FR2489331A1 - Derives de la theophylline et de la theobromine, leurs procedes de preparation et composition therapeutique les contenant - Google Patents
Derives de la theophylline et de la theobromine, leurs procedes de preparation et composition therapeutique les contenant Download PDFInfo
- Publication number
- FR2489331A1 FR2489331A1 FR8116855A FR8116855A FR2489331A1 FR 2489331 A1 FR2489331 A1 FR 2489331A1 FR 8116855 A FR8116855 A FR 8116855A FR 8116855 A FR8116855 A FR 8116855A FR 2489331 A1 FR2489331 A1 FR 2489331A1
- Authority
- FR
- France
- Prior art keywords
- group
- theophylline
- hydrogen
- denotes
- theobromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical class CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 title claims description 95
- 238000000034 method Methods 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 4
- 229960000278 theophylline Drugs 0.000 title description 83
- 239000000203 mixture Substances 0.000 title description 8
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 RADICAL METHYL Chemical class 0.000 claims abstract description 51
- 150000001875 compounds Chemical class 0.000 claims abstract description 31
- 230000000202 analgesic effect Effects 0.000 claims abstract description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 7
- 125000004076 pyridyl group Chemical group 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 4
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- 239000013074 reference sample Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229950010372 sobuzoxane Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UMFCIIBZHQXRCJ-NSCUHMNNSA-N trans-anol Chemical compound C\C=C\C1=CC=C(O)C=C1 UMFCIIBZHQXRCJ-NSCUHMNNSA-N 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12171380A JPS5746984A (en) | 1980-09-04 | 1980-09-04 | Theobromine derivative and its preparation |
| JP55121712A JPS5746983A (en) | 1980-09-04 | 1980-09-04 | Theophylline derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2489331A1 true FR2489331A1 (fr) | 1982-03-05 |
| FR2489331B1 FR2489331B1 (en, 2012) | 1984-11-30 |
Family
ID=26459005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8116855A Granted FR2489331A1 (fr) | 1980-09-04 | 1981-09-04 | Derives de la theophylline et de la theobromine, leurs procedes de preparation et composition therapeutique les contenant |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US4426383A (en, 2012) |
| CA (1) | CA1172632A (en, 2012) |
| CH (1) | CH651042A5 (en, 2012) |
| DE (1) | DE3134929A1 (en, 2012) |
| ES (1) | ES8303411A1 (en, 2012) |
| FR (1) | FR2489331A1 (en, 2012) |
| GB (1) | GB2083470B (en, 2012) |
| IT (1) | IT1138196B (en, 2012) |
| NL (1) | NL8104073A (en, 2012) |
| SE (2) | SE456910B (en, 2012) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2514003A1 (fr) * | 1981-10-06 | 1983-04-08 | Invest Tecnica Aplicada | Nouvelles xanthines a activite pharmacologique, leur procede d'obtention, les compositions pharmaceutiques qui les contiennent et leur utilisation en medecine humaine |
| FR2531085A1 (fr) * | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
| IT1203656B (it) * | 1983-06-10 | 1989-02-15 | Medosan Ind Biochimi | Attivita' antiaggregante piastrinica,antiinfiammatoria e broncolitica di esteri aroilpirrol e pirrilfenil acetici delle 7 (w-ossialchil) teofilline |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| HU198052B (en) * | 1986-02-14 | 1989-07-28 | Sandoz Ag | Process for producing purine derivatives substituted by side chain containing piperazinyl ring and pharmaceutical compositions comprising such compounds |
| US4710572A (en) * | 1986-07-30 | 1987-12-01 | American Home Products Corporation | Histamine H1 antagonists |
| US4716165A (en) * | 1986-09-24 | 1987-12-29 | American Home Products Corporation | Histamine H1 antagonists |
| US4716166A (en) * | 1986-10-21 | 1987-12-29 | American Home Products Corporation | Histamine H1 antagonists |
| JP2552494B2 (ja) * | 1987-04-08 | 1996-11-13 | ヘキストジャパン株式会社 | イミダゾチアジアジン誘導体及びその製造法 |
| FR2618151B1 (fr) * | 1987-07-16 | 1991-01-11 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique |
| US5021574A (en) * | 1988-03-03 | 1991-06-04 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
| US4876257A (en) * | 1988-03-03 | 1989-10-24 | Ortho Pharmaceutical Corporation | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents |
| US5164390A (en) * | 1988-03-03 | 1992-11-17 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
| US5332733A (en) * | 1990-11-24 | 1994-07-26 | Kali-Chemie Pharma Gmbh | Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them |
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| US6407116B1 (en) | 1997-09-16 | 2002-06-18 | Takeda Chemical Industries, Inc. | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs |
| WO1999031101A1 (en) * | 1997-12-17 | 1999-06-24 | University Of South Florida | Adenosine receptor antagonists with improved bioactivity |
| US20050209243A1 (en) * | 2002-09-27 | 2005-09-22 | Ing-Jun Chen | Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities |
| US6979687B1 (en) * | 2002-09-27 | 2005-12-27 | Ing-Jun Chen | Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities |
| EA200600071A1 (ru) * | 2003-06-20 | 2006-08-25 | Арена Фармасьютикалз, Инк. | Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором |
| US20050026848A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
| US20090285899A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
| US20090069363A1 (en) * | 2004-12-14 | 2009-03-12 | Shionogi & Co. Ltd. A Legal Entity Of Japan | Therapeutic Agent for Constipation |
| CA2686525C (en) * | 2007-03-29 | 2012-05-29 | Obschestvo S Ogranishennoi Otvetstvennostu "Farmving" | An antihistamine antiallergic agent and a method of deriving it |
| JP2010530901A (ja) * | 2007-06-22 | 2010-09-16 | ハイドラ バイオサイエンシズ インコーポレイテッド | 障害を治療するための方法および組成物 |
| WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| TWI368511B (en) * | 2009-04-30 | 2012-07-21 | Univ Kaohsiung Medical | Synthesis and pharmacokinetic activities of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives |
| TWI368513B (en) * | 2009-04-30 | 2012-07-21 | Univ Kaohsiung Medical | Synthesis of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives, and rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction thereof |
| US8470805B2 (en) * | 2009-04-30 | 2013-06-25 | Kaohsiung Medical University | Processes for preparing piperazinium salts of KMUP and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR882044A (fr) * | 1940-05-03 | 1943-05-14 | Bosch Gmbh Robert | Procédé de fabrication de graisses lubrifiantes |
| FR5086M (en, 2012) * | 1964-12-08 | 1967-05-16 | ||
| CA975367A (en) * | 1972-03-20 | 1975-09-30 | John D. Mccoll | Preparation of 7-propyl substituted theophyllines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1620576A1 (de) | 1966-11-25 | 1970-02-26 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen |
| JPS55118488A (en) * | 1979-03-05 | 1980-09-11 | Eisai Co Ltd | Theobromine derivative and its preparation |
| DE2922159A1 (de) | 1979-05-31 | 1980-12-04 | Boehringer Mannheim Gmbh | Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
| US4400381A (en) * | 1981-07-31 | 1983-08-23 | Laroche-Navarron, S.A. | Piperazine derivatives of theophylline |
-
1981
- 1981-08-31 US US06/298,227 patent/US4426383A/en not_active Expired - Fee Related
- 1981-09-02 NL NL8104073A patent/NL8104073A/nl not_active Application Discontinuation
- 1981-09-03 SE SE8105240A patent/SE456910B/sv not_active IP Right Cessation
- 1981-09-03 CH CH5675/81A patent/CH651042A5/fr not_active IP Right Cessation
- 1981-09-03 DE DE19813134929 patent/DE3134929A1/de not_active Ceased
- 1981-09-03 CA CA000385142A patent/CA1172632A/en not_active Expired
- 1981-09-03 GB GB8126653A patent/GB2083470B/en not_active Expired
- 1981-09-03 ES ES505184A patent/ES8303411A1/es not_active Expired
- 1981-09-04 FR FR8116855A patent/FR2489331A1/fr active Granted
- 1981-09-04 IT IT23790/81A patent/IT1138196B/it active
-
1983
- 1983-04-11 US US06/484,044 patent/US4564617A/en not_active Expired - Fee Related
-
1987
- 1987-11-20 SE SE8704599A patent/SE457083B/sv not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR882044A (fr) * | 1940-05-03 | 1943-05-14 | Bosch Gmbh Robert | Procédé de fabrication de graisses lubrifiantes |
| FR5086M (en, 2012) * | 1964-12-08 | 1967-05-16 | ||
| CA975367A (en) * | 1972-03-20 | 1975-09-30 | John D. Mccoll | Preparation of 7-propyl substituted theophyllines |
Non-Patent Citations (2)
| Title |
|---|
| CHEMICAL ABSTRACTS, volume 83, no. 19, 10 novembre 1975, page 549, abrégé 164130g (COLUMBUS OHIO, US) & Pol. J. Pharmacol. Pharm. 1975, 27(3), 311-16, A. ZEJC et al. "Piperazine derivatives of dimethylxanthines. III. I.piperazinoethyltheobromines" * |
| CHEMICAL ABSTRACTS, volume 84, no. 11, 15 mars 1976, page 459, abrégé 74313k (COLUMBUS OHIO, US); & CA-A-975367 (HORNER FRANK W. LTD.) 30-09-1975 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2514003A1 (fr) * | 1981-10-06 | 1983-04-08 | Invest Tecnica Aplicada | Nouvelles xanthines a activite pharmacologique, leur procede d'obtention, les compositions pharmaceutiques qui les contiennent et leur utilisation en medecine humaine |
| FR2531085A1 (fr) * | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| EP0103497A1 (fr) * | 1982-07-28 | 1984-03-21 | Adir | Nouveaux dérivés de la xanthine, leur procédé de préparation et les compositions pharmaceutiques les renfermant |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2083470A (en) | 1982-03-24 |
| ES505184A0 (es) | 1983-02-01 |
| IT8123790A0 (it) | 1981-09-04 |
| ES8303411A1 (es) | 1983-02-01 |
| CA1172632A (en) | 1984-08-14 |
| SE456910B (sv) | 1988-11-14 |
| SE8704599D0 (sv) | 1987-11-20 |
| SE457083B (sv) | 1988-11-28 |
| US4426383A (en) | 1984-01-17 |
| US4564617A (en) | 1986-01-14 |
| IT1138196B (it) | 1986-09-17 |
| NL8104073A (nl) | 1982-04-01 |
| DE3134929A1 (de) | 1982-06-09 |
| FR2489331B1 (en, 2012) | 1984-11-30 |
| SE8105240L (sv) | 1982-03-05 |
| CH651042A5 (fr) | 1985-08-30 |
| SE8704599L (sv) | 1987-11-20 |
| GB2083470B (en) | 1984-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |