula
compounds
derivatives
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8124244A
Other languages
English (en)
French (fr)
Other versions
FR2518992B1 (enExample
Inventor
Guy Bourgery
Alain Lacour
Bernard Pourrias
Raphael Santamaria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8124244A priority Critical patent/FR2518992A1/fr
Priority to GR70145A priority patent/GR78370B/el
Priority to SE8207224A priority patent/SE453916B/sv
Priority to CA000418154A priority patent/CA1197243A/en
Priority to CH3696/85A priority patent/CH661509A5/fr
Priority to CH7473/82A priority patent/CH655313A5/fr
Priority to US06/451,537 priority patent/US4536500A/en
Priority to GB08236432A priority patent/GB2113680B/en
Priority to LU84548A priority patent/LU84548A1/fr
Priority to BE0/209800A priority patent/BE895464A/fr
Priority to IT24964/82A priority patent/IT1191152B/it
Priority to ES518518A priority patent/ES518518A0/es
Priority to DE3250049A priority patent/DE3250049C2/de
Priority to NL8204978A priority patent/NL8204978A/nl
Priority to ZA829452A priority patent/ZA829452B/xx
Priority to DE19823247860 priority patent/DE3247860A1/de
Priority to AU91934/82A priority patent/AU9193482A/en
Priority to JP57235004A priority patent/JPS58146536A/ja
Publication of FR2518992A1 publication Critical patent/FR2518992A1/fr
Application granted granted Critical
Publication of FR2518992B1 publication Critical patent/FR2518992B1/fr
Priority to GB08506732A priority patent/GB2154587B/en
Priority to US06/748,862 priority patent/US4732896A/en
Priority to SE8505219A priority patent/SE8505219D0/xx
Priority to US07/147,268 priority patent/US4831051A/en
Priority to JP3033043A priority patent/JPH04210944A/ja
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
FR8124244A 1981-12-24 1981-12-24 Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique Granted FR2518992A1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR8124244A FR2518992A1 (fr) 1981-12-24 1981-12-24 Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique
GR70145A GR78370B (enExample) 1981-12-24 1982-04-13
SE8207224A SE453916B (sv) 1981-12-24 1982-12-17 Nya aromatiska aminoalkoxiderivat, deras framstellningssett och lekemedel anvendbart som kalciumantagonist
CA000418154A CA1197243A (en) 1981-12-24 1982-12-20 Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics
CH3696/85A CH661509A5 (fr) 1981-12-24 1982-12-21 Cetones aromatiques.
CH7473/82A CH655313A5 (fr) 1981-12-24 1982-12-21 Derives aminoalkoxy aromatiques, leur procede de preparation et medicaments les renfermant.
US06/451,537 US4536500A (en) 1981-12-24 1982-12-21 Aromatic derivatives comprising an aminoalkoxy chain and pharmaceutical compositions thereof
LU84548A LU84548A1 (fr) 1981-12-24 1982-12-22 Nouveaux derives aminoalkoxy aromatiques,leur procede de preparation et leur application en therapeutique
GB08236432A GB2113680B (en) 1981-12-24 1982-12-22 New aromatic derivatives comprising an aminoalkoxy chain having an activity antagomistic to calcium
NL8204978A NL8204978A (nl) 1981-12-24 1982-12-23 Nieuwe aromatische aminoalkoxyverbindingen, werkwijze voor hun bereiding en hun toepassing in de geneeskunde.
ES518518A ES518518A0 (es) 1981-12-24 1982-12-23 Procedimiento para la fabricacion de nuevos derivados aminoalcoxi aromaticos.
DE3250049A DE3250049C2 (de) 1981-12-24 1982-12-23 Aminoalkoxyaromatische Derivate
BE0/209800A BE895464A (fr) 1981-12-24 1982-12-23 Nouveaux derives aminoalkoxy aromatiques leur procede de preparation et leur application en therapeutique
ZA829452A ZA829452B (en) 1981-12-24 1982-12-23 Aromatic derivatives, process for preparing these derivatives and pharmaceutical compositions thereof
DE19823247860 DE3247860A1 (de) 1981-12-24 1982-12-23 Aromatische aminoalkoxyderivate, verfahren zu ihrer herstellung und deren therapeutische verwendung
IT24964/82A IT1191152B (it) 1981-12-24 1982-12-23 Derivati aminoalcossi aromatici,loro procedimento di preparazione e loro applicazione in terapia
JP57235004A JPS58146536A (ja) 1981-12-24 1982-12-24 アミノアルコキシ芳香族化合物及び該化合物を有効成分とする薬剤
AU91934/82A AU9193482A (en) 1981-12-24 1982-12-24 Amino alkoxy aromatics
GB08506732A GB2154587B (en) 1981-12-24 1985-03-15 Aminoalkoxy-substituted aromatic ketones
US06/748,862 US4732896A (en) 1981-12-24 1985-06-26 Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics
SE8505219A SE8505219D0 (sv) 1981-12-24 1985-11-06 Derives aminoalkoxy aromatiques et leur procede de preparation
US07/147,268 US4831051A (en) 1981-12-24 1988-01-22 Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics
JP3033043A JPH04210944A (ja) 1981-12-24 1991-02-27 アミノアルコキシ芳香族化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8124244A FR2518992A1 (fr) 1981-12-24 1981-12-24 Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2518992A1 true FR2518992A1 (fr) 1983-07-01
FR2518992B1 FR2518992B1 (enExample) 1984-05-18

Family

ID=9265407

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8124244A Granted FR2518992A1 (fr) 1981-12-24 1981-12-24 Nouveaux derives aminoalcoxy aromatiques, leur procede de preparation et leur application en therapeutique

Country Status (4)

Country Link
JP (1) JPS58146536A (enExample)
BE (1) BE895464A (enExample)
FR (1) FR2518992A1 (enExample)
ZA (1) ZA829452B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338937A3 (en) * 1988-04-22 1990-06-27 Delalande S.A. 1-û3-(4-hydroxy-phenyl)-1-hydoxy-1-propyl¨-2-(amino-alkyleneoxy)-benzene derivatives, process for their preparation and their therapeutical use
EP0600717A1 (en) * 1992-11-30 1994-06-08 Sankyo Company Limited Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis
EP0535250A4 (en) * 1991-04-10 1994-09-28 Tsumura & Co Novel compounds and use thereof as medicine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646670A1 (fr) * 1989-05-05 1990-11-09 Delalande Sa Utilisation de derives aminoalkoxy aromatiques pour le traitement des troubles du systeme cerebrovasculaire
AUPS110302A0 (en) * 2002-03-14 2002-04-18 Biomolecular Research Institute Limited Novel chalcone derivatives and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1077722A (fr) * 1952-04-24 1954-11-10 Hoffmann La Roche Procédé pour la préparation d'amino-cétones aromatiques
FR437M (enExample) * 1960-05-25 1961-04-24
GB1022648A (en) * 1961-11-08 1966-03-16 Guidotti & C Spa Labor A process for making a series of ª‰-phenyl-propiophenone derivatives, substituted in the 2- and 4-positions and derivatives thereby obtained
FR1499864A (fr) * 1964-07-24 1967-11-03 Fisons Pharmaceuticals Ltd Procédé de préparation d'arylcétones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1077722A (fr) * 1952-04-24 1954-11-10 Hoffmann La Roche Procédé pour la préparation d'amino-cétones aromatiques
FR437M (enExample) * 1960-05-25 1961-04-24
GB1022648A (en) * 1961-11-08 1966-03-16 Guidotti & C Spa Labor A process for making a series of ª‰-phenyl-propiophenone derivatives, substituted in the 2- and 4-positions and derivatives thereby obtained
FR1499864A (fr) * 1964-07-24 1967-11-03 Fisons Pharmaceuticals Ltd Procédé de préparation d'arylcétones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/74 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338937A3 (en) * 1988-04-22 1990-06-27 Delalande S.A. 1-û3-(4-hydroxy-phenyl)-1-hydoxy-1-propyl¨-2-(amino-alkyleneoxy)-benzene derivatives, process for their preparation and their therapeutical use
EP0535250A4 (en) * 1991-04-10 1994-09-28 Tsumura & Co Novel compounds and use thereof as medicine
EP0600717A1 (en) * 1992-11-30 1994-06-08 Sankyo Company Limited Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis
US5556864A (en) * 1992-11-30 1996-09-17 Sankyo Company, Limited α-ω-diarylalkane compounds serotonin-2 receptor agonists

Also Published As

Publication number Publication date
ZA829452B (en) 1983-10-26
BE895464A (fr) 1983-06-23
JPH0438743B2 (enExample) 1992-06-25
FR2518992B1 (enExample) 1984-05-18
JPS58146536A (ja) 1983-09-01

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